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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063323
UUCD1 version UUC-MuM-00331
Ensembl Protein ID ENSMUSP00000101241.3
UniProt Accession P62874; P04697; P04901; GBB1_MOUSE
Genbank Protein ID AAC52905.1; BAB63904.1; AAH13058.1
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Transducin beta chain 1
Genbank Nucleotide ID U29055; AB042854; BC013058
Gene Name Gnb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029064.15 ENSMUST00000105616.9 ENSMUSP00000101241.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.50e-42 142.1 224 260
UBD/Beta-Prp 9.00e-55 187.1 136 340
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++++++++f ++ + +++GsdD t++++Dlr +  
   Q: 224  GHESDINAICFfPNgNAFATGSDDATCRLFDLRADQE 260
           8*********99777*****************98865 PP
   

   UBD/Beta-Prp
   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetl 133
            r+l gh++  ++++f +d   +vt+s D t  +wd++tg+++ t++gh+ +v+sls+ p++  +vsG  d  +++wd+++g c + t+
   Q: 136  SRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ-TF 222
           5899***************7.7****************************************************************.** PP
   S: 134  sghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlngh 221
           +gh++ +n +++ p+gn +++Gs+D t+rl+dl+ ++ l t    +    ++s+sf+++g+ l++g +d   ++wd  + +    l gh
   Q: 223  TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYsHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGH 311
           ************************************999999434455789************************************** PP
   S: 222  tdnvksvrfspnderlvsgssDgsiriWd 250
           ++ v+++ +++++  +++gs D  ++iW+
   Q: 312  DNRVSCLGVTDDGMAVATGSWDSFLKIWN 340
           ****************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
 Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).
Protein Sequence
(Fasta)
MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA 60
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063323|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGGGGCCG CCGCGCCCAT CCTGATGGCT GGAGGCGTCT GAGGGGCGGA CGGCGACGGC 60
GGCGGCGGCG GCGGCGGTGG CGGGCGCGGG CGGCGAGGGC AGCGGGGCTG GGACTGGAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063323|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0044297--C:cell body
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:1903561--C:extracellular vesicle
GO:0005834--C:heterotrimeric G-protein complex
GO:0005765--C:lysosomal membrane
GO:0043209--C:myelin sheath
GO:0001917--C:photoreceptor inner segment
GO:0001750--C:photoreceptor outer segment
GO:0042622--C:photoreceptor outer segment membrane
GO:0005886--C:plasma membrane
GO:0047391--F:alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0003924--F:GTPase activity
GO:0051020--F:GTPase binding
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0030507--F:spectrin binding
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007603--P:phototransduction, visible light
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070208--P:protein heterotrimerization
GO:0060041--P:retina development in camera-type eye
GO:0050909--P:sensory perception of taste
KEGG mmu:14688
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001337 Ailuropoda melanoleuca 100.00 0.00e+00 670.00
IUUC-Apl-003811 Anas platyrhynchos 97.94 0.00e+00 657.00
IUUC-Acl-008154 Aspergillus clavatus 68.55 5.00e-138 484.00
IUUC-Afl-008568 Aspergillus flavus 68.82 6.00e-140 490.00
IUUC-Afu-008789 Aspergillus fumigatus 68.55 5.00e-138 484.00
IUUC-Ani-009213 Aspergillus nidulans 69.12 3.00e-139 488.00
IUUC-Ang-009836 Aspergillus niger 68.82 5.00e-140 490.00
IUUC-Aor-010165 Aspergillus oryzae 68.82 6.00e-140 490.00
IUUC-Ame-011092 Astyanax mexicanus 98.24 0.00e+00 694.00
IUUC-Bta-012709 Bos taurus 100.00 0.00e+00 670.00
IUUC-Cja-019782 Callithrix jacchus 100.00 0.00e+00 670.00
IUUC-Cfa-020111 Canis familiaris 100.00 0.00e+00 670.00
IUUC-Cpo-022494 Cavia porcellus 100.00 0.00e+00 670.00
IUUC-Csa-023672 Chlorocebus sabaeus 100.00 0.00e+00 670.00
IUUC-Cne-026811 Cryptococcus neoformans 67.57 3.00e-138 484.00
IUUC-Dre-028478 Danio rerio 98.82 0.00e+00 696.00
IUUC-Eca-033359 Equus caballus 99.71 0.00e+00 669.00
IUUC-Fal-037004 Ficedula albicollis 97.94 0.00e+00 657.00
IUUC-Gmo-039709 Gadus morhua 98.53 0.00e+00 694.00
IUUC-Gga-041163 Gallus gallus 97.55 0.00e+00 629.00
IUUC-Gac-041386 Gasterosteus aculeatus 97.94 0.00e+00 669.00
IUUC-Ggo-045261 Gorilla gorilla 99.69 0.00e+00 630.00
IUUC-Hsa-046450 Homo sapiens 100.00 0.00e+00 670.00
IUUC-Itr-049064 Ictidomys tridecemlineatus 100.00 0.00e+00 670.00
IUUC-Lch-049422 Latimeria chalumnae 97.65 0.00e+00 657.00
IUUC-Loc-052939 Lepisosteus oculatus 97.94 0.00e+00 671.00
IUUC-Lma-052985 Leptosphaeria maculans 67.96 2.00e-136 478.00
IUUC-Laf-054222 Loxodonta africana 100.00 0.00e+00 670.00
IUUC-Mcc-054970 Macaca mulatta 100.00 0.00e+00 670.00
IUUC-Mvi-060482 Microbotryum violaceum 72.29 2.00e-149 521.00
IUUC-Mmr-061302 Microcebus murinus 99.71 0.00e+00 669.00
IUUC-Mdo-062044 Monodelphis domestica 99.41 0.00e+00 665.00
IUUC-Mlu-067309 Myotis lucifugus 100.00 0.00e+00 670.00
IUUC-Nfi-068332 Neosartorya fischeri 68.55 2.00e-137 482.00
IUUC-Nle-069791 Nomascus leucogenys 100.00 0.00e+00 670.00
IUUC-Ont-071280 Oreochromis niloticus 98.24 0.00e+00 693.00
IUUC-Oan-072780 Ornithorhynchus anatinus 98.82 0.00e+00 664.00
IUUC-Ocu-073769 Oryctolagus cuniculus 100.00 0.00e+00 670.00
IUUC-Ola-087490 Oryzias latipes 97.24 0.00e+00 639.00
IUUC-Oga-087961 Otolemur garnettii 100.00 0.00e+00 670.00
IUUC-Pan-092079 Papio anubis 100.00 0.00e+00 670.00
IUUC-Psi-093225 Pelodiscus sinensis 97.94 0.00e+00 657.00
IUUC-Pfo-097028 Poecilia formosa 97.35 0.00e+00 669.00
IUUC-Pab-098658 Pongo abelii 100.00 0.00e+00 670.00
IUUC-Pca-100313 Procavia capensis 99.41 0.00e+00 659.00
IUUC-Pva-102636 Pteropus vampyrus 99.71 0.00e+00 668.00
IUUC-Pgr-103321 Puccinia graminis 73.19 4.00e-150 523.00
IUUC-Ptt-103728 Puccinia triticina 73.19 4.00e-150 523.00
IUUC-Pyt-104426 Pyrenophora triticirepentis 62.83 5.00e-124 437.00
IUUC-Rno-105112 Rattus norvegicus 100.00 0.00e+00 670.00
IUUC-Sha-106856 Sarcophilus harrisii 99.41 0.00e+00 665.00
IUUC-Sre-115035 Sporisorium reilianum 69.97 2.00e-140 491.00
IUUC-Tru-117793 Takifugu rubripes 97.94 0.00e+00 672.00
IUUC-Tni-120495 Tetraodon nigroviridis 97.35 0.00e+00 664.00
IUUC-Tme-126886 Tuber melanosporum 70.36 3.00e-136 478.00
IUUC-Uma-129589 Ustilago maydis 70.27 6.00e-141 493.00
Created Date 25-Jun-2017

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