iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048392

Ensembl Protein ID

ENSSTOP00000016049.1

UniProt Accession

I3MVA4; I3MVA4_ICTTR

Genbank Protein ID

ENSSTOP00000016049

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01105139

Gene Name

USP30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000028726.1	ENSSTOT00000027625.1	ENSSTOP00000016049.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-71	241.6	42	474

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++ +++++++ +++ l+ +l +l+++l     +++++ + + ll++l+++  ++s++
   Q: 42   GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTTQYTRDQKEPPRHQYLSLTLLHLLKALScqeVTEEEVLDASCLLDVLRMYRWQISSF 130
           9*****************************7777788888889999*************888899999********************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
           e+qDa+E+++++ ++le+e    ++ +++++++ ++ e+++e          + + ++++++   ++ F+g+l+s+++c++c+++s +r
   Q: 131  EEQDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQSEitpkqitcrtRGSPHPTSSHWKAQHPFHGRLTSNMVCKHCEHQSpVR 217
           *******************9..6688888899988888888889999999999999********************************* PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 218  FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRD---VVCDNCTkieakgtlngekvehQRTTFVKQLKLGKLPQCLCIHLQRLSW 303
           ***********************************97...9******8888888888888777777*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts...................................................peekqke... 274
           s++ + + k +++v+f++ L ++ +  +                                                   p     +   
   Q: 304  SSH-GTPLKRHEHVQFNEFLMMDIYKYRllghrpsqhhpklkespgpalelqdgpaapkpvlnqpgapktqifmngacsP-----Sllp 386
           998.8888*********988888666666677877777777777666666666666666666665555555555555550.....0555 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 387  tlppplpfplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknplsTSNQWLWISDDTVRKASLQEVLS---SSAYLLFY 472
           55555555555555555559999***********************9999888888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 473  ER 474
           98 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

RYKVMKNWGV IGGIAAALAA GIYVIWGPIT ERKKRRKGLV PGLVNLGNTC FMNSLLQGLS 60
ACPAFIRWLE EFTTQYTRDQ KEPPRHQYLS LTLLHLLKAL SCQEVTEEEV LDASCLLDVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATACAAAG TTATGAAGAA CTGGGGAGTT ATAGGCGGAA TTGCTGCTGC TCTTGCAGCA 60
GGAATATATG TCATTTGGGG TCCCATTACA GAAAGAAAGA AACGTAGAAA AGGTAAGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	27.39	1.00e-15	77.80
IUUC-Aml-001733	Ailuropoda melanoleuca	93.10	0.00e+00	844.00
IUUC-Atr-002510	Amborella trichopoda	26.48	6.00e-15	75.50
IUUC-Apl-003645	Anas platyrhynchos	72.20	9.00e-102	362.00
IUUC-Aca-004583	Anolis carolinensis	69.86	5.00e-24	101.00
IUUC-Aly-005754	Arabidopsis lyrata	25.26	6.00e-24	105.00
IUUC-Ath-007622	Arabidopsis thaliana	27.13	3.00e-23	102.00
IUUC-Ame-010896	Astyanax mexicanus	62.11	1.00e-151	529.00
IUUC-Bta-012321	Bos taurus	91.84	0.00e+00	835.00
IUUC-Bdi-014795	Brachypodium distachyon	26.62	2.00e-16	79.70
IUUC-Bol-015637	Brassica oleracea	26.48	1.00e-22	100.00
IUUC-Bra-016801	Brassica rapa	26.00	9.00e-24	104.00
IUUC-Cel-018308	Caenorhabditis elegans	28.13	2.00e-36	146.00
IUUC-Cja-018826	Callithrix jacchus	94.91	0.00e+00	869.00
IUUC-Cfa-021206	Canis familiaris	92.90	0.00e+00	847.00
IUUC-Cpo-021343	Cavia porcellus	94.29	0.00e+00	846.00
IUUC-Csa-023419	Chlorocebus sabaeus	95.10	0.00e+00	871.00
IUUC-Cho-024475	Choloepus hoffmanni	89.09	2.00e-137	482.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	20.68	9.00e-12	65.10
IUUC-Cne-027061	Cryptococcus neoformans	25.73	5.00e-10	59.30
IUUC-Dre-027563	Danio rerio	58.96	2.00e-151	528.00
IUUC-Dno-029929	Dasypus novemcinctus	93.47	0.00e+00	854.00
IUUC-Dor-030166	Dipodomys ordii	84.49	0.00e+00	739.00
IUUC-Dme-031627	Drosophila melanogaster	36.23	2.00e-21	96.70
IUUC-Ete-032634	Echinops telfairi	81.43	0.00e+00	685.00
IUUC-Eca-033968	Equus caballus	93.67	0.00e+00	847.00
IUUC-Eeu-035279	Erinaceus europaeus	82.32	1.00e-58	220.00
IUUC-Fca-036525	Felis catus	94.29	0.00e+00	874.00
IUUC-Fal-036606	Ficedula albicollis	77.37	1.00e-158	552.00
IUUC-Gmo-038726	Gadus morhua	57.84	2.00e-138	485.00
IUUC-Gga-040718	Gallus gallus	77.13	1.00e-158	551.00
IUUC-Gac-042645	Gasterosteus aculeatus	57.94	7.00e-145	506.00
IUUC-Gma-042890	Glycine max	25.21	4.00e-17	82.40
IUUC-Ggo-045021	Gorilla gorilla	95.10	0.00e+00	868.00
IUUC-Hsa-045832	Homo sapiens	95.10	0.00e+00	868.00
IUUC-Lch-050662	Latimeria chalumnae	70.97	6.00e-180	623.00
IUUC-Lpe-051078	Leersia perrieri	25.85	1.00e-28	120.00
IUUC-Loc-052611	Lepisosteus oculatus	67.85	9.00e-172	596.00
IUUC-Lma-053048	Leptosphaeria maculans	19.96	3.00e-14	73.60
IUUC-Laf-053752	Loxodonta africana	93.47	0.00e+00	850.00
IUUC-Mcc-054892	Macaca mulatta	95.51	0.00e+00	874.00
IUUC-Meu-056673	Macropus eugenii	74.93	4.00e-157	546.00
IUUC-Mtr-057976	Medicago truncatula	25.73	5.00e-31	129.00
IUUC-Mla-058970	Melampsora laricipopulina	21.37	4.00e-12	66.20
IUUC-Mga-059543	Meleagris gallopavo	75.94	0.00e+00	646.00
IUUC-Mmr-061534	Microcebus murinus	94.90	0.00e+00	879.00
IUUC-Mdo-062140	Monodelphis domestica	71.37	9.00e-171	592.00
IUUC-Mmu-063673	Mus musculus	91.43	0.00e+00	830.00
IUUC-Mpu-066328	Mustela putorius furo	92.45	0.00e+00	842.00
IUUC-Mlu-067938	Myotis lucifugus	94.29	0.00e+00	867.00
IUUC-Nle-069426	Nomascus leucogenys	93.89	0.00e+00	796.00
IUUC-Opr-070796	Ochotona princeps	86.77	4.00e-121	427.00
IUUC-Ont-072248	Oreochromis niloticus	60.53	1.00e-149	522.00
IUUC-Oan-072916	Ornithorhynchus anatinus	81.22	0.00e+00	733.00
IUUC-Ocu-074459	Oryctolagus cuniculus	87.69	0.00e+00	669.00
IUUC-Oba-075765	Oryza barthii	26.07	9.00e-28	117.00
IUUC-Obr-076005	Oryza brachyantha	27.18	1.00e-29	124.00
IUUC-Ogl-077916	Oryza glaberrima	26.27	1.00e-31	130.00
IUUC-Ogu-078263	Oryza glumaepatula	26.46	1.00e-28	120.00
IUUC-Oin-080096	Oryza indica	26.33	2.00e-22	99.80
IUUC-Ome-081928	Oryza meridionalis	26.63	3.00e-30	125.00
IUUC-Oni-082424	Oryza nivara	26.32	1.00e-28	120.00
IUUC-Oru-085117	Oryza rufipogon	26.32	1.00e-28	120.00
IUUC-Ola-087429	Oryzias latipes	56.94	2.00e-139	488.00
IUUC-Oga-087981	Otolemur garnettii	94.08	0.00e+00	867.00
IUUC-Oar-089927	Ovis aries	91.63	0.00e+00	832.00
IUUC-Ptr-090878	Pan troglodytes	95.10	0.00e+00	868.00
IUUC-Pan-092698	Papio anubis	95.51	0.00e+00	874.00
IUUC-Psi-093451	Pelodiscus sinensis	76.42	0.00e+00	691.00
IUUC-Ppa-096015	Physcomitrella patens	24.12	2.00e-13	71.20
IUUC-Pfo-096096	Poecilia formosa	60.95	4.00e-149	521.00
IUUC-Pab-098676	Pongo abelii	93.67	0.00e+00	847.00
IUUC-Pca-100418	Procavia capensis	95.02	3.00e-129	454.00
IUUC-Ppe-101898	Prunus persica	25.87	3.00e-18	86.70
IUUC-Pva-103018	Pteropus vampyrus	91.84	0.00e+00	830.00
IUUC-Pgr-103423	Puccinia graminis	25.94	3.00e-09	57.40
IUUC-Pte-104330	Pyrenophora teres	21.37	8.00e-14	72.00
IUUC-Pyt-104518	Pyrenophora triticirepentis	21.23	7.00e-17	82.40
IUUC-Rno-105708	Rattus norvegicus	91.02	0.00e+00	821.00
IUUC-Sha-106971	Sarcophilus harrisii	82.35	0.00e+00	752.00
IUUC-Sit-110442	Setaria italica	26.88	2.00e-26	113.00
IUUC-Ssc-116397	Sus scrofa	91.22	0.00e+00	829.00
IUUC-Tgu-117446	Taeniopygia guttata	70.19	0.00e+00	639.00
IUUC-Tru-118268	Takifugu rubripes	59.54	3.00e-137	481.00
IUUC-Tsy-119484	Tarsius syrichta	92.13	2.00e-54	206.00
IUUC-Tni-119735	Tetraodon nigroviridis	55.58	1.00e-120	426.00
IUUC-Tca-121660	Theobroma cacao	23.92	1.00e-23	104.00
IUUC-Tae-125383	Triticum aestivum	26.75	5.00e-27	115.00
IUUC-Tur-126458	Triticum urartu	26.81	3.00e-16	79.70
IUUC-Tbe-127740	Tupaia belangeri	88.16	0.00e+00	786.00
IUUC-Ttr-129273	Tursiops truncatus	90.61	0.00e+00	816.00
IUUC-Vda-129789	Verticillium dahliae	22.41	1.00e-08	55.10
IUUC-Vvi-131177	Vitis vinifera	27.99	3.00e-20	92.80
IUUC-Xtr-132374	Xenopus tropicalis	66.46	7.00e-167	580.00
IUUC-Xma-133267	Xiphophorus maculatus	61.41	1.00e-149	522.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence