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Tag Content
UUCD2 ID IUUC-Dre-027650
UUCD1 version UUC-DaR-00133
Ensembl Protein ID ENSDARP00000055490.4
UniProt Accession A9JRZ0; SMUF2_DANRE
Genbank Protein ID AAI55850.1
Protein Name E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
Genbank Nucleotide ID BC155849
Gene Name smurf2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000038067.5 ENSDART00000055491.5 ENSDARP00000055490.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.60e-129 431.2 432 764
Active Site
Position(s) Description Evidence
733 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 432  PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 519
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt++ k+eYv+l+v+
   Q: 520  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYVN 604
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+ds+ ++wFw+++e+ ++e r+++LqFv
   Q: 605  WRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKH-CTPDSNIVKWFWRAVESYDEERRARLLQFV 692
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+++l++kLl+Aieet gF +
   Q: 693  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAV 764
           **********************************************************************76 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MSNQGVRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNSINRLKDT GYQRLDLNKL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027650|E3,HECT|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCACATCCG GGCCACAGGA CCGTGACTCC ATTATTTTCT GTTCACTGTG AAACTGGCGT 60
TGAGGGGAAC CAAAAAGCAA CTCTGTAACA CATTCGACCC GTTTTTTGTA GTAGTCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027650|E3,HECT|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
KEGG dre:563633
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001305 Ailuropoda melanoleuca 89.89 0.00e+00 1407.00
IUUC-Apl-003513 Anas platyrhynchos 91.46 0.00e+00 1426.00
IUUC-Aca-005358 Anolis carolinensis 91.24 0.00e+00 1448.00
IUUC-Ame-011320 Astyanax mexicanus 90.52 0.00e+00 1456.00
IUUC-Bta-013399 Bos taurus 90.91 0.00e+00 1407.00
IUUC-Cja-019355 Callithrix jacchus 90.04 0.00e+00 1408.00
IUUC-Cpo-022200 Cavia porcellus 90.40 0.00e+00 1411.00
IUUC-Cho-024804 Choloepus hoffmanni 94.50 5.00e-180 624.00
IUUC-Cin-025126 Ciona intestinalis 63.95 0.00e+00 968.00
IUUC-Csv-026339 Ciona savignyi 63.06 0.00e+00 1005.00
IUUC-Dno-029534 Dasypus novemcinctus 90.33 0.00e+00 1433.00
IUUC-Ete-032715 Echinops telfairi 85.81 0.00e+00 1318.00
IUUC-Eca-033580 Equus caballus 90.40 0.00e+00 1410.00
IUUC-Eeu-034945 Erinaceus europaeus 88.38 0.00e+00 1310.00
IUUC-Fal-037275 Ficedula albicollis 90.50 0.00e+00 1420.00
IUUC-Gmo-039234 Gadus morhua 84.56 0.00e+00 761.00
IUUC-Gga-041060 Gallus gallus 87.97 0.00e+00 1382.00
IUUC-Gac-041295 Gasterosteus aculeatus 92.24 0.00e+00 1446.00
IUUC-Hsa-046726 Homo sapiens 90.46 0.00e+00 1433.00
IUUC-Lch-050026 Latimeria chalumnae 90.72 0.00e+00 1438.00
IUUC-Loc-051760 Lepisosteus oculatus 91.03 0.00e+00 1438.00
IUUC-Laf-053753 Loxodonta africana 90.25 0.00e+00 1407.00
IUUC-Mcc-054815 Macaca mulatta 90.20 0.00e+00 1429.00
IUUC-Meu-056436 Macropus eugenii 69.84 0.00e+00 1041.00
IUUC-Mmr-060806 Microcebus murinus 90.13 0.00e+00 1408.00
IUUC-Mdo-062805 Monodelphis domestica 90.07 0.00e+00 1420.00
IUUC-Mmu-064034 Mus musculus 90.72 0.00e+00 1433.00
IUUC-Mpu-066762 Mustela putorius furo 89.89 0.00e+00 1407.00
IUUC-Mlu-066981 Myotis lucifugus 90.25 0.00e+00 1407.00
IUUC-Nle-069804 Nomascus leucogenys 90.54 0.00e+00 1427.00
IUUC-Opr-070591 Ochotona princeps 85.94 0.00e+00 1310.00
IUUC-Ont-072243 Oreochromis niloticus 93.56 0.00e+00 1498.00
IUUC-Oan-072699 Ornithorhynchus anatinus 89.74 0.00e+00 1434.00
IUUC-Ocu-074913 Oryctolagus cuniculus 90.46 0.00e+00 1434.00
IUUC-Ola-086597 Oryzias latipes 85.79 0.00e+00 1318.00
IUUC-Oga-089116 Otolemur garnettii 87.18 0.00e+00 1349.00
IUUC-Oar-089366 Ovis aries 90.67 0.00e+00 1407.00
IUUC-Ptr-091382 Pan troglodytes 90.46 0.00e+00 1433.00
IUUC-Psi-093298 Pelodiscus sinensis 90.25 0.00e+00 1407.00
IUUC-Pma-094354 Petromyzon marinus 72.49 0.00e+00 1135.00
IUUC-Pfo-096071 Poecilia formosa 94.03 0.00e+00 1489.00
IUUC-Pab-098682 Pongo abelii 90.46 0.00e+00 1431.00
IUUC-Pca-100516 Procavia capensis 85.47 4.00e-177 615.00
IUUC-Pva-102754 Pteropus vampyrus 89.29 0.00e+00 1370.00
IUUC-Rno-105600 Rattus norvegicus 89.28 0.00e+00 1211.00
IUUC-Sha-107144 Sarcophilus harrisii 89.68 0.00e+00 1287.00
IUUC-Sja-107941 Schizosaccharomyces japonicus 38.03 9.00e-156 544.00
IUUC-Spo-108171 Schizosaccharomyces pombe 39.42 4.00e-161 561.00
IUUC-Sar-113122 Sorex araneus 79.92 0.00e+00 1196.00
IUUC-Tgu-117112 Taeniopygia guttata 91.11 0.00e+00 1446.00
IUUC-Tru-118497 Takifugu rubripes 90.69 0.00e+00 1417.00
IUUC-Tni-120781 Tetraodon nigroviridis 89.71 0.00e+00 1214.00
IUUC-Tme-126897 Tuber melanosporum 38.36 4.00e-152 532.00
IUUC-Tbe-127371 Tupaia belangeri 80.76 0.00e+00 1148.00
IUUC-Ttr-129305 Tursiops truncatus 84.59 0.00e+00 1214.00
IUUC-Vpa-130591 Vicugna pacos 80.86 0.00e+00 1216.00
IUUC-Xtr-132979 Xenopus tropicalis 73.47 0.00e+00 1076.00
Created Date 25-Jun-2017

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