iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115509

Ensembl Protein ID

ENSSSCP00000003118.2

UniProt Accession

F1RM66; F1RM66_PIG

Genbank Protein ID

ENSSSCP00000003118

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

FP243365

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000002895.2	ENSSSCT00000003199.2	ENSSSCP00000003118.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.80e-28	98.1	1258	1311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1258 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1311
           58********************************.88888877777******876 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGSGA ERVRVALRRG GGAAGPGGAE 60
PGEDTALLRL LGLRRGLRRL RRLWAGPRVQ RGRGRGRGRG RGWGPSRGCL LEEESSDGES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCCGTAGT CCCAGCTCTC GCGGCCCTAG CTCTCCGCGG AAGGAGCGAG GTGGTCGGAC 60
TACATTTCCC TGAGACCTCT GCGCCTCACC TTCTCCCGCC GCGACGCGGG GGTCTGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	35.85	5.00e-12	66.20
IUUC-Aml-002367	Ailuropoda melanoleuca	94.16	0.00e+00	3213.00
IUUC-Atr-002455	Amborella trichopoda	48.10	4.00e-37	150.00
IUUC-Apl-003478	Anas platyrhynchos	49.88	0.00e+00	795.00
IUUC-Aca-004718	Anolis carolinensis	58.07	0.00e+00	1981.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	5.00e-37	149.00
IUUC-Ath-006690	Arabidopsis thaliana	44.16	4.00e-35	143.00
IUUC-Ame-011927	Astyanax mexicanus	43.70	0.00e+00	846.00
IUUC-Bta-013578	Bos taurus	96.25	0.00e+00	3011.00
IUUC-Bdi-014882	Brachypodium distachyon	33.33	2.00e-27	117.00
IUUC-Bol-016540	Brassica oleracea	37.39	5.00e-36	146.00
IUUC-Bra-017422	Brassica rapa	33.50	1.00e-27	118.00
IUUC-Cja-019138	Callithrix jacchus	90.01	0.00e+00	3177.00
IUUC-Cfa-020020	Canis familiaris	95.04	0.00e+00	3176.00
IUUC-Cpo-021552	Cavia porcellus	87.87	0.00e+00	3093.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.12	1.00e-37	153.00
IUUC-Csa-024216	Chlorocebus sabaeus	91.90	0.00e+00	3206.00
IUUC-Cho-024565	Choloepus hoffmanni	76.77	2.00e-163	570.00
IUUC-Cin-025724	Ciona intestinalis	54.21	5.00e-94	339.00
IUUC-Csv-026268	Ciona savignyi	39.05	8.00e-130	458.00
IUUC-Cme-027224	Cyanidioschyzon merolae	35.80	2.00e-10	61.20
IUUC-Dre-027440	Danio rerio	48.09	0.00e+00	780.00
IUUC-Dno-029583	Dasypus novemcinctus	92.08	0.00e+00	3160.00
IUUC-Dor-030903	Dipodomys ordii	87.30	0.00e+00	2159.00
IUUC-Dme-032023	Drosophila melanogaster	47.14	1.00e-92	336.00
IUUC-Ete-032834	Echinops telfairi	69.52	3.00e-125	444.00
IUUC-Eca-034026	Equus caballus	96.09	0.00e+00	1933.00
IUUC-Eeu-034687	Erinaceus europaeus	92.94	0.00e+00	1134.00
IUUC-Fca-036311	Felis catus	94.08	0.00e+00	3271.00
IUUC-Fal-037256	Ficedula albicollis	50.12	0.00e+00	809.00
IUUC-Gmo-039265	Gadus morhua	45.10	0.00e+00	811.00
IUUC-Gga-040828	Gallus gallus	49.94	0.00e+00	803.00
IUUC-Gac-042202	Gasterosteus aculeatus	50.63	0.00e+00	737.00
IUUC-Gma-043554	Glycine max	47.06	6.00e-36	145.00
IUUC-Ggo-044791	Gorilla gorilla	93.97	0.00e+00	2075.00
IUUC-Hsa-046988	Homo sapiens	91.46	0.00e+00	3109.00
IUUC-Hvu-047762	Hordeum vulgare	36.57	3.00e-20	92.80
IUUC-Itr-048907	Ictidomys tridecemlineatus	90.62	0.00e+00	3282.00
IUUC-Lch-049704	Latimeria chalumnae	50.79	0.00e+00	798.00
IUUC-Lpe-051476	Leersia perrieri	31.51	3.00e-24	107.00
IUUC-Loc-052252	Lepisosteus oculatus	53.73	0.00e+00	780.00
IUUC-Laf-053703	Loxodonta africana	93.69	0.00e+00	2156.00
IUUC-Mcc-054782	Macaca mulatta	90.35	0.00e+00	2435.00
IUUC-Meu-056046	Macropus eugenii	79.97	0.00e+00	1874.00
IUUC-Mtr-058327	Medicago truncatula	39.82	1.00e-35	145.00
IUUC-Mga-059943	Meleagris gallopavo	50.12	0.00e+00	798.00
IUUC-Mmr-061316	Microcebus murinus	91.70	0.00e+00	2809.00
IUUC-Mdo-062648	Monodelphis domestica	80.38	0.00e+00	1983.00
IUUC-Mmu-063579	Mus musculus	88.47	0.00e+00	3167.00
IUUC-Mac-064935	Musa acuminata	33.33	7.00e-30	125.00
IUUC-Mpu-066710	Mustela putorius furo	95.01	0.00e+00	3254.00
IUUC-Mlu-067559	Myotis lucifugus	90.95	0.00e+00	3209.00
IUUC-Nle-070085	Nomascus leucogenys	88.29	0.00e+00	2144.00
IUUC-Opr-071148	Ochotona princeps	87.54	0.00e+00	3112.00
IUUC-Ont-071626	Oreochromis niloticus	45.99	0.00e+00	889.00
IUUC-Oan-073324	Ornithorhynchus anatinus	48.62	0.00e+00	927.00
IUUC-Ocu-074475	Oryctolagus cuniculus	88.83	0.00e+00	3083.00
IUUC-Obr-076458	Oryza brachyantha	34.48	4.00e-28	119.00
IUUC-Ogl-077851	Oryza glaberrima	36.26	3.00e-28	119.00
IUUC-Ogu-078706	Oryza glumaepatula	36.26	2.00e-28	120.00
IUUC-Oin-079802	Oryza indica	31.43	2.00e-23	103.00
IUUC-Olo-080577	Oryza longistaminata	46.41	1.00e-33	137.00
IUUC-Osa-085421	Oryza sativa	36.26	4.00e-28	119.00
IUUC-Ola-086609	Oryzias latipes	50.13	0.00e+00	758.00
IUUC-Oga-088140	Otolemur garnettii	91.95	0.00e+00	3177.00
IUUC-Oar-089447	Ovis aries	94.83	0.00e+00	2083.00
IUUC-Ptr-090902	Pan troglodytes	91.37	0.00e+00	3120.00
IUUC-Pan-091930	Papio anubis	91.90	0.00e+00	3204.00
IUUC-Psi-094059	Pelodiscus sinensis	49.33	0.00e+00	811.00
IUUC-Pma-094258	Petromyzon marinus	49.29	9.00e-145	506.00
IUUC-Ppa-095221	Physcomitrella patens	36.02	5.00e-31	129.00
IUUC-Pfo-096884	Poecilia formosa	45.09	0.00e+00	890.00
IUUC-Pab-098404	Pongo abelii	82.32	0.00e+00	2308.00
IUUC-Pop-099585	Populus trichocarpa	33.70	1.00e-26	114.00
IUUC-Pca-100949	Procavia capensis	82.92	0.00e+00	1241.00
IUUC-Ppe-101920	Prunus persica	32.54	7.00e-28	119.00
IUUC-Pva-102634	Pteropus vampyrus	92.56	0.00e+00	3284.00
IUUC-Rno-105870	Rattus norvegicus	87.73	0.00e+00	3232.00
IUUC-Sha-107174	Sarcophilus harrisii	48.00	0.00e+00	808.00
IUUC-Smo-109164	Selaginella moellendorffii	48.70	5.00e-36	146.00
IUUC-Sit-110552	Setaria italica	34.33	6.00e-29	122.00
IUUC-Sly-111158	Solanum lycopersicum	38.14	3.00e-34	140.00
IUUC-Stu-112529	Solanum tuberosum	47.06	2.00e-36	147.00
IUUC-Sar-113289	Sorex araneus	90.79	0.00e+00	1759.00
IUUC-Tgu-117047	Taeniopygia guttata	50.86	0.00e+00	808.00
IUUC-Tru-117736	Takifugu rubripes	45.37	0.00e+00	831.00
IUUC-Tsy-118953	Tarsius syrichta	62.86	8.00e-112	400.00
IUUC-Tni-120837	Tetraodon nigroviridis	48.74	0.00e+00	729.00
IUUC-Tca-121624	Theobroma cacao	32.20	7.00e-28	119.00
IUUC-Tae-124647	Triticum aestivum	36.57	2.00e-20	93.60
IUUC-Tbe-127825	Tupaia belangeri	89.79	0.00e+00	1441.00
IUUC-Ttr-128754	Tursiops truncatus	93.41	0.00e+00	1267.00
IUUC-Vpa-130660	Vicugna pacos	47.90	0.00e+00	652.00
IUUC-Vvi-131476	Vitis vinifera	44.57	2.00e-37	150.00
IUUC-Xtr-132838	Xenopus tropicalis	49.32	0.00e+00	995.00
IUUC-Xma-133119	Xiphophorus maculatus	43.24	0.00e+00	971.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence