iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036350

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02152341

Gene Name

VHL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000011238.2	ENSFCAT00000011240.2	ENSFCAP00000010437.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.55	5.00e-03	38.10	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	94.23	1.00e-80	296.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Felis catus

Protein Sequence
(Fasta)

MPRKAGNLEE AEAGVEEVDA EEVGPEEYGG EESGAEESGP EESDPEEPGA EEEMEAGQPR 60
PVLRSVNSCE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 120

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Nucleotide Sequence
(Fasta)

ATGCCCCGGA AGGCAGGGAA CTTGGAAGAG GCCGAGGCCG GTGTGGAGGA GGTGGACGCG 60
GAGGAGGTGG GCCCTGAAGA GTACGGCGGG GAGGAGTCGG GCGCCGAGGA GTCTGGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	88.68	3.00e-77	281.00
IUUC-Apl-003580	Anas platyrhynchos	66.28	9.00e-25	104.00
IUUC-Aca-004492	Anolis carolinensis	77.52	4.00e-55	206.00
IUUC-Ang-009806	Aspergillus niger	40.62	8.10e-02	28.10
IUUC-Ame-011818	Astyanax mexicanus	54.05	2.00e-41	161.00
IUUC-Bta-013459	Bos taurus	92.45	2.00e-82	297.00
IUUC-Cel-018173	Caenorhabditis elegans	33.33	3.00e-04	37.70
IUUC-Cja-019826	Callithrix jacchus	94.27	4.00e-82	296.00
IUUC-Cfa-021280	Canis familiaris	98.10	2.00e-87	314.00
IUUC-Cpo-022544	Cavia porcellus	94.19	9.00e-82	295.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	40.00	2.00e-08	53.10
IUUC-Csa-023644	Chlorocebus sabaeus	94.27	7.00e-83	299.00
IUUC-Cho-024479	Choloepus hoffmanni	65.91	8.00e-41	158.00
IUUC-Cin-025505	Ciona intestinalis	28.80	2.00e-05	41.20
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	4.00e-05	41.20
IUUC-Dre-028350	Danio rerio	50.00	2.00e-30	124.00
IUUC-Dno-029207	Dasypus novemcinctus	90.09	4.00e-53	200.00
IUUC-Dor-030912	Dipodomys ordii	66.45	9.00e-49	186.00
IUUC-Dme-031988	Drosophila melanogaster	26.55	3.00e-04	38.10
IUUC-Eca-034007	Equus caballus	100.00	1.00e-20	90.50
IUUC-Fal-037192	Ficedula albicollis	64.60	8.00e-53	199.00
IUUC-Gmo-038921	Gadus morhua	55.84	4.00e-43	166.00
IUUC-Gga-041016	Gallus gallus	67.36	6.00e-52	196.00
IUUC-Gac-042560	Gasterosteus aculeatus	49.35	2.00e-34	138.00
IUUC-Ggo-045419	Gorilla gorilla	94.23	8.00e-82	296.00
IUUC-Hsa-046547	Homo sapiens	94.23	9.00e-82	295.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	96.20	3.00e-85	306.00
IUUC-Lch-050463	Latimeria chalumnae	63.58	3.00e-51	194.00
IUUC-Loc-052053	Lepisosteus oculatus	55.86	9.00e-45	172.00
IUUC-Laf-053893	Loxodonta africana	94.30	1.00e-83	301.00
IUUC-Mcc-055347	Macaca mulatta	61.03	3.00e-57	213.00
IUUC-Mtr-058490	Medicago truncatula	48.48	7.00e-03	33.90
IUUC-Mdo-062169	Monodelphis domestica	74.47	5.00e-37	145.00
IUUC-Mmu-064366	Mus musculus	92.91	6.00e-73	266.00
IUUC-Mpu-066593	Mustela putorius furo	97.47	1.00e-87	315.00
IUUC-Mlu-066926	Myotis lucifugus	89.19	2.00e-85	307.00
IUUC-Nle-069724	Nomascus leucogenys	94.87	1.00e-82	298.00
IUUC-Opr-070679	Ochotona princeps	86.36	2.00e-74	270.00
IUUC-Ont-071332	Oreochromis niloticus	53.79	7.00e-40	155.00
IUUC-Ola-086869	Oryzias latipes	49.32	2.00e-36	145.00
IUUC-Oga-089124	Otolemur garnettii	96.18	6.00e-86	309.00
IUUC-Oar-089799	Ovis aries	93.14	5.00e-51	191.00
IUUC-Ptr-091186	Pan troglodytes	92.08	1.00e-48	184.00
IUUC-Pan-092150	Papio anubis	93.59	2.00e-81	294.00
IUUC-Psi-094039	Pelodiscus sinensis	65.49	8.00e-49	186.00
IUUC-Pma-094129	Petromyzon marinus	41.26	1.00e-26	112.00
IUUC-Pfo-096892	Poecilia formosa	49.66	1.00e-35	141.00
IUUC-Pab-097822	Pongo abelii	94.87	7.00e-83	299.00
IUUC-Pca-101058	Procavia capensis	85.05	9.00e-80	289.00
IUUC-Pva-102932	Pteropus vampyrus	97.45	1.00e-85	308.00
IUUC-Rno-105050	Rattus norvegicus	92.99	2.00e-83	301.00
IUUC-Sha-106738	Sarcophilus harrisii	78.57	5.00e-41	158.00
IUUC-Ssc-115973	Sus scrofa	91.82	3.00e-82	296.00
IUUC-Tgu-116663	Taeniopygia guttata	68.69	9.00e-32	127.00
IUUC-Tru-118654	Takifugu rubripes	55.17	4.00e-40	156.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.00e-02	30.00
IUUC-Ttr-128418	Tursiops truncatus	93.63	1.00e-82	298.00
IUUC-Vpa-130268	Vicugna pacos	91.84	4.00e-49	186.00
IUUC-Xtr-132506	Xenopus tropicalis	62.50	3.00e-52	197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence