iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106632

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01001531

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012243.1	ENSSHAT00000014450.1	ENSSHAP00000014331.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-102	342.7	725	1048

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 725  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 806
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+die++ ++l+f+++ e++g+t++++L+p+G+++ V ++N++e+v+ +
   Q: 807  HFPLALYKKLLKKKASLDDLKELMPDVGRSMQQLLDYPEDDIEDT-FCLNFTITVENFGTTEVKDLIPNGADTTVSKQNRQEFVDSY 892
           ********************************************8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af+eGf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 893  VDYIFNKSVASLFDAFHEGFHKVCGGKVLQLFHPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 979
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 980  LLFLTGSDRIPILGMKSLK---LVIQStGGGEAYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
           *******************...7777758889**************************************86 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKKVQDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DTDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGACACATTT TACTTCTATA TGGAAGAGAG TTTTTAAAAT CATTGAATCT GGAAGATCAA 60
AAGAAATACA AGCATGTTGT GCTGGGGAAA CGCATCCTTT GGACAGCTAG GTTTGGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

KEGG

shr:100916847

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	93.76	0.00e+00	1924.00
IUUC-Apl-003295	Anas platyrhynchos	86.96	0.00e+00	1853.00
IUUC-Aca-004336	Anolis carolinensis	86.12	0.00e+00	1830.00
IUUC-Ame-010768	Astyanax mexicanus	72.48	0.00e+00	1566.00
IUUC-Bta-013279	Bos taurus	93.09	0.00e+00	1912.00
IUUC-Bdi-014791	Brachypodium distachyon	38.28	3.00e-53	202.00
IUUC-Cel-018150	Caenorhabditis elegans	34.35	8.00e-152	531.00
IUUC-Cja-019023	Callithrix jacchus	93.76	0.00e+00	1919.00
IUUC-Cfa-021074	Canis familiaris	94.04	0.00e+00	1929.00
IUUC-Cpo-021461	Cavia porcellus	91.41	0.00e+00	1863.00
IUUC-Csa-024261	Chlorocebus sabaeus	93.85	0.00e+00	1929.00
IUUC-Cho-024513	Choloepus hoffmanni	74.75	0.00e+00	831.00
IUUC-Cin-025232	Ciona intestinalis	43.33	0.00e+00	822.00
IUUC-Dre-028829	Danio rerio	74.43	0.00e+00	1560.00
IUUC-Dno-029445	Dasypus novemcinctus	90.87	0.00e+00	1551.00
IUUC-Dor-030158	Dipodomys ordii	92.97	0.00e+00	838.00
IUUC-Dme-032103	Drosophila melanogaster	45.40	0.00e+00	904.00
IUUC-Ete-033072	Echinops telfairi	83.79	0.00e+00	1672.00
IUUC-Eca-033317	Equus caballus	91.86	0.00e+00	1878.00
IUUC-Eeu-035098	Erinaceus europaeus	48.12	0.00e+00	689.00
IUUC-Fca-035682	Felis catus	94.76	0.00e+00	1936.00
IUUC-Fal-036969	Ficedula albicollis	85.62	0.00e+00	1823.00
IUUC-Gmo-038671	Gadus morhua	72.90	0.00e+00	1556.00
IUUC-Gga-041174	Gallus gallus	86.47	0.00e+00	1849.00
IUUC-Gac-042600	Gasterosteus aculeatus	72.83	0.00e+00	1497.00
IUUC-Ggo-044589	Gorilla gorilla	93.47	0.00e+00	1946.00
IUUC-Hsa-046772	Homo sapiens	93.47	0.00e+00	1944.00
IUUC-Lch-050147	Latimeria chalumnae	80.18	0.00e+00	1434.00
IUUC-Loc-052684	Lepisosteus oculatus	79.64	0.00e+00	1682.00
IUUC-Laf-053844	Loxodonta africana	92.72	0.00e+00	1901.00
IUUC-Mcc-055531	Macaca mulatta	91.67	0.00e+00	1913.00
IUUC-Mga-060151	Meleagris gallopavo	85.76	0.00e+00	1536.00
IUUC-Mmr-060954	Microcebus murinus	93.66	0.00e+00	1921.00
IUUC-Mdo-062246	Monodelphis domestica	96.61	0.00e+00	1848.00
IUUC-Mmu-063369	Mus musculus	92.95	0.00e+00	1922.00
IUUC-Mpu-065936	Mustela putorius furo	92.97	0.00e+00	1765.00
IUUC-Mlu-067326	Myotis lucifugus	93.00	0.00e+00	1883.00
IUUC-Nle-069453	Nomascus leucogenys	94.47	0.00e+00	1933.00
IUUC-Ont-071720	Oreochromis niloticus	74.33	0.00e+00	1570.00
IUUC-Oan-073464	Ornithorhynchus anatinus	91.14	0.00e+00	1763.00
IUUC-Ocu-074207	Oryctolagus cuniculus	90.81	0.00e+00	1754.00
IUUC-Oba-075262	Oryza barthii	34.87	3.00e-47	182.00
IUUC-Ogl-077586	Oryza glaberrima	34.87	3.00e-47	182.00
IUUC-Ogu-078796	Oryza glumaepatula	34.87	3.00e-47	182.00
IUUC-Oin-079298	Oryza indica	34.87	3.00e-47	182.00
IUUC-Olo-080768	Oryza longistaminata	38.22	3.00e-53	202.00
IUUC-Ome-081908	Oryza meridionalis	34.21	7.00e-48	184.00
IUUC-Oni-082049	Oryza nivara	34.87	3.00e-47	182.00
IUUC-Opu-083608	Oryza punctata	35.07	8.00e-48	184.00
IUUC-Oru-084712	Oryza rufipogon	34.87	3.00e-47	182.00
IUUC-Osa-086078	Oryza sativa	34.87	3.00e-47	182.00
IUUC-Ola-086762	Oryzias latipes	72.99	0.00e+00	1513.00
IUUC-Oga-088435	Otolemur garnettii	93.85	0.00e+00	1924.00
IUUC-Oar-089233	Ovis aries	93.09	0.00e+00	1912.00
IUUC-Ptr-091368	Pan troglodytes	93.76	0.00e+00	1949.00
IUUC-Pan-092300	Papio anubis	93.85	0.00e+00	1929.00
IUUC-Psi-093406	Pelodiscus sinensis	88.08	0.00e+00	1867.00
IUUC-Pma-094113	Petromyzon marinus	70.08	0.00e+00	1110.00
IUUC-Ppa-095354	Physcomitrella patens	33.65	3.00e-142	499.00
IUUC-Pfo-097021	Poecilia formosa	73.31	0.00e+00	1585.00
IUUC-Pab-098327	Pongo abelii	93.85	0.00e+00	1949.00
IUUC-Pca-101075	Procavia capensis	93.01	0.00e+00	797.00
IUUC-Pva-102909	Pteropus vampyrus	82.12	0.00e+00	1608.00
IUUC-Rno-105457	Rattus norvegicus	92.72	0.00e+00	1917.00
IUUC-Sit-110415	Setaria italica	36.93	1.00e-52	200.00
IUUC-Sar-113679	Sorex araneus	85.21	0.00e+00	1103.00
IUUC-Tgu-116849	Taeniopygia guttata	81.93	0.00e+00	1721.00
IUUC-Tru-118206	Takifugu rubripes	72.56	0.00e+00	1471.00
IUUC-Tsy-119521	Tarsius syrichta	79.28	0.00e+00	1527.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.11	0.00e+00	1464.00
IUUC-Tbe-127941	Tupaia belangeri	78.70	0.00e+00	1330.00
IUUC-Ttr-128926	Tursiops truncatus	91.85	0.00e+00	1105.00
IUUC-Vpa-130448	Vicugna pacos	92.81	0.00e+00	1905.00
IUUC-Xtr-132719	Xenopus tropicalis	71.14	0.00e+00	1399.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence