iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000041104.1	ENSGALT00000072855.1	ENSGALP00000049159.1
ENSGALG00000041104.1	ENSGALT00000057031.1	ENSGALP00000057569.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-110	369.9	218	749

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 218  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPSSLSHGIKLVNPMFRGYA 301
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+                    d  +++d+                                        
   Q: 302  QQDTQEFLRCLMDQLHEELKEpivaetrdL-----------DMGDQDDKregdrspsedeflscdsssdrgegdgqsrttgsmaetell 379
           *******************87443332221...........22222222344556777789999************************* PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 380  iqdeggrgisekermkdrkfscghrrsnseqvdedadvdttmmpvdgraspemlpaprpaspcrtpepdndayvrcssrpcspvhhemh 468
           ***************************************************************************************** PP
   S: 130  .............................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.... 185
                                         ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+    
   Q: 469  sklssspprssparlgpsyvlkkaqmqasGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhsai 557
           ***************************9999999999*******************************************99888**** PP
   S: 186  .............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
                                                        +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+
   Q: 558  yqtvpaktgacgdnyasqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEI 646
           ***************************************************************************************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVte 316
           L++hLkRf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vte
   Q: 647  LCIHLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTE 731
           ********..9999*************************99888..9**************************78999*********** PP
   S: 317  vkeeevleetgstaYvlfYkr 337
           v+e+ v++   ++aYvlfY++
   Q: 732  VHETVVQN---AEAYVLFYRK 749
           ********...********98 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MMASLLRADA VPAAWHSALP AASPGAEGRP ARPAPPPACP APAAPLGPTA ASCSAGRGLP 60
SALPAAGSGP AGKHLPAVRM GDTRDICPHL DSIGEVTRDD LLLKSKGTCQ SCGAVGPNLW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGGCGT CACTGCTGCG CGCCGACGCC GTTCCCGCGG CCTGGCACTC GGCACTTCCG 60
GCGGCCTCGC CAGGAGCTGA GGGCCGCCCC GCCCGGCCCG CCCCGCCCCC GGCCTGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	83.62	0.00e+00	1510.00
IUUC-Apl-003351	Anas platyrhynchos	96.17	0.00e+00	1763.00
IUUC-Aca-005077	Anolis carolinensis	78.19	0.00e+00	1139.00
IUUC-Ame-011777	Astyanax mexicanus	76.46	0.00e+00	1355.00
IUUC-Bta-013063	Bos taurus	84.68	0.00e+00	1512.00
IUUC-Cja-019868	Callithrix jacchus	85.48	0.00e+00	1548.00
IUUC-Cfa-020761	Canis familiaris	84.37	0.00e+00	1532.00
IUUC-Cpo-022267	Cavia porcellus	80.42	0.00e+00	1436.00
IUUC-Csa-024251	Chlorocebus sabaeus	86.21	0.00e+00	1558.00
IUUC-Cho-024483	Choloepus hoffmanni	94.81	3.00e-122	432.00
IUUC-Dre-028061	Danio rerio	75.71	0.00e+00	1224.00
IUUC-Dno-029423	Dasypus novemcinctus	86.32	0.00e+00	1546.00
IUUC-Dor-030877	Dipodomys ordii	84.67	0.00e+00	1004.00
IUUC-Dme-031837	Drosophila melanogaster	49.14	2.00e-137	483.00
IUUC-Ete-032802	Echinops telfairi	74.71	2.00e-131	462.00
IUUC-Eca-034283	Equus caballus	84.39	0.00e+00	1526.00
IUUC-Eeu-034620	Erinaceus europaeus	83.48	0.00e+00	1080.00
IUUC-Fca-036357	Felis catus	85.25	0.00e+00	1513.00
IUUC-Fal-037411	Ficedula albicollis	95.28	0.00e+00	1729.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.43	0.00e+00	1328.00
IUUC-Ggo-045600	Gorilla gorilla	85.65	0.00e+00	1515.00
IUUC-Hsa-045825	Homo sapiens	86.11	0.00e+00	1528.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	73.88	0.00e+00	1277.00
IUUC-Lch-050002	Latimeria chalumnae	77.37	0.00e+00	1355.00
IUUC-Loc-052574	Lepisosteus oculatus	77.83	0.00e+00	1404.00
IUUC-Laf-054428	Loxodonta africana	85.70	0.00e+00	1530.00
IUUC-Mcc-055736	Macaca mulatta	86.00	0.00e+00	1553.00
IUUC-Mga-059781	Meleagris gallopavo	96.94	0.00e+00	1785.00
IUUC-Mdo-063048	Monodelphis domestica	88.91	0.00e+00	1546.00
IUUC-Mmu-064079	Mus musculus	83.19	0.00e+00	1506.00
IUUC-Mpu-066616	Mustela putorius furo	83.75	0.00e+00	1560.00
IUUC-Mlu-067294	Myotis lucifugus	84.79	0.00e+00	1483.00
IUUC-Nle-070015	Nomascus leucogenys	86.21	0.00e+00	1515.00
IUUC-Opr-070328	Ochotona princeps	84.81	0.00e+00	1538.00
IUUC-Ont-071464	Oreochromis niloticus	76.51	0.00e+00	1317.00
IUUC-Oan-073259	Ornithorhynchus anatinus	79.70	0.00e+00	1353.00
IUUC-Ocu-074630	Oryctolagus cuniculus	82.64	0.00e+00	1468.00
IUUC-Ola-087240	Oryzias latipes	74.95	0.00e+00	1291.00
IUUC-Oga-088761	Otolemur garnettii	84.56	0.00e+00	1538.00
IUUC-Oar-089490	Ovis aries	80.51	0.00e+00	1377.00
IUUC-Ptr-091662	Pan troglodytes	86.11	0.00e+00	1526.00
IUUC-Pan-092199	Papio anubis	85.92	0.00e+00	1548.00
IUUC-Psi-093726	Pelodiscus sinensis	92.74	0.00e+00	1694.00
IUUC-Pma-094389	Petromyzon marinus	64.38	2.00e-100	358.00
IUUC-Pab-098632	Pongo abelii	85.98	0.00e+00	1522.00
IUUC-Pca-100614	Procavia capensis	79.03	0.00e+00	1191.00
IUUC-Pva-102922	Pteropus vampyrus	82.10	0.00e+00	865.00
IUUC-Rno-105215	Rattus norvegicus	83.17	0.00e+00	1504.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.12	2.00e-25	110.00
IUUC-Sha-106601	Sarcophilus harrisii	87.15	0.00e+00	1531.00
IUUC-Ssc-115533	Sus scrofa	83.66	0.00e+00	1499.00
IUUC-Tgu-117364	Taeniopygia guttata	94.49	0.00e+00	1698.00
IUUC-Tru-117770	Takifugu rubripes	73.68	0.00e+00	1299.00
IUUC-Tni-120001	Tetraodon nigroviridis	73.25	0.00e+00	1269.00
IUUC-Ttr-128732	Tursiops truncatus	85.25	0.00e+00	1523.00
IUUC-Xtr-132157	Xenopus tropicalis	77.70	0.00e+00	1376.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence