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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063522
UUCD1 version UUC-MuM-00368
Ensembl Protein ID ENSMUSP00000114974.1
UniProt Accession Q2M2N2; A2AL52; Q3TSH4; SPOPL_MOUSE
Genbank Protein ID BAE36701.1; CAM16793.1; EDL08155.1; AAI11868.1
Protein Name Speckle-type POZ protein-like; HIB homolog 2
Genbank Nucleotide ID AK162056; AL773534; CH466542; BC111867
Gene Name Spopl
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000026771.14 ENSMUST00000132484.6 ENSMUSP00000114974.1
ENSMUSG00000026771.14 ENSMUST00000132827.7 ENSMUSP00000142047.1
ENSMUSG00000026771.14 ENSMUST00000123843.2 ENSMUSP00000142158.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RAID2
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.50e-27 95.3 200 266
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.40e-07 30.8 299 326
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D+++ v g+ef+ahk+vLaa+S+vF+a+f++e+ee + k++vei+d++pevf+++++F+Ytgk+++ 
   Q: 200  TDCCFFVRGKEFKAHKSVLAARSPVFNAMFEHEMEECT-KNRVEINDLDPEVFKEMMRFVYTGKAPNL 266
           7************************************9.*************************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfil 28
           +eN+++ l +Adl+++++Lk +a+dfi+
   Q: 299  VENVADTLVLADLHSAEQLKAQAIDFIN 326
           79*************************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP (By similarity).
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP (By similarity).
Protein Sequence
(Fasta)
MSREPTPPLP GDMSTSPVAE SWCYTQVKVV KFSYMWTINN FSFCREEMGE VLKSSTFSSG 60
PNDKMKWCLR VNPKGLDDES KDYLSLYLLL VSCPKSEVRA KFKFSLLNDK REETKAMESQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063522|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTGGCGCA CGCGCCCTGA TGACTGGCGG GGCGGAAACT GGACGCCCGA GCCTCAACAC 60
CTAGAGCGGG CTCGGGCTAG GCGCACTCTT TGGCGGCGGG TGTGTTTAAT CTTGGGGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063522|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like
PROSITE

PS50097--BTB
PS50144--MATH
Pfam

PF00651--BTB
PF00917--MATH
SMART

SM00225--BTB
SM00061--MATH
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0031397--P:negative regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG mmu:76857
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000119 Aegilops tauschii 33.23 4.00e-41 161.00
IUUC-Aml-001309 Ailuropoda melanoleuca 95.41 0.00e+00 747.00
IUUC-Atr-002922 Amborella trichopoda 29.30 7.00e-41 161.00
IUUC-Apl-003864 Anas platyrhynchos 93.37 0.00e+00 748.00
IUUC-Aca-005320 Anolis carolinensis 90.82 0.00e+00 723.00
IUUC-Ame-011843 Astyanax mexicanus 88.27 0.00e+00 716.00
IUUC-Bta-013528 Bos taurus 90.31 0.00e+00 691.00
IUUC-Bdi-014956 Brachypodium distachyon 33.76 2.00e-42 166.00
IUUC-Bol-015218 Brassica oleracea 30.26 6.00e-42 165.00
IUUC-Bra-016833 Brassica rapa 30.65 3.00e-42 166.00
IUUC-Cja-019227 Callithrix jacchus 93.11 0.00e+00 744.00
IUUC-Cfa-020990 Canis familiaris 95.66 0.00e+00 749.00
IUUC-Cpo-021660 Cavia porcellus 96.43 0.00e+00 771.00
IUUC-Csa-023569 Chlorocebus sabaeus 93.40 1.00e-156 545.00
IUUC-Cho-024732 Choloepus hoffmanni 85.71 0.00e+00 669.00
IUUC-Dre-027880 Danio rerio 89.03 0.00e+00 716.00
IUUC-Dno-029399 Dasypus novemcinctus 95.15 0.00e+00 760.00
IUUC-Dor-030177 Dipodomys ordii 85.37 0.00e+00 636.00
IUUC-Ete-032759 Echinops telfairi 89.29 0.00e+00 706.00
IUUC-Eca-033858 Equus caballus 95.92 0.00e+00 751.00
IUUC-Eeu-035156 Erinaceus europaeus 96.31 0.00e+00 631.00
IUUC-Fca-036500 Felis catus 95.66 0.00e+00 749.00
IUUC-Fal-037023 Ficedula albicollis 93.37 0.00e+00 748.00
IUUC-Gmo-038605 Gadus morhua 89.54 0.00e+00 720.00
IUUC-Gga-040204 Gallus gallus 93.37 0.00e+00 748.00
IUUC-Gac-042260 Gasterosteus aculeatus 89.80 0.00e+00 723.00
IUUC-Gma-043055 Glycine max 30.11 2.00e-42 166.00
IUUC-Ggo-045160 Gorilla gorilla 96.43 0.00e+00 771.00
IUUC-Hsa-045729 Homo sapiens 96.43 0.00e+00 772.00
IUUC-Itr-048153 Ictidomys tridecemlineatus 96.68 0.00e+00 771.00
IUUC-Lch-050036 Latimeria chalumnae 90.31 0.00e+00 699.00
IUUC-Lpe-050805 Leersia perrieri 31.04 1.00e-43 170.00
IUUC-Loc-052332 Lepisosteus oculatus 87.97 0.00e+00 706.00
IUUC-Laf-053691 Loxodonta africana 95.41 0.00e+00 764.00
IUUC-Mcc-055808 Macaca mulatta 96.17 0.00e+00 770.00
IUUC-Mtr-058012 Medicago truncatula 30.08 3.00e-42 166.00
IUUC-Mga-059990 Meleagris gallopavo 93.37 0.00e+00 748.00
IUUC-Mmr-061748 Microcebus murinus 96.68 0.00e+00 771.00
IUUC-Mdo-062472 Monodelphis domestica 88.10 0.00e+00 664.00
IUUC-Mpu-065894 Mustela putorius furo 89.69 0.00e+00 731.00
IUUC-Mlu-067879 Myotis lucifugus 95.41 0.00e+00 747.00
IUUC-Nle-069115 Nomascus leucogenys 96.43 0.00e+00 772.00
IUUC-Ont-072569 Oreochromis niloticus 89.54 0.00e+00 720.00
IUUC-Oan-073449 Ornithorhynchus anatinus 90.56 0.00e+00 726.00
IUUC-Ocu-073817 Oryctolagus cuniculus 96.94 0.00e+00 773.00
IUUC-Oba-075042 Oryza barthii 32.74 4.00e-43 169.00
IUUC-Obr-076906 Oryza brachyantha 32.87 1.00e-38 153.00
IUUC-Ogl-077426 Oryza glaberrima 32.74 2.00e-43 169.00
IUUC-Oin-079531 Oryza indica 33.33 6.00e-41 161.00
IUUC-Olo-080313 Oryza longistaminata 37.93 4.00e-40 158.00
IUUC-Oni-082862 Oryza nivara 32.94 5.00e-41 162.00
IUUC-Opu-083411 Oryza punctata 32.14 9.00e-36 144.00
IUUC-Oru-084513 Oryza rufipogon 31.86 4.00e-33 136.00
IUUC-Osa-085702 Oryza sativa 32.74 9.00e-40 157.00
IUUC-Ola-086485 Oryzias latipes 88.04 0.00e+00 709.00
IUUC-Oga-087982 Otolemur garnettii 90.82 0.00e+00 714.00
IUUC-Oar-089667 Ovis aries 94.90 0.00e+00 741.00
IUUC-Ptr-090729 Pan troglodytes 96.43 0.00e+00 772.00
IUUC-Pan-091988 Papio anubis 96.43 0.00e+00 770.00
IUUC-Psi-093103 Pelodiscus sinensis 93.62 0.00e+00 750.00
IUUC-Pfo-096279 Poecilia formosa 80.92 0.00e+00 630.00
IUUC-Pab-098431 Pongo abelii 96.43 0.00e+00 772.00
IUUC-Pop-099010 Populus trichocarpa 30.11 6.00e-33 134.00
IUUC-Pca-100373 Procavia capensis 75.08 9.00e-132 462.00
IUUC-Ppe-101816 Prunus persica 31.22 3.00e-37 149.00
IUUC-Pva-102660 Pteropus vampyrus 95.66 0.00e+00 749.00
IUUC-Pgr-103295 Puccinia graminis 22.29 2.00e-03 38.50
IUUC-Rno-105020 Rattus norvegicus 91.27 0.00e+00 739.00
IUUC-Sha-107038 Sarcophilus harrisii 92.86 0.00e+00 744.00
IUUC-Sit-110155 Setaria italica 34.04 2.00e-37 149.00
IUUC-Ssc-116199 Sus scrofa 91.07 0.00e+00 697.00
IUUC-Tgu-116755 Taeniopygia guttata 92.86 0.00e+00 739.00
IUUC-Tru-118288 Takifugu rubripes 87.24 0.00e+00 699.00
IUUC-Tni-119955 Tetraodon nigroviridis 87.06 0.00e+00 705.00
IUUC-Tre-122160 Trichoderma reesei 34.25 2.00e-09 55.80
IUUC-Tvi-122498 Trichoderma virens 31.19 1.00e-10 60.10
IUUC-Tae-123341 Triticum aestivum 33.92 1.00e-41 163.00
IUUC-Tur-126285 Triticum urartu 35.33 1.00e-41 163.00
IUUC-Ttr-129261 Tursiops truncatus 95.15 0.00e+00 744.00
IUUC-Vpa-130728 Vicugna pacos 95.58 0.00e+00 638.00
IUUC-Xtr-132576 Xenopus tropicalis 87.16 1.00e-176 612.00
Created Date 25-Jun-2017

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