iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069239

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01012950

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000001861.2	ENSNLET00000002464.2	ENSNLEP00000002337.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.20e-09	36.5	317	355
UBD/Alpha-Helix/CUE	2.20e-11	43.5	432	473

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 317  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 355
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 432  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 473
           5889*********************.***************95 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

LLGTIISAYR ALSQPEASPG EPDQLTASLQ PEPPVPARPS AGVPRARDVA QYLLSDSLFV 60
WVLVNTACCV LMLVAKLIQC IVFGPLRVSE RQHLKDKFWN FIFYKFIFIF GVLNVQTVEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCTGGGC ACCATCATTA GCGCCTACCG CGCGCTCAGC CAGCCCGAGG CCAGCCCCGG 60
TGAGCCGGAC CAGCTAACGG CCTCGCTGCA GCCTGAGCCG CCGGTGCCCG CCCGGCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	93.90	0.00e+00	1022.00
IUUC-Apl-003404	Anas platyrhynchos	88.08	0.00e+00	938.00
IUUC-Aca-004559	Anolis carolinensis	85.66	0.00e+00	874.00
IUUC-Ame-011640	Astyanax mexicanus	70.89	0.00e+00	800.00
IUUC-Bta-012980	Bos taurus	89.38	0.00e+00	1059.00
IUUC-Cel-018598	Caenorhabditis elegans	25.29	5.00e-35	142.00
IUUC-Cja-019577	Callithrix jacchus	97.42	0.00e+00	1170.00
IUUC-Cfa-020793	Canis familiaris	94.64	0.00e+00	1013.00
IUUC-Cpo-022387	Cavia porcellus	94.99	0.00e+00	1132.00
IUUC-Csa-023168	Chlorocebus sabaeus	99.03	0.00e+00	1189.00
IUUC-Cho-024433	Choloepus hoffmanni	97.16	0.00e+00	847.00
IUUC-Cin-025215	Ciona intestinalis	46.99	1.00e-146	513.00
IUUC-Csv-026133	Ciona savignyi	49.71	6.00e-132	464.00
IUUC-Dre-027594	Danio rerio	68.70	0.00e+00	749.00
IUUC-Dno-029407	Dasypus novemcinctus	97.13	0.00e+00	1024.00
IUUC-Dor-030961	Dipodomys ordii	96.77	0.00e+00	1043.00
IUUC-Ete-032962	Echinops telfairi	87.28	0.00e+00	867.00
IUUC-Eca-033683	Equus caballus	88.98	0.00e+00	1035.00
IUUC-Eeu-034515	Erinaceus europaeus	100.00	2.00e-80	293.00
IUUC-Fca-035398	Felis catus	95.90	0.00e+00	982.00
IUUC-Fal-036758	Ficedula albicollis	81.53	0.00e+00	882.00
IUUC-Gmo-039014	Gadus morhua	69.13	0.00e+00	735.00
IUUC-Gga-040575	Gallus gallus	88.77	0.00e+00	994.00
IUUC-Gac-041414	Gasterosteus aculeatus	67.76	0.00e+00	714.00
IUUC-Hsa-046272	Homo sapiens	99.03	0.00e+00	1152.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.91	0.00e+00	1035.00
IUUC-Lch-050491	Latimeria chalumnae	76.84	0.00e+00	843.00
IUUC-Loc-052758	Lepisosteus oculatus	75.64	0.00e+00	801.00
IUUC-Laf-053452	Loxodonta africana	96.96	0.00e+00	1035.00
IUUC-Mcc-055820	Macaca mulatta	99.45	0.00e+00	1053.00
IUUC-Meu-056726	Macropus eugenii	84.90	0.00e+00	814.00
IUUC-Mga-059937	Meleagris gallopavo	86.47	0.00e+00	955.00
IUUC-Mmr-060730	Microcebus murinus	92.73	0.00e+00	1094.00
IUUC-Mdo-062771	Monodelphis domestica	88.47	0.00e+00	1022.00
IUUC-Mmu-064219	Mus musculus	93.99	0.00e+00	1123.00
IUUC-Mpu-066796	Mustela putorius furo	95.62	0.00e+00	1018.00
IUUC-Mlu-068189	Myotis lucifugus	94.06	0.00e+00	1011.00
IUUC-Opr-070702	Ochotona princeps	90.58	3.00e-141	494.00
IUUC-Ont-072033	Oreochromis niloticus	70.79	0.00e+00	783.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.71	0.00e+00	872.00
IUUC-Ocu-074145	Oryctolagus cuniculus	92.89	0.00e+00	1106.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	68.81	0.00e+00	758.00
IUUC-Oga-088486	Otolemur garnettii	97.34	0.00e+00	1049.00
IUUC-Oar-089310	Ovis aries	95.36	0.00e+00	1042.00
IUUC-Ptr-090649	Pan troglodytes	99.46	0.00e+00	1075.00
IUUC-Pan-091692	Papio anubis	94.83	0.00e+00	1088.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	780.00
IUUC-Pma-094763	Petromyzon marinus	77.46	9.00e-98	349.00
IUUC-Ppa-095969	Physcomitrella patens	29.91	4.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	69.47	0.00e+00	763.00
IUUC-Pab-097859	Pongo abelii	99.45	0.00e+00	1056.00
IUUC-Pop-099576	Populus trichocarpa	27.06	1.00e-28	120.00
IUUC-Pca-100344	Procavia capensis	92.27	0.00e+00	1048.00
IUUC-Pva-103114	Pteropus vampyrus	67.09	0.00e+00	682.00
IUUC-Rno-105880	Rattus norvegicus	91.97	0.00e+00	1100.00
IUUC-Sha-107015	Sarcophilus harrisii	93.54	0.00e+00	989.00
IUUC-Smo-109664	Selaginella moellendorffii	31.35	2.00e-33	136.00
IUUC-Sar-113397	Sorex araneus	98.92	0.00e+00	771.00
IUUC-Ssc-115988	Sus scrofa	92.36	4.00e-143	500.00
IUUC-Tgu-116717	Taeniopygia guttata	89.56	0.00e+00	945.00
IUUC-Tru-117805	Takifugu rubripes	68.33	0.00e+00	782.00
IUUC-Tsy-119442	Tarsius syrichta	90.68	0.00e+00	947.00
IUUC-Tni-119777	Tetraodon nigroviridis	71.33	1.00e-170	592.00
IUUC-Tbe-127322	Tupaia belangeri	68.98	3.00e-116	412.00
IUUC-Ttr-128181	Tursiops truncatus	94.80	0.00e+00	1040.00
IUUC-Vpa-130483	Vicugna pacos	85.71	0.00e+00	667.00
IUUC-Xtr-132614	Xenopus tropicalis	77.56	0.00e+00	785.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence