iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000004919.2	ENSSSCT00000005429.2	ENSSSCP00000005294.2
ENSSSCG00000004919.2	ENSSSCT00000005428.2	ENSSSCP00000005293.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-135	451.3	540	871

Active Site

Position(s)	Description	Evidence
841	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 540  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 628
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 629  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 712
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 713  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 801
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 802  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 871
           *********************************************************************8 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

FLSSQQTRDD FLGQVDIPLS HLPTEDPTME RPYTFKDFLL RPRSHKSRVK GFLRLKMAYM 60
PKNGGQDEEN SEQRDEMEPG WEVVDSNDSA SQHQEELPPP PLPPGWEEKV DNLGRTYYVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTCTCTT CTCAACAGAC ACGAGACGAC TTCCTGGGAC AGGTGGACAT ACCCCTTAGT 60
CATCTCCCGG TAAGAATGGT TACCTGCTTT ACAGTGCATG CTGTGAGCAG CAATTTCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	78.88	0.00e+00	928.00
IUUC-Apl-003893	Anas platyrhynchos	68.58	0.00e+00	1130.00
IUUC-Aca-004744	Anolis carolinensis	65.32	0.00e+00	1075.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	8.00e-102	362.00
IUUC-Ame-010810	Astyanax mexicanus	86.90	0.00e+00	867.00
IUUC-Bta-012679	Bos taurus	71.97	0.00e+00	1167.00
IUUC-Cel-018564	Caenorhabditis elegans	55.56	1.00e-159	556.00
IUUC-Cja-018732	Callithrix jacchus	71.11	0.00e+00	1166.00
IUUC-Cfa-021226	Canis familiaris	70.12	0.00e+00	1160.00
IUUC-Cpo-021671	Cavia porcellus	70.87	0.00e+00	1159.00
IUUC-Csa-023344	Chlorocebus sabaeus	68.29	0.00e+00	1148.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	741.00
IUUC-Cin-025157	Ciona intestinalis	70.00	0.00e+00	727.00
IUUC-Csv-026098	Ciona savignyi	65.01	5.00e-171	593.00
IUUC-Dre-027770	Danio rerio	89.14	0.00e+00	882.00
IUUC-Dno-029466	Dasypus novemcinctus	70.93	0.00e+00	1169.00
IUUC-Dor-030138	Dipodomys ordii	69.51	0.00e+00	1096.00
IUUC-Dme-032166	Drosophila melanogaster	61.75	0.00e+00	672.00
IUUC-Ete-033145	Echinops telfairi	70.61	0.00e+00	837.00
IUUC-Eca-033445	Equus caballus	70.89	0.00e+00	1160.00
IUUC-Eeu-035247	Erinaceus europaeus	87.01	0.00e+00	924.00
IUUC-Fca-035489	Felis catus	68.60	0.00e+00	1099.00
IUUC-Fal-037604	Ficedula albicollis	66.41	0.00e+00	1105.00
IUUC-Gmo-039674	Gadus morhua	87.66	0.00e+00	864.00
IUUC-Gga-040703	Gallus gallus	67.92	0.00e+00	1127.00
IUUC-Gac-042020	Gasterosteus aculeatus	88.49	0.00e+00	868.00
IUUC-Ggo-045332	Gorilla gorilla	71.57	0.00e+00	1151.00
IUUC-Hsa-045968	Homo sapiens	69.76	0.00e+00	1162.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	70.20	0.00e+00	764.00
IUUC-Lch-050443	Latimeria chalumnae	66.25	0.00e+00	1061.00
IUUC-Loc-052662	Lepisosteus oculatus	87.16	0.00e+00	857.00
IUUC-Laf-053850	Loxodonta africana	71.64	0.00e+00	1157.00
IUUC-Mcc-055821	Macaca mulatta	69.76	0.00e+00	1160.00
IUUC-Meu-056897	Macropus eugenii	83.62	9.00e-149	520.00
IUUC-Mga-059362	Meleagris gallopavo	71.45	0.00e+00	774.00
IUUC-Mmr-060798	Microcebus murinus	65.24	0.00e+00	1037.00
IUUC-Mdo-062173	Monodelphis domestica	67.56	0.00e+00	1145.00
IUUC-Mmu-064136	Mus musculus	70.67	0.00e+00	1165.00
IUUC-Mpu-066765	Mustela putorius furo	71.28	0.00e+00	1164.00
IUUC-Mlu-067565	Myotis lucifugus	70.91	0.00e+00	1140.00
IUUC-Nle-069070	Nomascus leucogenys	65.46	0.00e+00	1065.00
IUUC-Opr-071044	Ochotona princeps	87.01	0.00e+00	923.00
IUUC-Ont-072044	Oreochromis niloticus	88.28	0.00e+00	901.00
IUUC-Oan-073032	Ornithorhynchus anatinus	65.14	0.00e+00	991.00
IUUC-Ocu-074160	Oryctolagus cuniculus	87.20	0.00e+00	928.00
IUUC-Ola-087467	Oryzias latipes	62.83	0.00e+00	1007.00
IUUC-Oga-088460	Otolemur garnettii	70.64	0.00e+00	1159.00
IUUC-Oar-090198	Ovis aries	71.06	0.00e+00	1167.00
IUUC-Ptr-090939	Pan troglodytes	69.76	0.00e+00	1162.00
IUUC-Pan-092284	Papio anubis	69.76	0.00e+00	1163.00
IUUC-Psi-093645	Pelodiscus sinensis	69.78	0.00e+00	1119.00
IUUC-Pma-094364	Petromyzon marinus	80.42	0.00e+00	805.00
IUUC-Pfo-096768	Poecilia formosa	88.12	0.00e+00	867.00
IUUC-Pab-098088	Pongo abelii	69.76	0.00e+00	1162.00
IUUC-Pca-100714	Procavia capensis	70.94	0.00e+00	789.00
IUUC-Pva-102354	Pteropus vampyrus	78.65	0.00e+00	928.00
IUUC-Rno-105318	Rattus norvegicus	70.82	0.00e+00	1164.00
IUUC-Sha-107482	Sarcophilus harrisii	71.04	0.00e+00	1157.00
IUUC-Sar-113394	Sorex araneus	100.00	1.00e-128	454.00
IUUC-Tgu-117130	Taeniopygia guttata	68.25	0.00e+00	1130.00
IUUC-Tru-118610	Takifugu rubripes	63.44	0.00e+00	1041.00
IUUC-Tsy-119492	Tarsius syrichta	71.49	0.00e+00	1144.00
IUUC-Tni-120113	Tetraodon nigroviridis	62.76	0.00e+00	1039.00
IUUC-Tbe-127408	Tupaia belangeri	72.94	0.00e+00	695.00
IUUC-Ttr-128235	Tursiops truncatus	86.46	0.00e+00	919.00
IUUC-Vpa-130503	Vicugna pacos	78.37	0.00e+00	761.00
IUUC-Xtr-132859	Xenopus tropicalis	68.73	0.00e+00	1118.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence