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Tag Content
UUCD2 ID IUUC-Mlu-067565
UUCD1 version UUC-MyL-00252
Ensembl Protein ID ENSMLUP00000004528.2
UniProt Accession G1P3M4; G1P3M4_MYOLU
Genbank Protein ID ENSMLUP00000004528
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPE02014584
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000004954.2 ENSMLUT00000004966.2 ENSMLUP00000004528.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.20e-136 453.8 544 875
Active Site
Position(s) Description Evidence
845 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 544  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 632
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 633  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 716
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 717  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 805
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 806  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 875
           *********************************************************************8 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
TRDDFLGQVD VPLNHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENSEQRED MEHGWEVVDS NDSASQHQEE LPPPLPPGWE EKVDNLGRTY YVNHNNRSTQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-067565|E3,HECT|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACACGAGACG ACTTCCTGGG ACAGGTGGAC GTGCCCCTTA ATCATCTCCC GGTGAGGATG 60
GTTACCTGCT TTCTATTGCC TGTTGTGATC AGTGACTTCT CATTGTTTTC AGCTGGATAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-067565|E3,HECT|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 93.63 0.00e+00 1551.00
IUUC-Apl-003893 Anas platyrhynchos 91.92 0.00e+00 1556.00
IUUC-Aca-004744 Anolis carolinensis 89.43 0.00e+00 1503.00
IUUC-Ago-007742 Ashbya gossypii 49.41 8.00e-163 567.00
IUUC-Acl-008273 Aspergillus clavatus 49.26 6.00e-163 567.00
IUUC-Afl-008713 Aspergillus flavus 49.01 8.00e-161 560.00
IUUC-Afu-009103 Aspergillus fumigatus 49.02 6.00e-163 568.00
IUUC-Ani-009259 Aspergillus nidulans 49.16 4.00e-161 561.00
IUUC-Ang-009738 Aspergillus niger 49.33 1.00e-161 563.00
IUUC-Aor-010053 Aspergillus oryzae 58.39 8.00e-102 363.00
IUUC-Ate-010529 Aspergillus terreus 49.42 1.00e-163 570.00
IUUC-Ame-010810 Astyanax mexicanus 70.01 0.00e+00 1137.00
IUUC-Bgr-012148 Blumeria graminis 48.09 5.00e-154 538.00
IUUC-Bta-012679 Bos taurus 95.90 0.00e+00 1585.00
IUUC-Cel-018564 Caenorhabditis elegans 53.18 0.00e+00 635.00
IUUC-Cja-018732 Callithrix jacchus 95.79 0.00e+00 1620.00
IUUC-Cfa-021226 Canis familiaris 95.45 0.00e+00 1611.00
IUUC-Cpo-021671 Cavia porcellus 92.95 0.00e+00 1546.00
IUUC-Csa-023344 Chlorocebus sabaeus 93.76 0.00e+00 1591.00
IUUC-Cho-024832 Choloepus hoffmanni 99.43 0.00e+00 740.00
IUUC-Csv-026098 Ciona savignyi 59.04 0.00e+00 654.00
IUUC-Dre-027770 Danio rerio 78.84 0.00e+00 1273.00
IUUC-Dno-029466 Dasypus novemcinctus 95.45 0.00e+00 1610.00
IUUC-Dor-030138 Dipodomys ordii 91.65 0.00e+00 1497.00
IUUC-Dse-031241 Dothistroma septosporum 47.70 1.00e-159 557.00
IUUC-Ete-033145 Echinops telfairi 86.55 0.00e+00 1262.00
IUUC-Eca-033445 Equus caballus 95.79 0.00e+00 1566.00
IUUC-Eeu-035247 Erinaceus europaeus 87.37 0.00e+00 1387.00
IUUC-Fca-035489 Felis catus 93.56 0.00e+00 1529.00
IUUC-Fal-037604 Ficedula albicollis 89.41 0.00e+00 1540.00
IUUC-Fox-037774 Fusarium oxysporum 48.76 2.00e-158 552.00
IUUC-Gmo-039674 Gadus morhua 76.86 0.00e+00 1244.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.50 8.00e-156 544.00
IUUC-Gga-040703 Gallus gallus 91.13 0.00e+00 1554.00
IUUC-Gac-042020 Gasterosteus aculeatus 79.19 0.00e+00 1269.00
IUUC-Ggo-045332 Gorilla gorilla 93.74 0.00e+00 1581.00
IUUC-Hsa-045968 Homo sapiens 95.79 0.00e+00 1605.00
IUUC-Lch-050443 Latimeria chalumnae 87.49 0.00e+00 1449.00
IUUC-Loc-052662 Lepisosteus oculatus 81.36 0.00e+00 1293.00
IUUC-Laf-053850 Loxodonta africana 93.17 0.00e+00 1588.00
IUUC-Mcc-055821 Macaca mulatta 95.68 0.00e+00 1603.00
IUUC-Meu-056712 Macropus eugenii 79.42 0.00e+00 681.00
IUUC-Mor-057097 Magnaporthe oryzae 47.50 1.00e-156 546.00
IUUC-Mla-058996 Melampsora laricipopulina 54.55 3.00e-150 526.00
IUUC-Mga-059264 Meleagris gallopavo 71.68 0.00e+00 1052.00
IUUC-Mvi-060395 Microbotryum violaceum 53.91 1.00e-150 527.00
IUUC-Mmr-060798 Microcebus murinus 91.38 0.00e+00 1478.00
IUUC-Mdo-062173 Monodelphis domestica 92.43 0.00e+00 1605.00
IUUC-Mmu-064136 Mus musculus 94.77 0.00e+00 1570.00
IUUC-Mpu-066765 Mustela putorius furo 96.02 0.00e+00 1588.00
IUUC-Nfi-068427 Neosartorya fischeri 49.02 2.00e-163 569.00
IUUC-Nle-069070 Nomascus leucogenys 91.82 0.00e+00 1513.00
IUUC-Opr-071044 Ochotona princeps 95.67 0.00e+00 1194.00
IUUC-Ont-072044 Oreochromis niloticus 77.74 0.00e+00 1309.00
IUUC-Oan-073032 Ornithorhynchus anatinus 90.53 0.00e+00 1416.00
IUUC-Ocu-074160 Oryctolagus cuniculus 92.16 0.00e+00 1529.00
IUUC-Ola-087467 Oryzias latipes 78.65 0.00e+00 1295.00
IUUC-Oga-088460 Otolemur garnettii 92.26 0.00e+00 1549.00
IUUC-Oar-090198 Ovis aries 95.11 0.00e+00 1568.00
IUUC-Ptr-090939 Pan troglodytes 95.79 0.00e+00 1605.00
IUUC-Pan-092284 Papio anubis 95.68 0.00e+00 1602.00
IUUC-Psi-093645 Pelodiscus sinensis 92.04 0.00e+00 1556.00
IUUC-Pma-094364 Petromyzon marinus 82.63 0.00e+00 860.00
IUUC-Pno-095118 Phaeosphaeria nodorum 47.73 2.00e-163 569.00
IUUC-Pab-098088 Pongo abelii 95.79 0.00e+00 1605.00
IUUC-Pca-100714 Procavia capensis 76.68 0.00e+00 1229.00
IUUC-Pva-102354 Pteropus vampyrus 93.63 0.00e+00 1553.00
IUUC-Pgr-103620 Puccinia graminis 53.73 2.00e-148 519.00
IUUC-Ptt-103806 Puccinia triticina 53.62 2.00e-123 436.00
IUUC-Rno-105318 Rattus norvegicus 94.89 0.00e+00 1572.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.58 5.00e-165 574.00
IUUC-Sha-107482 Sarcophilus harrisii 95.24 0.00e+00 1607.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 48.67 1.00e-157 550.00
IUUC-Sre-114929 Sporisorium reilianum 52.27 5.00e-148 518.00
IUUC-Ssc-115950 Sus scrofa 70.80 0.00e+00 1165.00
IUUC-Tgu-117130 Taeniopygia guttata 91.92 0.00e+00 1560.00
IUUC-Tru-118610 Takifugu rubripes 79.14 0.00e+00 1313.00
IUUC-Tsy-119492 Tarsius syrichta 93.06 0.00e+00 1574.00
IUUC-Tni-120113 Tetraodon nigroviridis 73.89 0.00e+00 1245.00
IUUC-Tre-122203 Trichoderma reesei 47.45 8.00e-152 531.00
IUUC-Ttr-128235 Tursiops truncatus 98.38 0.00e+00 1081.00
IUUC-Vda-129753 Verticillium dahliae 47.85 8.00e-157 547.00
IUUC-Xtr-132859 Xenopus tropicalis 88.52 0.00e+00 1499.00
IUUC-Xma-133797 Xiphophorus maculatus 79.64 0.00e+00 1304.00
IUUC-Yli-134668 Yarrowia lipolytica 46.42 1.00e-161 563.00
Created Date 25-Jun-2017

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