iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	5.60e-33	114.3	66	260

Active Site

Position(s)	Description	Evidence
72	N/A	{ECO:0000250\|UniProtKB:Q96DC9}
75	Nucleophile	{ECO:0000250\|UniProtKB:Q96DC9}
255		{ECO:0000250\|UniProtKB:Q96DC9}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs................................................................llgvfdddslsdalve 36
           i+ t++DGnC++rA+++s                                                                l ++f+++  sd++v+
   Q: 66   IRRTRPDGNCFFRAFAYSyleylisntsayqefkklaeeskeklvqlgfpsftledfhetfmeviqrvspdnagghstvqdeLHKIFNEQGYSDYVVV 163
           899*********************************************************************************************** PP
   S: 37   aLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkkpivLlYrsgHYd 133
           +Lr+ ts  lq+e+df+++fie+  ++ +f + +vep+ k +++ihi+aL+ +L   + v++ d++e   gg++  + fpe + +++i+L+Yr+gHYd
   Q: 164  YLRLITSGKLQEEADFYQNFIEGDLTIEAFRHLEVEPMYKeSDHIHIIALCTALGAGVRVEYLDRGE---GGTVKAHDFPEGS-EPRIYLIYRPGHYD 257
           **************************************999*************************9...9************.************** PP
   S: 134  aLv 136
           +L+
   Q: 258  ILY 260
           **8 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

Protein Sequence
(Fasta)

MEPFTHNDGN RDELIIQQKR DIEKEISDTT PLVSEQLPLT CLYAEYSGDE IFTAKIQDLS 60
KKYKFIRRTR PDGNCFFRAF AYSYLEYLIS NTSAYQEFKK LAEESKEKLV QLGFPSFTLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATTTGAT GCGCCTACAC ATACATATGA TGAACAGGAA TTCTTTTTAG TTCATCAAAT 60
GAATACAAAG TAAAGTAAAT TGAAAGGAAG CGCCGATCGC AGTTGTTCAG TATTCAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0071108--P:protein K48-linked deubiquitination

KEGG

dme:Dmel_CG4968

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	56.40	2.00e-78	285.00
IUUC-Apl-003233	Anas platyrhynchos	39.71	2.00e-07	45.80
IUUC-Aca-004648	Anolis carolinensis	53.75	9.00e-73	265.00
IUUC-Aly-005710	Arabidopsis lyrata	43.20	1.00e-48	186.00
IUUC-Ath-007112	Arabidopsis thaliana	41.13	1.00e-48	185.00
IUUC-Afl-008439	Aspergillus flavus	35.63	4.00e-07	47.80
IUUC-Ame-010662	Astyanax mexicanus	56.80	1.00e-76	278.00
IUUC-Bta-013533	Bos taurus	56.40	4.00e-78	283.00
IUUC-Bol-016100	Brassica oleracea	42.13	3.00e-48	184.00
IUUC-Bra-017705	Brassica rapa	39.03	4.00e-43	167.00
IUUC-Cel-018295	Caenorhabditis elegans	35.02	1.00e-42	165.00
IUUC-Cja-019190	Callithrix jacchus	56.40	1.00e-78	285.00
IUUC-Cfa-020430	Canis familiaris	56.40	3.00e-78	283.00
IUUC-Cpo-022355	Cavia porcellus	56.40	1.00e-78	285.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.91	3.00e-44	171.00
IUUC-Csa-023286	Chlorocebus sabaeus	54.44	3.00e-76	277.00
IUUC-Cho-024411	Choloepus hoffmanni	36.30	8.00e-19	85.90
IUUC-Cin-025507	Ciona intestinalis	45.90	2.00e-41	161.00
IUUC-Csv-026273	Ciona savignyi	48.61	9.00e-66	242.00
IUUC-Dre-027843	Danio rerio	56.00	9.00e-77	278.00
IUUC-Dno-029165	Dasypus novemcinctus	58.45	9.00e-69	251.00
IUUC-Dor-030943	Dipodomys ordii	56.40	1.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	58.28	3.00e-50	191.00
IUUC-Eca-033695	Equus caballus	56.40	2.00e-78	284.00
IUUC-Eeu-034775	Erinaceus europaeus	37.39	2.00e-43	167.00
IUUC-Fca-036441	Felis catus	56.40	2.00e-78	284.00
IUUC-Gmo-038908	Gadus morhua	56.00	4.00e-75	273.00
IUUC-Ggr-040020	Gaeumannomyces graminis	29.48	2.00e-23	103.00
IUUC-Gga-040460	Gallus gallus	54.40	7.00e-74	269.00
IUUC-Gac-042417	Gasterosteus aculeatus	54.80	6.00e-75	272.00
IUUC-Gma-043712	Glycine max	41.03	1.00e-48	185.00
IUUC-Ggo-044552	Gorilla gorilla	58.90	2.00e-51	194.00
IUUC-Hsa-046766	Homo sapiens	56.40	1.00e-78	285.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	56.40	1.00e-78	285.00
IUUC-Lch-050602	Latimeria chalumnae	50.59	9.00e-68	249.00
IUUC-Loc-052003	Lepisosteus oculatus	37.23	2.00e-41	160.00
IUUC-Laf-053705	Loxodonta africana	56.40	1.00e-78	285.00
IUUC-Mcc-055745	Macaca mulatta	56.96	2.00e-75	274.00
IUUC-Meu-056569	Macropus eugenii	58.13	9.00e-68	249.00
IUUC-Mtr-057712	Medicago truncatula	40.44	5.00e-43	166.00
IUUC-Mvi-060358	Microbotryum violaceum	31.48	1.00e-14	72.40
IUUC-Mmr-061123	Microcebus murinus	52.36	9.00e-58	216.00
IUUC-Mdo-062613	Monodelphis domestica	54.80	3.00e-64	237.00
IUUC-Mmu-063658	Mus musculus	56.40	1.00e-78	285.00
IUUC-Mac-065274	Musa acuminata	33.33	5.00e-34	137.00
IUUC-Mpu-066172	Mustela putorius furo	56.40	1.00e-78	285.00
IUUC-Mlu-066966	Myotis lucifugus	56.40	2.00e-78	285.00
IUUC-Nle-069519	Nomascus leucogenys	58.90	1.00e-51	195.00
IUUC-Opr-070761	Ochotona princeps	31.36	1.00e-19	88.20
IUUC-Ont-071901	Oreochromis niloticus	54.80	1.00e-74	271.00
IUUC-Oan-072922	Ornithorhynchus anatinus	36.24	2.00e-44	171.00
IUUC-Ocu-074643	Oryctolagus cuniculus	38.26	2.00e-44	171.00
IUUC-Oni-082026	Oryza nivara	29.35	2.00e-10	59.70
IUUC-Oru-084761	Oryza rufipogon	29.35	2.00e-10	59.70
IUUC-Ola-087331	Oryzias latipes	54.31	1.00e-54	204.00
IUUC-Oga-088064	Otolemur garnettii	56.40	1.00e-78	285.00
IUUC-Oar-089251	Ovis aries	56.40	9.00e-78	282.00
IUUC-Ptr-091430	Pan troglodytes	56.40	2.00e-78	285.00
IUUC-Pan-091969	Papio anubis	37.39	1.00e-43	169.00
IUUC-Psi-093823	Pelodiscus sinensis	53.36	2.00e-71	261.00
IUUC-Pma-094366	Petromyzon marinus	56.22	4.00e-72	263.00
IUUC-Pfo-096734	Poecilia formosa	55.20	5.00e-70	256.00
IUUC-Pab-097919	Pongo abelii	52.36	2.00e-57	214.00
IUUC-Pop-099401	Populus trichocarpa	39.79	9.00e-47	179.00
IUUC-Pca-100252	Procavia capensis	48.44	3.00e-13	67.80
IUUC-Ppe-101977	Prunus persica	43.01	5.00e-52	197.00
IUUC-Pva-102499	Pteropus vampyrus	56.40	1.00e-78	285.00
IUUC-Pgr-103552	Puccinia graminis	35.29	6.40e-01	25.80
IUUC-Rno-105233	Rattus norvegicus	56.40	1.00e-78	285.00
IUUC-Sha-107081	Sarcophilus harrisii	56.40	2.00e-78	284.00
IUUC-Sly-111640	Solanum lycopersicum	40.66	2.00e-47	181.00
IUUC-Sar-113295	Sorex araneus	37.83	4.00e-43	166.00
IUUC-Ssc-116202	Sus scrofa	56.40	1.00e-78	285.00
IUUC-Tru-117664	Takifugu rubripes	52.55	5.00e-71	259.00
IUUC-Tni-120440	Tetraodon nigroviridis	34.63	1.00e-28	119.00
IUUC-Tca-121467	Theobroma cacao	41.46	9.00e-52	196.00
IUUC-Tbe-128116	Tupaia belangeri	58.90	5.00e-52	197.00
IUUC-Ttr-128622	Tursiops truncatus	56.40	3.00e-78	283.00
IUUC-Uma-129443	Ustilago maydis	30.17	1.00e-21	96.30
IUUC-Vvi-131389	Vitis vinifera	40.36	6.00e-49	186.00
IUUC-Xtr-131951	Xenopus tropicalis	37.28	5.00e-41	160.00
IUUC-Xma-134191	Xiphophorus maculatus	54.80	2.00e-69	254.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence