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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045998
UUCD1 version UUC-HoS-00458
Ensembl Protein ID ENSP00000227451.3
UniProt Accession Q9Y2E6; Q0VF38; DTX4_HUMAN
Genbank Protein ID BAA76781.1; AAI19012.1; AAI22862.1
Protein Name E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4
Genbank Nucleotide ID AB023154; BC119011; BC122861
Gene Name DTX4; KIAA0937; RNF155
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000110042.7 ENST00000227451.3 ENSP00000227451.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 22388039
Classification
Family E-value Score Start End
E3 activity/RING/RING 4.00e-07 32.1 409 468
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..........kdgpl........vlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC+e++                       + +CgHv+h  Cl ++ + + ++ ++ +CP+C+
   Q: 409  CTICMERLtapsgykgpqP---TvkpdlvgkLSRCGHVYHIYCLVAM-YNNGNKDGSLQCPTCK 468
           9*******55555444320...222333333577**********555.56677**********6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
Protein Sequence
(Fasta)
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL 60
QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQHAYEKQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045998|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCGTCTTCC TGACTCTAGT ACGTTGAATC TGGCCAGAAA AACCACATTT GCTCTCTACG 60
TAGGTAATAT AAATCCATCA TTAGCGAAAT TGCTGCATCC CTTTGGACTG GGTCTCATTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045998|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50918--WWE
PS50089--ZF_RING_2
Pfam

PF02825--WWE
PF00097--zf-C3HC4
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0032479--P:regulation of type I interferon production
KEGG hsa:23220
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001420 Ailuropoda melanoleuca 92.00 0.00e+00 945.00
IUUC-Apl-003314 Anas platyrhynchos 60.43 4.00e-170 591.00
IUUC-Aca-004282 Anolis carolinensis 83.57 0.00e+00 981.00
IUUC-Aly-006456 Arabidopsis lyrata 36.92 5.00e-07 48.90
IUUC-Bta-013541 Bos taurus 95.05 8.00e-169 587.00
IUUC-Cja-019164 Callithrix jacchus 96.28 0.00e+00 1038.00
IUUC-Cfa-020475 Canis familiaris 91.37 0.00e+00 964.00
IUUC-Cpo-021358 Cavia porcellus 91.57 0.00e+00 1046.00
IUUC-Csa-023895 Chlorocebus sabaeus 98.22 0.00e+00 1124.00
IUUC-Cho-024781 Choloepus hoffmanni 98.70 9.00e-172 596.00
IUUC-Cin-025512 Ciona intestinalis 52.27 7.00e-65 241.00
IUUC-Csv-026089 Ciona savignyi 51.58 3.00e-63 236.00
IUUC-Dre-028695 Danio rerio 81.76 1.00e-163 570.00
IUUC-Dno-029115 Dasypus novemcinctus 94.67 0.00e+00 1084.00
IUUC-Dor-030701 Dipodomys ordii 87.94 0.00e+00 775.00
IUUC-Dme-031724 Drosophila melanogaster 41.63 2.00e-48 187.00
IUUC-Eca-033784 Equus caballus 97.36 0.00e+00 689.00
IUUC-Eeu-035106 Erinaceus europaeus 74.68 0.00e+00 753.00
IUUC-Fca-035528 Felis catus 93.65 0.00e+00 1058.00
IUUC-Fal-037476 Ficedula albicollis 91.79 2.00e-175 608.00
IUUC-Gmo-039590 Gadus morhua 82.54 3.00e-145 508.00
IUUC-Gga-040618 Gallus gallus 82.10 0.00e+00 936.00
IUUC-Gac-041759 Gasterosteus aculeatus 67.47 0.00e+00 787.00
IUUC-Ggo-044787 Gorilla gorilla 99.35 0.00e+00 1134.00
IUUC-Itr-048056 Ictidomys tridecemlineatus 95.58 0.00e+00 1068.00
IUUC-Lch-049663 Latimeria chalumnae 60.28 0.00e+00 680.00
IUUC-Laf-054482 Loxodonta africana 93.86 0.00e+00 1091.00
IUUC-Mcc-055090 Macaca mulatta 98.03 0.00e+00 998.00
IUUC-Meu-056882 Macropus eugenii 84.29 4.00e-169 587.00
IUUC-Mga-060182 Meleagris gallopavo 89.47 3.00e-160 558.00
IUUC-Mdo-062755 Monodelphis domestica 85.97 0.00e+00 805.00
IUUC-Mmu-063394 Mus musculus 93.86 0.00e+00 1087.00
IUUC-Mac-064552 Musa acuminata 30.65 2.00e-04 40.40
IUUC-Mpu-066276 Mustela putorius furo 94.83 0.00e+00 1080.00
IUUC-Mlu-067664 Myotis lucifugus 88.64 0.00e+00 654.00
IUUC-Nle-069360 Nomascus leucogenys 98.22 0.00e+00 1106.00
IUUC-Opr-070345 Ochotona princeps 85.60 0.00e+00 753.00
IUUC-Ont-072400 Oreochromis niloticus 62.98 0.00e+00 776.00
IUUC-Oan-073373 Ornithorhynchus anatinus 93.19 7.00e-170 589.00
IUUC-Ocu-074185 Oryctolagus cuniculus 93.37 0.00e+00 847.00
IUUC-Ola-086644 Oryzias latipes 66.40 0.00e+00 749.00
IUUC-Oga-088147 Otolemur garnettii 95.95 0.00e+00 1054.00
IUUC-Oar-090311 Ovis aries 97.03 0.00e+00 646.00
IUUC-Ptr-091535 Pan troglodytes 99.68 0.00e+00 1140.00
IUUC-Pan-092233 Papio anubis 98.22 0.00e+00 1125.00
IUUC-Psi-093689 Pelodiscus sinensis 82.59 0.00e+00 863.00
IUUC-Pma-094460 Petromyzon marinus 72.88 1.00e-133 469.00
IUUC-Pfo-096557 Poecilia formosa 66.14 0.00e+00 773.00
IUUC-Pab-098027 Pongo abelii 98.87 0.00e+00 1130.00
IUUC-Pca-100457 Procavia capensis 100.00 2.00e-125 442.00
IUUC-Pva-102381 Pteropus vampyrus 82.85 0.00e+00 712.00
IUUC-Rno-105599 Rattus norvegicus 92.98 0.00e+00 874.00
IUUC-Ssc-116338 Sus scrofa 93.55 0.00e+00 1078.00
IUUC-Tgu-116484 Taeniopygia guttata 91.53 7.00e-164 569.00
IUUC-Tru-118590 Takifugu rubripes 82.57 4.00e-156 545.00
IUUC-Tsy-119110 Tarsius syrichta 94.15 0.00e+00 798.00
IUUC-Tni-120695 Tetraodon nigroviridis 68.40 0.00e+00 784.00
IUUC-Tbe-127393 Tupaia belangeri 86.86 0.00e+00 860.00
IUUC-Ttr-128524 Tursiops truncatus 80.62 0.00e+00 726.00
IUUC-Vpa-130723 Vicugna pacos 99.07 2.00e-61 229.00
Created Date 25-Jun-2017

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