iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116609

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01045927

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000000099.1	ENSTGUT00000000107.1	ENSTGUP00000000107.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-57	194.1	143	627

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G+kN+gNtC++ +v+Q+L+++pe+r+l+l      +  e+++ +   +++ +++++lq lf+ ++ + +k v+p++ l+ l+++ ++ 
   Q: 143  VGMKNIGNTCWFSAVIQSLFQLPEFRRLVLGyslpqNVLESCR-SHTGKRNIAFMQELQCLFALMLGTWRKFVDPSAALELLRDVFRS- 229
           6******************************976644444444.34589999**********************************98. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           s+  qqD++Ef++ lld le++++                     +  +   k+++++++lF g++ ++ +    +n+ s+ e+f +++
   Q: 230  SEQPQQDVSEFTHKLLDWLEDAFQL------------------TVNVTSLGDKSENPMVQLFYGTFLTEGVH--KGNTFSKIETFGQYP 298
           89*********************22..................2245678999**************99987..5788899******** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e+++          ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+++ ++
   Q: 299  LQVNGYR-----NLNECLEGAMVEGEMDETP------ASQSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQTIYMD 376
           *******.....9*****9988888888633......33445566778****************************************9 PP
   S: 263  p..fcts.................................................................................. 267
           +  +c++                                                                                  
   Q: 377  RylYCNKdliqmkreemkrlkekmvtlqqklerymeygsgparfplpdmlqyvlefiatkparhscapkpslimvgdfssahcesvlrd 465
           84466668888888888777777777777777777777777777777777777777777777777777777777777777766666666 PP
   S: 268  ....................peekqke.............................................................. 274
                               p     +                                                              
   Q: 466  iqertdtrtedeaffvanssP-----Qqsssmelqppvspaelserpaphvvskeelnlvqtclqrwrneieqdvqdlkesiarinlsi 549
           666666655555555555550.....055555666666666777777777777777777777777888888888888888999999999 PP
   S: 275  ..........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                     ++ Y+L+av+vH+G+++ GHY+a+++++ +k Wl+++D +Vte+++ee ++e+      ++aY+l+Y 
   Q: 550  eqmycdpllqQVPYRLHAVLVHEGQANAGHYWAFIYDQPRKrWLKYNDISVTESSWEELERESFgglrnASAYCLMYI 627
           9999999999***************************76666******************97769************6 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

CQVLLNQMKE ITGIQDSAFL LAALKAADGD LMEAVTFLTE DPAPEPVQSP AAAELSAWEG 60
STVGKQLPQG ALNSAPHNQD NLRTANTVRP LESPKAPAAE SDAAERSDAH SAENKNRSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCAGGTGC TCTTAAATCA GATGAAAGAG ATCACAGGAA TTCAGGATTC AGCATTCCTG 60
CTTGCTGCTC TAAAGGTTTG TGTATATTGC CATTGTTTTG GGGAAAGAGA GCTCTGATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	68.39	0.00e+00	1436.00
IUUC-Apl-004010	Anas platyrhynchos	82.18	0.00e+00	1744.00
IUUC-Aca-004741	Anolis carolinensis	60.48	0.00e+00	819.00
IUUC-Ani-009503	Aspergillus nidulans	34.48	3.00e-11	63.90
IUUC-Bta-013377	Bos taurus	68.20	0.00e+00	1412.00
IUUC-Cja-019977	Callithrix jacchus	69.03	0.00e+00	1433.00
IUUC-Cpo-021817	Cavia porcellus	67.82	0.00e+00	1399.00
IUUC-Csa-023446	Chlorocebus sabaeus	66.13	0.00e+00	950.00
IUUC-Cho-024717	Choloepus hoffmanni	61.05	0.00e+00	887.00
IUUC-Csv-025911	Ciona savignyi	34.75	2.00e-144	506.00
IUUC-Dno-029559	Dasypus novemcinctus	67.09	0.00e+00	1117.00
IUUC-Dor-030955	Dipodomys ordii	65.75	0.00e+00	1358.00
IUUC-Ete-032828	Echinops telfairi	64.18	0.00e+00	890.00
IUUC-Eca-034300	Equus caballus	68.67	0.00e+00	1401.00
IUUC-Eeu-034458	Erinaceus europaeus	65.90	0.00e+00	1237.00
IUUC-Fca-035753	Felis catus	68.36	0.00e+00	1428.00
IUUC-Fal-037062	Ficedula albicollis	87.96	0.00e+00	1239.00
IUUC-Fso-038114	Fusarium solani	24.31	2.00e-13	71.20
IUUC-Gmo-039593	Gadus morhua	52.96	0.00e+00	1009.00
IUUC-Gga-040878	Gallus gallus	76.61	0.00e+00	1564.00
IUUC-Gac-041867	Gasterosteus aculeatus	53.04	0.00e+00	1053.00
IUUC-Ggo-045384	Gorilla gorilla	69.22	0.00e+00	1439.00
IUUC-Hsa-046277	Homo sapiens	69.47	0.00e+00	1445.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	64.23	0.00e+00	836.00
IUUC-Kpa-049349	Komagataella pastoris	22.68	6.00e-19	89.70
IUUC-Lch-049692	Latimeria chalumnae	61.74	0.00e+00	1278.00
IUUC-Laf-053808	Loxodonta africana	63.63	0.00e+00	1286.00
IUUC-Mcc-055473	Macaca mulatta	66.00	0.00e+00	949.00
IUUC-Meu-056416	Macropus eugenii	58.07	0.00e+00	1141.00
IUUC-Mga-060011	Meleagris gallopavo	78.52	0.00e+00	1636.00
IUUC-Mmr-060720	Microcebus murinus	66.95	0.00e+00	1364.00
IUUC-Mdo-061955	Monodelphis domestica	64.08	0.00e+00	1313.00
IUUC-Mmu-063870	Mus musculus	65.04	0.00e+00	1329.00
IUUC-Mlu-067487	Myotis lucifugus	64.91	0.00e+00	1326.00
IUUC-Nle-070044	Nomascus leucogenys	69.19	0.00e+00	1441.00
IUUC-Opr-070888	Ochotona princeps	74.37	1.00e-121	431.00
IUUC-Ocu-074523	Oryctolagus cuniculus	68.30	0.00e+00	1417.00
IUUC-Ola-086393	Oryzias latipes	53.20	0.00e+00	1064.00
IUUC-Oga-088618	Otolemur garnettii	68.15	0.00e+00	1417.00
IUUC-Ptr-091630	Pan troglodytes	71.48	0.00e+00	1164.00
IUUC-Psi-093422	Pelodiscus sinensis	66.70	0.00e+00	1432.00
IUUC-Pma-094250	Petromyzon marinus	47.35	2.00e-65	241.00
IUUC-Pab-098337	Pongo abelii	69.28	0.00e+00	1443.00
IUUC-Pca-100901	Procavia capensis	73.38	0.00e+00	818.00
IUUC-Pva-102226	Pteropus vampyrus	64.81	0.00e+00	1249.00
IUUC-Rno-105735	Rattus norvegicus	64.24	0.00e+00	912.00
IUUC-Sha-107489	Sarcophilus harrisii	69.01	0.00e+00	1439.00
IUUC-Tru-117807	Takifugu rubripes	53.63	0.00e+00	1041.00
IUUC-Tsy-118971	Tarsius syrichta	66.53	0.00e+00	940.00
IUUC-Tni-119983	Tetraodon nigroviridis	53.09	0.00e+00	1059.00
IUUC-Tme-126928	Tuber melanosporum	24.88	6.00e-19	89.70
IUUC-Ttr-128887	Tursiops truncatus	64.78	0.00e+00	1318.00
IUUC-Vpa-130614	Vicugna pacos	69.25	0.00e+00	1114.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence