iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Acl-008273

Ensembl Protein ID

CADACLAP00001699

UniProt Accession

A1CQG2; RSP5_ASPCL

Genbank Protein ID

EAW07883.1

Protein Name

Probable E3 ubiquitin-protein ligase hulA; HECT ubiquitin ligase A; HECT-type E3 ubiquitin transferase hulA

Genbank Nucleotide ID

DS027059

Gene Name

ACLA_026000; hulA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADACLAG00001746	CADACLAT00001746	CADACLAP00001699

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-124	414.3	513	844

Active Site

Position(s)	Description	Evidence
783	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           +sdlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld ++  
   Q: 513  ASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGV-NPEHLNYFKFIGRVVGLAIFHRRFLDSFFIG 604
           689*********************************************************9.89***************************** PP
   S: 95   sfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegik 187
           +fyk++l+kk+sl+d+e vd++l+++l++ ++n   die   l+ltf v++e++ge+++ +LkpgG++ipVtneNk eYv+lv+e+++ ++++
   Q: 605  AFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLDN---DIEGV-LELTFAVDDEKFGERRTIDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVE 693
           *******************************99...9***8.*************************************************** PP
   S: 188  eqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfa 280
           eq++af +Gfne+ip +l+++F+e+elelli G ++idv+d+kk+t y+g y+e++ +iq+Fw+v++ +++e+++++LqF+Tg+sr+P++Gf+
   Q: 694  EQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRG-YQESDDVIQNFWKVVRTWDAEQKSRLLQFTTGTSRIPVNGFK 785
           ************************************************76.****************************************** PP
   S: 281  elk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +l+    pr+f+i+k++++  lP+s+TCfn+L+LP+Y+++e+l++k+ +A+eet gF++
   Q: 786  DLQgsdgPRRFTIEKSGDPVALPKSHTCFNRLDLPPYKTYETLEHKMSIAVEETLGFGQ 844
           *********************************************************86 PP

Organism

Aspergillus clavatus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.

Protein Sequence
(Fasta)

MMTVPMLRPV DLTVVKLFAT NPLNHYNSRS RNSLTRIQPN LRLTIIAADG LYKRDVFRFP 60
DPFAVATVGG EQTQTTSVIK KTLNPYWNEM FDLRVNEESI LAIQIFDQKK FKKKDQGFLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATGACCG TGCCAATGTT ACGCCCCGTG GACCTCACAG TAGTTAAGTA AGCCGTAGTT 60
ATATGGGACA CAAAAGTCCT TTTCCTTTTT TTTTTTTTTT TTTTTTTTTT TTTTTTTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043328--P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0016567--P:protein ubiquitination

KEGG

act:ACLA_026000

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	48.50	8.00e-159	552.00
IUUC-Apl-003893	Anas platyrhynchos	48.00	2.00e-155	541.00
IUUC-Aca-005338	Anolis carolinensis	47.47	2.00e-155	541.00
IUUC-Ago-007742	Ashbya gossypii	74.92	0.00e+00	921.00
IUUC-Afl-008713	Aspergillus flavus	93.84	0.00e+00	1446.00
IUUC-Afu-009103	Aspergillus fumigatus	92.08	0.00e+00	1420.00
IUUC-Ani-009259	Aspergillus nidulans	88.70	0.00e+00	1407.00
IUUC-Ang-009738	Aspergillus niger	92.26	0.00e+00	1440.00
IUUC-Aor-010053	Aspergillus oryzae	96.99	2.00e-177	612.00
IUUC-Ate-010529	Aspergillus terreus	93.81	0.00e+00	1459.00
IUUC-Ame-010810	Astyanax mexicanus	52.26	7.00e-146	509.00
IUUC-Bgr-012148	Blumeria graminis	72.85	0.00e+00	1100.00
IUUC-Bta-012679	Bos taurus	48.50	6.00e-159	553.00
IUUC-Bci-013785	Botrytis cinerea	73.80	0.00e+00	1170.00
IUUC-Cel-018299	Caenorhabditis elegans	45.55	9.00e-150	522.00
IUUC-Cja-018732	Callithrix jacchus	48.50	2.00e-159	554.00
IUUC-Cfa-021226	Canis familiaris	48.50	1.00e-158	552.00
IUUC-Cpo-021671	Cavia porcellus	48.50	4.00e-159	553.00
IUUC-Csa-023344	Chlorocebus sabaeus	46.93	3.00e-155	540.00
IUUC-Cho-024695	Choloepus hoffmanni	48.32	1.00e-157	548.00
IUUC-Cin-025212	Ciona intestinalis	49.48	3.00e-142	497.00
IUUC-Csv-026256	Ciona savignyi	44.09	2.00e-142	497.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	72.82	0.00e+00	1105.00
IUUC-Cne-026849	Cryptococcus neoformans	70.51	0.00e+00	867.00
IUUC-Dre-027770	Danio rerio	52.67	3.00e-147	514.00
IUUC-Dno-029466	Dasypus novemcinctus	48.50	5.00e-159	553.00
IUUC-Dor-030138	Dipodomys ordii	47.83	2.00e-154	537.00
IUUC-Dse-031241	Dothistroma septosporum	75.15	0.00e+00	1196.00
IUUC-Dme-032041	Drosophila melanogaster	46.00	6.00e-144	503.00
IUUC-Ete-033145	Echinops telfairi	45.67	2.00e-146	511.00
IUUC-Eca-033445	Equus caballus	48.50	8.00e-159	552.00
IUUC-Eeu-035247	Erinaceus europaeus	48.33	2.00e-158	551.00
IUUC-Fca-036384	Felis catus	48.47	7.00e-159	553.00
IUUC-Fal-037604	Ficedula albicollis	46.37	1.00e-151	528.00
IUUC-Fox-037774	Fusarium oxysporum	73.25	0.00e+00	1129.00
IUUC-Fso-038393	Fusarium solani	72.33	0.00e+00	1098.00
IUUC-Gmo-039674	Gadus morhua	52.26	2.00e-145	508.00
IUUC-Ggr-040107	Gaeumannomyces graminis	71.41	0.00e+00	1139.00
IUUC-Gga-041276	Gallus gallus	47.83	1.00e-154	538.00
IUUC-Gac-042020	Gasterosteus aculeatus	48.91	1.00e-155	541.00
IUUC-Ggo-045332	Gorilla gorilla	48.50	1.00e-158	551.00
IUUC-Hsa-045968	Homo sapiens	48.50	6.00e-159	553.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	47.98	2.00e-157	547.00
IUUC-Kpa-049273	Komagataella pastoris	66.38	0.00e+00	1038.00
IUUC-Lch-050443	Latimeria chalumnae	48.33	3.00e-157	546.00
IUUC-Loc-052662	Lepisosteus oculatus	52.26	1.00e-142	499.00
IUUC-Lma-052980	Leptosphaeria maculans	72.88	0.00e+00	693.00
IUUC-Laf-053850	Loxodonta africana	48.50	8.00e-159	552.00
IUUC-Mcc-055821	Macaca mulatta	48.50	4.00e-159	553.00
IUUC-Meu-055953	Macropus eugenii	40.37	2.00e-118	418.00
IUUC-Mor-057097	Magnaporthe oryzae	72.67	0.00e+00	1147.00
IUUC-Mpo-057442	Magnaporthe poae	68.86	0.00e+00	1016.00
IUUC-Mla-058996	Melampsora laricipopulina	78.17	0.00e+00	811.00
IUUC-Mga-059362	Meleagris gallopavo	47.39	8.00e-153	532.00
IUUC-Mvi-060395	Microbotryum violaceum	78.79	0.00e+00	819.00
IUUC-Mmr-061061	Microcebus murinus	47.79	7.00e-161	560.00
IUUC-Mdo-062173	Monodelphis domestica	44.87	2.00e-154	538.00
IUUC-Mmu-064136	Mus musculus	48.50	6.00e-159	553.00
IUUC-Mpu-066765	Mustela putorius furo	48.50	1.00e-158	551.00
IUUC-Mlu-067565	Myotis lucifugus	48.50	2.00e-158	550.00
IUUC-Nfi-068427	Neosartorya fischeri	95.67	0.00e+00	1463.00
IUUC-Ncr-068918	Neurospora crassa	78.89	0.00e+00	933.00
IUUC-Nle-069070	Nomascus leucogenys	47.42	4.00e-153	533.00
IUUC-Opr-071044	Ochotona princeps	48.33	3.00e-158	550.00
IUUC-Ont-071664	Oreochromis niloticus	46.51	9.00e-146	509.00
IUUC-Oan-073019	Ornithorhynchus anatinus	46.60	2.00e-149	520.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.42	2.00e-158	551.00
IUUC-Ola-087467	Oryzias latipes	47.46	5.00e-155	540.00
IUUC-Oga-088460	Otolemur garnettii	48.50	8.00e-159	552.00
IUUC-Oar-090198	Ovis aries	48.50	6.00e-159	553.00
IUUC-Ptr-090939	Pan troglodytes	48.50	6.00e-159	553.00
IUUC-Pan-092284	Papio anubis	48.50	7.00e-159	552.00
IUUC-Psi-093645	Pelodiscus sinensis	47.99	4.00e-157	546.00
IUUC-Pma-094364	Petromyzon marinus	51.84	4.00e-143	499.00
IUUC-Pno-095118	Phaeosphaeria nodorum	74.35	0.00e+00	1182.00
IUUC-Pfo-097145	Poecilia formosa	47.20	6.00e-152	529.00
IUUC-Pab-098088	Pongo abelii	48.50	7.00e-159	552.00
IUUC-Pca-100568	Procavia capensis	45.59	7.00e-138	483.00
IUUC-Pva-102354	Pteropus vampyrus	48.33	5.00e-158	550.00
IUUC-Pgr-103620	Puccinia graminis	77.75	0.00e+00	800.00
IUUC-Ptt-103806	Puccinia triticina	78.54	0.00e+00	687.00
IUUC-Pte-104016	Pyrenophora teres	75.93	0.00e+00	1198.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	75.93	0.00e+00	1198.00
IUUC-Rno-105318	Rattus norvegicus	48.50	5.00e-159	553.00
IUUC-Sce-106289	Saccharomyces cerevisiae	74.58	0.00e+00	921.00
IUUC-Sha-107482	Sarcophilus harrisii	45.43	2.00e-156	544.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	64.68	0.00e+00	1020.00
IUUC-Spo-108171	Schizosaccharomyces pombe	63.09	0.00e+00	971.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	81.30	0.00e+00	989.00
IUUC-Sar-113761	Sorex araneus	47.98	9.00e-157	545.00
IUUC-Sre-114929	Sporisorium reilianum	71.19	0.00e+00	874.00
IUUC-Ssc-115368	Sus scrofa	44.13	5.00e-148	516.00
IUUC-Tgu-117130	Taeniopygia guttata	48.00	2.00e-155	541.00
IUUC-Tru-118610	Takifugu rubripes	54.53	7.00e-154	536.00
IUUC-Tsy-119492	Tarsius syrichta	48.09	4.00e-156	543.00
IUUC-Tni-119993	Tetraodon nigroviridis	46.82	5.00e-150	523.00
IUUC-Tre-122203	Trichoderma reesei	72.41	0.00e+00	1097.00
IUUC-Tvi-122595	Trichoderma virens	71.06	0.00e+00	1118.00
IUUC-Tme-126897	Tuber melanosporum	77.85	0.00e+00	917.00
IUUC-Tbe-127793	Tupaia belangeri	47.63	3.00e-131	461.00
IUUC-Ttr-128235	Tursiops truncatus	53.29	1.00e-148	518.00
IUUC-Uma-129332	Ustilago maydis	71.11	0.00e+00	838.00
IUUC-Vda-129753	Verticillium dahliae	69.55	0.00e+00	1064.00
IUUC-Vpa-130503	Vicugna pacos	50.52	2.00e-138	485.00
IUUC-Xtr-132859	Xenopus tropicalis	48.33	2.00e-158	551.00
IUUC-Xma-133797	Xiphophorus maculatus	48.84	1.00e-157	548.00
IUUC-Yli-134668	Yarrowia lipolytica	74.28	0.00e+00	939.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence