iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115973

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CU655990

Gene Name

VHLL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000011567.2	ENSSSCT00000012659.2	ENSSSCP00000012326.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	27.59	2.00e-04	42.40	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	92.36	1.00e-81	300.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Sus scrofa

Protein Sequence
(Fasta)

MPRKAGKAGN AEEARAGAEE AGAESGTEES DSKELGAKEM EAGRSRPVLR SVNSREPSQV 60
IFCNRSPRVV LPVWLNFDGE PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT SDGLLVNQTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCACGCA CGCCCCGCCC CCGCCCCGCC CGGCGAGGCC CGGGTAGTCC AGGCTGTCCG 60
ACGTAATGCC CCGGAAGGCT GGGAAGGCGG GGAACGCGGA AGAGGCCCGG GCCGGCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

KEGG

ssc:100739306

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	83.03	4.00e-73	266.00
IUUC-Apl-003580	Anas platyrhynchos	65.85	3.00e-25	105.00
IUUC-Aca-004492	Anolis carolinensis	77.17	1.00e-56	211.00
IUUC-Ang-009806	Aspergillus niger	40.62	7.50e-02	27.70
IUUC-Ame-011818	Astyanax mexicanus	55.33	8.00e-45	172.00
IUUC-Bta-013459	Bos taurus	92.17	5.00e-89	319.00
IUUC-Cel-018173	Caenorhabditis elegans	31.87	8.00e-05	39.70
IUUC-Cja-019826	Callithrix jacchus	90.91	2.00e-84	304.00
IUUC-Cfa-021280	Canis familiaris	93.75	6.00e-86	309.00
IUUC-Cpo-022544	Cavia porcellus	89.88	4.00e-85	306.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	40.00	2.00e-08	53.10
IUUC-Csa-023644	Chlorocebus sabaeus	92.36	2.00e-83	301.00
IUUC-Cho-024479	Choloepus hoffmanni	61.83	2.00e-39	154.00
IUUC-Cin-025505	Ciona intestinalis	26.23	2.00e-05	41.20
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	6.00e-06	43.90
IUUC-Dre-028350	Danio rerio	53.02	1.00e-32	131.00
IUUC-Dno-029207	Dasypus novemcinctus	83.62	1.00e-52	198.00
IUUC-Dor-030912	Dipodomys ordii	67.11	3.00e-50	190.00
IUUC-Dme-031988	Drosophila melanogaster	27.59	8.00e-06	43.10
IUUC-Eca-034007	Equus caballus	97.50	2.00e-19	86.70
IUUC-Fca-036350	Felis catus	92.95	1.00e-81	295.00
IUUC-Fal-037192	Ficedula albicollis	67.74	4.00e-57	213.00
IUUC-Gmo-038921	Gadus morhua	56.33	2.00e-45	174.00
IUUC-Gga-041016	Gallus gallus	66.45	2.00e-53	201.00
IUUC-Gac-042560	Gasterosteus aculeatus	51.68	2.00e-37	148.00
IUUC-Ggo-045419	Gorilla gorilla	92.26	1.00e-81	295.00
IUUC-Hsa-046547	Homo sapiens	92.26	1.00e-81	295.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	94.97	2.00e-87	313.00
IUUC-Lch-050463	Latimeria chalumnae	62.99	1.00e-54	205.00
IUUC-Loc-052053	Lepisosteus oculatus	59.15	3.00e-48	183.00
IUUC-Laf-053893	Loxodonta africana	91.57	1.00e-87	315.00
IUUC-Mcc-055347	Macaca mulatta	74.29	1.00e-54	204.00
IUUC-Mtr-058490	Medicago truncatula	40.91	4.00e-03	34.70
IUUC-Mdo-062169	Monodelphis domestica	74.23	1.00e-38	150.00
IUUC-Mmu-064366	Mus musculus	92.81	3.00e-74	270.00
IUUC-Mpu-066593	Mustela putorius furo	91.12	2.00e-88	317.00
IUUC-Mlu-066926	Myotis lucifugus	93.21	5.00e-87	312.00
IUUC-Nle-069724	Nomascus leucogenys	92.90	2.00e-82	298.00
IUUC-Opr-070679	Ochotona princeps	77.27	1.00e-75	275.00
IUUC-Ont-071332	Oreochromis niloticus	55.03	5.00e-43	166.00
IUUC-Ola-086869	Oryzias latipes	49.36	4.00e-40	157.00
IUUC-Oga-089124	Otolemur garnettii	90.48	1.00e-85	308.00
IUUC-Oar-089799	Ovis aries	93.00	9.00e-52	194.00
IUUC-Ptr-091186	Pan troglodytes	88.00	2.00e-47	181.00
IUUC-Pan-092150	Papio anubis	92.26	1.00e-81	295.00
IUUC-Psi-094039	Pelodiscus sinensis	65.71	8.00e-51	192.00
IUUC-Pma-094129	Petromyzon marinus	43.97	3.00e-27	114.00
IUUC-Pfo-096892	Poecilia formosa	48.47	6.00e-38	149.00
IUUC-Pab-097822	Pongo abelii	92.90	1.00e-82	298.00
IUUC-Pca-101058	Procavia capensis	88.20	3.00e-77	280.00
IUUC-Pva-102932	Pteropus vampyrus	94.34	3.00e-86	310.00
IUUC-Rno-105050	Rattus norvegicus	84.27	5.00e-87	312.00
IUUC-Sha-106738	Sarcophilus harrisii	78.12	3.00e-42	162.00
IUUC-Tgu-116663	Taeniopygia guttata	69.00	1.00e-34	137.00
IUUC-Tru-118654	Takifugu rubripes	57.05	3.00e-44	170.00
IUUC-Tca-121306	Theobroma cacao	38.89	2.50e-02	30.00
IUUC-Ttr-128418	Tursiops truncatus	91.18	1.00e-89	321.00
IUUC-Vpa-130268	Vicugna pacos	89.32	9.00e-50	189.00
IUUC-Xtr-132506	Xenopus tropicalis	62.50	1.00e-54	205.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence