iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000036986.16	ENSMUST00000085673.10	ENSMUSP00000082816.4
ENSMUSG00000036986.16	ENSMUST00000114136.8	ENSMUSP00000109771.2
ENSMUSG00000036986.16	ENSMUST00000135310.7	ENSMUSP00000122854.1
ENSMUSG00000036986.16	ENSMUST00000126690.7	ENSMUSP00000116787.1
ENSMUSG00000036986.16	ENSMUST00000124063.1	ENSMUSP00000118232.1
ENSMUSG00000036986.16	ENSMUST00000153820.7	ENSMUSP00000118955.1
ENSMUSG00000036986.16	ENSMUST00000148301.1	ENSMUSP00000120620.1
ENSMUSG00000036986.16	ENSMUST00000130459.1	ENSMUSP00000121330.1
ENSMUSG00000036986.16	ENSMUST00000124982.1	ENSMUSP00000121380.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	BioGRID
mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.049	15.3	62	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+ C+   k+ p++lpC H+ +  Cl         + +  +CP+C+
   Q: 62   CPSCQAQAKC-PKLLPCLHTLCSGCL---------EAPGLQCPICK 97
           ********99.**************9.........**********6 PP

Organism

Mus musculus

Functional Description
(View)

Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum. Regulates RB1 phosphorylation and activity. Acts as both a negative regulator of PPARGC1A acetylation and a potent activator of PPAR signaling and fatty acid oxidation. Regulates translation of HIF1A by sequestering MTOR, and thereby plays a role in neoangiogenesis and tumor vascularization. Regulates PER2 nuclear localization and circadian function. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. Required for normal development of the brain cortex during embryogenesis. Plays a role in granulopoiesis or monopoiesis of myeloid progenitor cells. May play a role regulating stem and progenitor cell fate in tissues as diverse as blood, brain and breast. Shows antiviral activity towards lymphocytic choriomeningitis virus (LCMV) and the vesicular stomatitis virus (VSV).

Protein Sequence
(Fasta)

METEPVSVQK VPAPPGSPCR QQDSALTPTP TMPPPEEPSE DYEHSQSPAE QAIQEEFQFL 60
RCPSCQAQAK CPKLLPCLHT LCSGCLEAPG LQCPICKAPG QADANGEALD NVFFESLQRR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCGGGA GGCGGGCTCT CCTCGGGCAA TCTCTCGCTC AGTTTTCTGG CTCAGATCTG 60
AGACCCATTT CCCGCCTTCA CAGACCTAAT CAAGAAATGG AAACTGAACC AGTTTCCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0051--Antiviral defense
KW-0053--Apoptosis
KW-0090--Biological rhythms
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021978--DUF3583
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12126--DUF3583
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050897--F:cobalt ion binding
GO:0003677--F:DNA binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0046332--F:SMAD binding
GO:0032183--F:SUMO binding
GO:0003713--F:transcription coactivator activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915--P:apoptotic process
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007569--P:cell aging
GO:0007050--P:cell cycle arrest
GO:0045165--P:cell fate commitment
GO:0071353--P:cellular response to interleukin-4
GO:0090398--P:cellular senescence
GO:0032922--P:circadian regulation of gene expression
GO:0007182--P:common-partner SMAD protein phosphorylation
GO:0051607--P:defense response to virus
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0010761--P:fibroblast migration
GO:0045087--P:innate immune response
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0051457--P:maintenance of protein location in nucleus
GO:0030099--P:myeloid cell differentiation
GO:0016525--P:negative regulation of angiogenesis
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:0050711--P:negative regulation of interleukin-1 secretion
GO:0045930--P:negative regulation of mitotic cell cycle
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0032938--P:negative regulation of translation in response to oxidative stress
GO:1902187--P:negative regulation of viral release from host cell
GO:0030578--P:PML body organization
GO:0060058--P:positive regulation of apoptotic process involved in mammary gland involution
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0002230--P:positive regulation of defense response to virus by host
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045345--P:positive regulation of MHC class I biosynthetic process
GO:1904816--P:positive regulation of protein localization to chromosome, telomeric region
GO:0032206--P:positive regulation of telomere maintenance
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization
GO:0006605--P:protein targeting
GO:0010522--P:regulation of calcium ion transport into cytosol
GO:0030155--P:regulation of cell adhesion
GO:0042752--P:regulation of circadian rhythm
GO:2000779--P:regulation of double-strand break repair
GO:0045343--P:regulation of MHC class I biosynthetic process
GO:0001932--P:regulation of protein phosphorylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0034097--P:response to cytokine
GO:0010332--P:response to gamma radiation
GO:0001666--P:response to hypoxia
GO:0009411--P:response to UV
GO:0048384--P:retinoic acid receptor signaling pathway
GO:0007184--P:SMAD protein import into nucleus
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway

KEGG

mmu:18854

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001901	Ailuropoda melanoleuca	67.09	0.00e+00	984.00
IUUC-Ang-009504	Aspergillus niger	26.59	5.00e-04	39.70
IUUC-Bta-012427	Bos taurus	63.70	0.00e+00	1009.00
IUUC-Cja-019029	Callithrix jacchus	68.84	0.00e+00	1045.00
IUUC-Cfa-021127	Canis familiaris	66.71	0.00e+00	984.00
IUUC-Cpo-022553	Cavia porcellus	62.48	0.00e+00	899.00
IUUC-Csa-023187	Chlorocebus sabaeus	65.40	0.00e+00	697.00
IUUC-Cho-024937	Choloepus hoffmanni	55.66	3.00e-74	273.00
IUUC-Dno-029326	Dasypus novemcinctus	65.70	0.00e+00	952.00
IUUC-Dor-030808	Dipodomys ordii	56.68	0.00e+00	643.00
IUUC-Ete-032746	Echinops telfairi	48.36	4.00e-144	505.00
IUUC-Eca-033234	Equus caballus	66.33	0.00e+00	941.00
IUUC-Fca-035648	Felis catus	67.08	0.00e+00	1031.00
IUUC-Ggo-044927	Gorilla gorilla	69.41	0.00e+00	1088.00
IUUC-Hsa-045861	Homo sapiens	69.29	0.00e+00	1087.00
IUUC-Itr-047861	Ictidomys tridecemlineatus	70.43	0.00e+00	1123.00
IUUC-Loc-052276	Lepisosteus oculatus	33.62	1.00e-49	191.00
IUUC-Laf-054059	Loxodonta africana	65.29	0.00e+00	994.00
IUUC-Meu-056495	Macropus eugenii	51.59	9.00e-94	338.00
IUUC-Mga-059224	Meleagris gallopavo	40.83	8.00e-36	145.00
IUUC-Mmr-061507	Microcebus murinus	64.97	0.00e+00	983.00
IUUC-Mdo-062196	Monodelphis domestica	43.76	6.00e-170	592.00
IUUC-Mpu-066024	Mustela putorius furo	62.53	0.00e+00	925.00
IUUC-Mlu-066980	Myotis lucifugus	64.72	0.00e+00	953.00
IUUC-Nle-069779	Nomascus leucogenys	68.27	0.00e+00	1036.00
IUUC-Ocu-074016	Oryctolagus cuniculus	59.21	0.00e+00	879.00
IUUC-Oga-089085	Otolemur garnettii	58.41	0.00e+00	876.00
IUUC-Oar-089980	Ovis aries	62.89	0.00e+00	973.00
IUUC-Ptr-091681	Pan troglodytes	69.13	0.00e+00	1081.00
IUUC-Pan-091965	Papio anubis	67.87	0.00e+00	1017.00
IUUC-Psi-093577	Pelodiscus sinensis	35.56	2.00e-102	367.00
IUUC-Pab-098215	Pongo abelii	61.51	4.00e-151	528.00
IUUC-Pca-100883	Procavia capensis	59.65	0.00e+00	695.00
IUUC-Pva-102465	Pteropus vampyrus	61.18	0.00e+00	657.00
IUUC-Rno-105120	Rattus norvegicus	82.17	0.00e+00	1416.00
IUUC-Ssl-108501	Sclerotinia sclerotiorum	28.26	3.00e-02	34.30
IUUC-Sar-113320	Sorex araneus	61.25	5.00e-83	302.00
IUUC-Ssc-116042	Sus scrofa	63.86	0.00e+00	988.00
IUUC-Tbe-127880	Tupaia belangeri	63.59	4.00e-117	415.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence