iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000016027.1	ENSOART00000017464.1	ENSOARP00000017222.1
ENSOARG00000016027.1	ENSOART00000017466.1	ENSOARP00000017224.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-63	215.2	163	649

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 163  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNVQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 250
           6******************************97777777777788888888*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++    +               +ee ++ k k+++++lF g++    + +  +++ + +e f +++l
   Q: 251  DSQQQDVSEFTHKLLDWLEDAFQM----K--------------AEEEMDEDKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 319
           **********************33....1..............12345677999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 320  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 397
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 398  YMHRnreitrikrdeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidasspssgsvpsqtlpsttd 486
           ****8888888888888888888888888888888888888888888888888777777777777777777777777777777765555 PP
   S: 268  ....peekqke.............................................................................. 274
               p     +                                                                              
   Q: 487  qqgaP-----Sselpstspvsiaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 570
           55550.....0555555555555566666666666666666666666666666666666667777777777777777777788888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 571  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRENrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 649
           88888888888**************************965556***************99997779************6 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MLSVFPFFQH QQTFLNQLRE ITGINDAQIL QQALKDSNGN LELAVAFLTA KNAKTPQQEE 60
TTYYQTALPG NDRYISVGSQ ADTNVIDLTG DDKDDLQRAI ALSLAESNRA FRETGITDEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTTTCGG TTTTTCCCTT CTTCCAGCAC CAGCAGACGT TTCTGAATCA ACTACGAGAA 60
ATTACAGGGA TTAATGATGC CCAGATTCTA CAGCAAGCCT TGAAGGTATG GCCTCTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	93.24	0.00e+00	2026.00
IUUC-Apl-004030	Anas platyrhynchos	83.33	0.00e+00	1879.00
IUUC-Aca-004753	Anolis carolinensis	65.26	0.00e+00	1055.00
IUUC-Afu-008871	Aspergillus fumigatus	23.72	5.00e-14	73.90
IUUC-Ani-009503	Aspergillus nidulans	33.96	2.00e-11	65.50
IUUC-Ame-010624	Astyanax mexicanus	70.94	0.00e+00	1139.00
IUUC-Bta-013166	Bos taurus	99.09	0.00e+00	1451.00
IUUC-Cel-018346	Caenorhabditis elegans	26.90	3.00e-29	124.00
IUUC-Cja-019150	Callithrix jacchus	96.22	0.00e+00	2072.00
IUUC-Cfa-020649	Canis familiaris	96.49	0.00e+00	2110.00
IUUC-Cpo-021807	Cavia porcellus	92.25	0.00e+00	2091.00
IUUC-Csa-023388	Chlorocebus sabaeus	96.31	0.00e+00	2102.00
IUUC-Cho-024343	Choloepus hoffmanni	95.65	9.00e-154	537.00
IUUC-Cin-025302	Ciona intestinalis	37.10	2.00e-95	343.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.32	1.00e-10	62.40
IUUC-Cme-027167	Cyanidioschyzon merolae	25.96	3.00e-19	90.90
IUUC-Dre-028016	Danio rerio	74.91	0.00e+00	1677.00
IUUC-Dno-029495	Dasypus novemcinctus	93.41	0.00e+00	2083.00
IUUC-Dor-030948	Dipodomys ordii	81.36	0.00e+00	1491.00
IUUC-Fca-035876	Felis catus	96.72	0.00e+00	1460.00
IUUC-Fal-036762	Ficedula albicollis	84.23	0.00e+00	1112.00
IUUC-Gmo-039490	Gadus morhua	71.39	0.00e+00	1564.00
IUUC-Gga-040817	Gallus gallus	85.06	0.00e+00	1935.00
IUUC-Gac-042473	Gasterosteus aculeatus	71.89	0.00e+00	1591.00
IUUC-Ggo-044939	Gorilla gorilla	91.81	0.00e+00	1949.00
IUUC-Hsa-046204	Homo sapiens	97.25	0.00e+00	1414.00
IUUC-Kpa-049349	Komagataella pastoris	28.27	1.00e-09	59.70
IUUC-Lch-049572	Latimeria chalumnae	79.01	0.00e+00	1762.00
IUUC-Loc-052070	Lepisosteus oculatus	77.90	0.00e+00	1720.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	5.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.23	0.00e+00	1296.00
IUUC-Mcc-055858	Macaca mulatta	96.31	0.00e+00	2105.00
IUUC-Mga-059808	Meleagris gallopavo	85.36	0.00e+00	1340.00
IUUC-Mmr-060987	Microcebus murinus	96.67	0.00e+00	2085.00
IUUC-Mmu-064245	Mus musculus	92.55	0.00e+00	1427.00
IUUC-Mpu-066304	Mustela putorius furo	95.78	0.00e+00	2100.00
IUUC-Mlu-067139	Myotis lucifugus	95.94	0.00e+00	1466.00
IUUC-Nfi-068458	Neosartorya fischeri	23.49	2.00e-16	82.00
IUUC-Nle-069075	Nomascus leucogenys	97.52	0.00e+00	1415.00
IUUC-Ont-072150	Oreochromis niloticus	73.60	0.00e+00	1680.00
IUUC-Oan-073054	Ornithorhynchus anatinus	79.78	0.00e+00	1746.00
IUUC-Ocu-074102	Oryctolagus cuniculus	93.94	0.00e+00	2088.00
IUUC-Ola-086529	Oryzias latipes	69.20	0.00e+00	1525.00
IUUC-Oga-088939	Otolemur garnettii	96.34	0.00e+00	1447.00
IUUC-Ptr-090546	Pan troglodytes	97.12	0.00e+00	1411.00
IUUC-Pan-092311	Papio anubis	96.22	0.00e+00	2104.00
IUUC-Psi-093459	Pelodiscus sinensis	90.88	0.00e+00	1173.00
IUUC-Pfo-096726	Poecilia formosa	73.05	0.00e+00	1668.00
IUUC-Pab-097608	Pongo abelii	93.51	0.00e+00	1989.00
IUUC-Pca-100718	Procavia capensis	82.35	0.00e+00	1428.00
IUUC-Pva-103150	Pteropus vampyrus	90.97	0.00e+00	1511.00
IUUC-Rno-105727	Rattus norvegicus	93.46	0.00e+00	1391.00
IUUC-Sha-107051	Sarcophilus harrisii	89.11	0.00e+00	1353.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	28.85	4.00e-09	57.40
IUUC-Sar-113097	Sorex araneus	84.94	0.00e+00	1849.00
IUUC-Ssc-115877	Sus scrofa	95.38	0.00e+00	1429.00
IUUC-Tgu-117473	Taeniopygia guttata	76.71	0.00e+00	1684.00
IUUC-Tru-118135	Takifugu rubripes	65.59	0.00e+00	1396.00
IUUC-Tsy-119471	Tarsius syrichta	88.62	0.00e+00	1838.00
IUUC-Tni-120139	Tetraodon nigroviridis	72.17	0.00e+00	1003.00
IUUC-Tbe-127549	Tupaia belangeri	87.20	0.00e+00	1863.00
IUUC-Ttr-128896	Tursiops truncatus	90.81	0.00e+00	1966.00
IUUC-Vpa-130500	Vicugna pacos	93.99	0.00e+00	1336.00
IUUC-Xtr-132896	Xenopus tropicalis	81.36	0.00e+00	1263.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence