iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087957

Ensembl Protein ID

ENSOGAP00000003013.2

UniProt Accession

H0WMN4; H0WMN4_OTOGA

Genbank Protein ID

ENSOGAP00000003013

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAQR03029656

Gene Name

YES1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000003375.2	ENSOGAT00000003380.2	ENSOGAP00000003013.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.10e-15	54.5	87	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++++L++kkG+  ++i  ++++++W+++ + ++gk+G +P+n+v+ ++
   Q: 87   FVALYDYEARTTEDLSFKKGERFQII--NNTEGDWWEARSIATGKNGYIPSNYVAPAD 142
           789***********************..8999**********************9875 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MGCIKSKENK TPAIKYRTEN TPEPVSTSVS QYGAEPSAKG TSVNFSSLSI TPFGGSSGVT 60
PFGGASSSFS VVPSSYPAVL TGGVTIFVAL YDYEARTTED LSFKKGERFQ IINNTEGDWW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGCA TTAAAAGTAA AGAAAACAAA ACTCCAGCCA TTAAATATAG AACAGAAAAC 60
ACTCCAGAGC CTGTCAGTAC AAGTGTCAGC CAATATGGAG CAGAGCCTTC AGCAAAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0015758--P:glucose transport
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002374	Ailuropoda melanoleuca	96.13	0.00e+00	1038.00
IUUC-Apl-004032	Anas platyrhynchos	91.87	0.00e+00	1013.00
IUUC-Aca-004255	Anolis carolinensis	90.94	0.00e+00	1016.00
IUUC-Ame-010954	Astyanax mexicanus	85.19	0.00e+00	961.00
IUUC-Bta-013503	Bos taurus	95.01	0.00e+00	1006.00
IUUC-Cel-018682	Caenorhabditis elegans	58.17	9.00e-150	523.00
IUUC-Cja-019694	Callithrix jacchus	96.50	0.00e+00	1035.00
IUUC-Cfa-020402	Canis familiaris	96.12	0.00e+00	1038.00
IUUC-Cpo-022506	Cavia porcellus	95.93	0.00e+00	1039.00
IUUC-Csa-023713	Chlorocebus sabaeus	96.13	0.00e+00	1038.00
IUUC-Cin-025390	Ciona intestinalis	72.23	0.00e+00	665.00
IUUC-Csv-026029	Ciona savignyi	64.91	0.00e+00	639.00
IUUC-Dre-027978	Danio rerio	84.62	0.00e+00	927.00
IUUC-Dno-029897	Dasypus novemcinctus	96.22	0.00e+00	922.00
IUUC-Dor-030202	Dipodomys ordii	98.01	0.00e+00	933.00
IUUC-Eca-034157	Equus caballus	96.67	0.00e+00	1043.00
IUUC-Eeu-034950	Erinaceus europaeus	92.00	1.00e-176	611.00
IUUC-Fca-036233	Felis catus	95.75	0.00e+00	1059.00
IUUC-Fal-037461	Ficedula albicollis	92.05	0.00e+00	1028.00
IUUC-Gmo-038929	Gadus morhua	82.51	0.00e+00	899.00
IUUC-Gga-041107	Gallus gallus	91.50	0.00e+00	1013.00
IUUC-Gac-042321	Gasterosteus aculeatus	83.06	0.00e+00	927.00
IUUC-Hsa-047010	Homo sapiens	96.50	0.00e+00	1045.00
IUUC-Lch-050239	Latimeria chalumnae	88.35	0.00e+00	994.00
IUUC-Lpe-051166	Leersia perrieri	35.47	3.00e-23	103.00
IUUC-Loc-052314	Lepisosteus oculatus	86.79	0.00e+00	927.00
IUUC-Laf-053517	Loxodonta africana	96.12	0.00e+00	1018.00
IUUC-Mcc-055626	Macaca mulatta	96.13	0.00e+00	1038.00
IUUC-Mga-059310	Meleagris gallopavo	91.50	0.00e+00	1013.00
IUUC-Mmr-061652	Microcebus murinus	98.88	0.00e+00	1066.00
IUUC-Mdo-062963	Monodelphis domestica	90.39	0.00e+00	1006.00
IUUC-Mmu-064128	Mus musculus	94.27	0.00e+00	1039.00
IUUC-Mpu-065906	Mustela putorius furo	96.30	0.00e+00	1041.00
IUUC-Mlu-067035	Myotis lucifugus	96.51	0.00e+00	1040.00
IUUC-Nle-069041	Nomascus leucogenys	92.27	0.00e+00	985.00
IUUC-Opr-070299	Ochotona princeps	87.20	0.00e+00	916.00
IUUC-Ont-072337	Oreochromis niloticus	85.01	0.00e+00	956.00
IUUC-Oan-072997	Ornithorhynchus anatinus	97.14	0.00e+00	929.00
IUUC-Ocu-074171	Oryctolagus cuniculus	96.67	0.00e+00	1048.00
IUUC-Oba-075994	Oryza barthii	34.98	4.00e-21	96.70
IUUC-Ogl-077331	Oryza glaberrima	35.47	2.00e-23	104.00
IUUC-Opu-083538	Oryza punctata	33.99	4.00e-22	100.00
IUUC-Oru-084741	Oryza rufipogon	35.47	1.00e-23	105.00
IUUC-Ola-086619	Oryzias latipes	82.94	0.00e+00	939.00
IUUC-Oar-089670	Ovis aries	94.45	0.00e+00	1010.00
IUUC-Ptr-091352	Pan troglodytes	96.50	0.00e+00	1045.00
IUUC-Pan-092202	Papio anubis	96.13	0.00e+00	1038.00
IUUC-Psi-093310	Pelodiscus sinensis	91.68	0.00e+00	1023.00
IUUC-Pma-094232	Petromyzon marinus	87.47	0.00e+00	861.00
IUUC-Pfo-096137	Poecilia formosa	82.82	0.00e+00	929.00
IUUC-Pab-098301	Pongo abelii	98.76	0.00e+00	960.00
IUUC-Pva-102592	Pteropus vampyrus	91.68	0.00e+00	980.00
IUUC-Rno-105544	Rattus norvegicus	94.45	0.00e+00	1014.00
IUUC-Sar-113364	Sorex araneus	92.24	0.00e+00	966.00
IUUC-Tgu-117380	Taeniopygia guttata	92.05	0.00e+00	1028.00
IUUC-Tru-117594	Takifugu rubripes	83.67	0.00e+00	936.00
IUUC-Tni-120433	Tetraodon nigroviridis	83.18	0.00e+00	919.00
IUUC-Ttr-128893	Tursiops truncatus	95.75	0.00e+00	1036.00
IUUC-Vpa-130060	Vicugna pacos	96.30	0.00e+00	1034.00
IUUC-Xtr-132322	Xenopus tropicalis	89.65	0.00e+00	998.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence