iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000038905.7	ENSDART00000144837.2	ENSDARP00000116948.1
ENSDARG00000038905.7	ENSDART00000172669.1	ENSDARP00000140400.1
ENSDARG00000038905.7	ENSDART00000056795.6	ENSDARP00000056794.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-72	244.7	522	846

Active Site

Position(s)	Description	Evidence
816	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+      ++d ++ np  ++++ Fe++G+l+g al+ + +l
   Q: 522  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSsecplpLPFFTRTSNQ--GAGEARDFYVPNPscREFNKFEWIGQLMGAALRGKDFL 608
           355****************************999999777777666664..4457788888777779********************** PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeY 173
            l l+  ++k+l+g+ +s+ +d+++vd+ l+k l+ + ++     +++++d++f    v ++ l++ + +eL+pgG+ + V +e++ e+
   Q: 609  VLALPGLVWKQLIGEAVSWtKDFPAVDSVLVKLLEAMDHM-----DKETFDFKFGqelVYTTPLSDGRLVELIPGGSGVVVRYEDRVEF 692
           **************************************77.....55557777764466677799************************ PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  +eq+ a+++G+ +v+p+ +l+l+t++e+e  +cG++ei+ve+lk+ t+y++ +++++  +q++we+l +f++e+r+
   Q: 693  IRLVQKARLEE-NREQISAMQAGLVKVVPQAVLDLLTWQEVEKKVCGDPEITVEALKRLTRYED-LEQTDVRVQYLWEALMNFTNEDRS 779
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+       p  +   k  ++++d lP+s+TC ++L LP+Y+s ++++ekL+yA  ++ +++
   Q: 780  RFLRFVTGRSRLPA-------PIYIFPDKqgSETEDALPQSSTCSSTLYLPKYPSAKVCEEKLRYAAYNCVAID 846
           *************5.......44466666788888*********************************998776 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSPDDNPHTL LGRIRFLNRC IECFRKSEPL PESLCYVAKE VCYKICKDSS SGSTSASSST 60
AGNSGGKSVV SVWDSPHQAP HKKSCRCNIE PKKGTCIRTT GEEYCNSHGL WVKINKEQLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGATCGC CCTTTAGACT GGTGGTGGAG ACACGTAGCT GTCTTGACAG ATGCCAGTAT 60
CCGCGAGAAA GCTCTGGCGG GAGTAACAAA GCTTTACTGT CTCTAAACCT TTGTTACGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	69.64	0.00e+00	1221.00
IUUC-Apl-003715	Anas platyrhynchos	78.81	0.00e+00	1210.00
IUUC-Aca-004377	Anolis carolinensis	72.88	0.00e+00	1283.00
IUUC-Ame-011918	Astyanax mexicanus	82.11	0.00e+00	1434.00
IUUC-Bta-012736	Bos taurus	70.34	0.00e+00	1236.00
IUUC-Cja-019926	Callithrix jacchus	70.11	0.00e+00	1232.00
IUUC-Cfa-020753	Canis familiaris	78.51	0.00e+00	962.00
IUUC-Cpo-021415	Cavia porcellus	70.11	0.00e+00	1229.00
IUUC-Csa-023096	Chlorocebus sabaeus	69.75	0.00e+00	1227.00
IUUC-Dno-029293	Dasypus novemcinctus	78.91	0.00e+00	883.00
IUUC-Dor-031113	Dipodomys ordii	78.02	0.00e+00	1008.00
IUUC-Ete-032601	Echinops telfairi	68.35	0.00e+00	1080.00
IUUC-Eca-034198	Equus caballus	69.13	0.00e+00	1228.00
IUUC-Eeu-034708	Erinaceus europaeus	78.57	0.00e+00	745.00
IUUC-Fca-035478	Felis catus	70.81	0.00e+00	1226.00
IUUC-Fal-037366	Ficedula albicollis	72.64	0.00e+00	1254.00
IUUC-Gmo-039020	Gadus morhua	88.23	0.00e+00	1199.00
IUUC-Gga-040332	Gallus gallus	75.21	0.00e+00	1308.00
IUUC-Gac-042336	Gasterosteus aculeatus	85.20	0.00e+00	1515.00
IUUC-Ggo-045382	Gorilla gorilla	69.87	0.00e+00	1227.00
IUUC-Hsa-046562	Homo sapiens	69.87	0.00e+00	1227.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	70.11	0.00e+00	1230.00
IUUC-Lch-049606	Latimeria chalumnae	65.16	0.00e+00	815.00
IUUC-Loc-052448	Lepisosteus oculatus	73.52	0.00e+00	1260.00
IUUC-Laf-054507	Loxodonta africana	69.91	0.00e+00	1243.00
IUUC-Mcc-055690	Macaca mulatta	69.75	0.00e+00	1226.00
IUUC-Meu-055970	Macropus eugenii	70.30	0.00e+00	1209.00
IUUC-Mga-059654	Meleagris gallopavo	79.04	0.00e+00	1192.00
IUUC-Mmr-061069	Microcebus murinus	69.99	0.00e+00	1228.00
IUUC-Mdo-062547	Monodelphis domestica	80.61	0.00e+00	697.00
IUUC-Mmu-063096	Mus musculus	69.87	0.00e+00	1227.00
IUUC-Mpu-065846	Mustela putorius furo	69.87	0.00e+00	1229.00
IUUC-Mlu-067992	Myotis lucifugus	74.12	0.00e+00	1206.00
IUUC-Nle-069565	Nomascus leucogenys	68.70	0.00e+00	1134.00
IUUC-Opr-070853	Ochotona princeps	65.56	0.00e+00	806.00
IUUC-Ont-071628	Oreochromis niloticus	86.64	0.00e+00	1494.00
IUUC-Ocu-074094	Oryctolagus cuniculus	69.99	0.00e+00	1230.00
IUUC-Ola-087384	Oryzias latipes	85.38	0.00e+00	1509.00
IUUC-Oga-088224	Otolemur garnettii	69.75	0.00e+00	1233.00
IUUC-Oar-090043	Ovis aries	68.15	0.00e+00	1172.00
IUUC-Ptr-090852	Pan troglodytes	69.64	0.00e+00	1218.00
IUUC-Pan-092787	Papio anubis	69.75	0.00e+00	1226.00
IUUC-Psi-092986	Pelodiscus sinensis	67.58	0.00e+00	904.00
IUUC-Pma-094416	Petromyzon marinus	39.62	7.00e-175	607.00
IUUC-Pfo-096720	Poecilia formosa	86.57	0.00e+00	1543.00
IUUC-Pab-098325	Pongo abelii	66.72	0.00e+00	907.00
IUUC-Pca-100885	Procavia capensis	63.59	0.00e+00	939.00
IUUC-Pva-102829	Pteropus vampyrus	58.11	0.00e+00	724.00
IUUC-Rno-104882	Rattus norvegicus	70.22	0.00e+00	1234.00
IUUC-Sha-106811	Sarcophilus harrisii	77.83	6.00e-99	354.00
IUUC-Sar-113020	Sorex araneus	69.52	5.00e-171	595.00
IUUC-Ssc-115436	Sus scrofa	70.22	2.00e-115	408.00
IUUC-Tgu-117042	Taeniopygia guttata	75.21	0.00e+00	1310.00
IUUC-Tru-118419	Takifugu rubripes	82.84	0.00e+00	1403.00
IUUC-Tsy-118829	Tarsius syrichta	70.02	0.00e+00	739.00
IUUC-Tni-120410	Tetraodon nigroviridis	71.65	0.00e+00	1151.00
IUUC-Tbe-128113	Tupaia belangeri	79.32	0.00e+00	639.00
IUUC-Ttr-128167	Tursiops truncatus	66.63	0.00e+00	1147.00
IUUC-Xtr-132910	Xenopus tropicalis	63.94	0.00e+00	1069.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence