iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	97.05	0.00e+00	1015.00	IUUC-Hsa-046462
E3 activity/RING/RING	43.08	3.00e-14	75.90	IUUC-Spo-108304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSGIGNKRAA GEPGTSVPPE KKTAVEDSGT TVETIKLGGV SSTEELDIRT LQSKNRKLAE 60
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLDQGLGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAAACAAAC AAACAAACAA AAATCGCATT CAATGCTTCG CGTTGAAGAG GTTGGTCACG 60
TTAGCTCTGA AGTCTGAATC AGTCTCCGCC CCACTCAAGC AACACAGAGG AGGCGGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR015422--PyrdxlP-dep_Trfase_sub2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0033503--C:HULC complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0003682--F:chromatin binding
GO:0003730--F:mRNA 3'-UTR binding
GO:0003713--F:transcription coactivator activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0030336--P:negative regulation of cell migration
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:0031062--P:positive regulation of histone methylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:313216

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000858	Aegilops tauschii	45.45	1.00e-09	57.00
IUUC-Aml-001976	Ailuropoda melanoleuca	95.86	0.00e+00	1029.00
IUUC-Apl-003407	Anas platyrhynchos	87.37	0.00e+00	945.00
IUUC-Aca-004246	Anolis carolinensis	87.34	0.00e+00	940.00
IUUC-Ago-007988	Ashbya gossypii	31.15	4.00e-15	76.30
IUUC-Acl-008319	Aspergillus clavatus	26.82	4.00e-14	73.20
IUUC-Aor-010142	Aspergillus oryzae	28.96	4.00e-15	77.00
IUUC-Ate-010547	Aspergillus terreus	26.54	1.00e-14	74.70
IUUC-Ame-011916	Astyanax mexicanus	77.93	2.00e-143	503.00
IUUC-Bgr-012245	Blumeria graminis	41.51	6.00e-10	59.70
IUUC-Bta-012357	Bos taurus	96.76	0.00e+00	1038.00
IUUC-Cja-019244	Callithrix jacchus	96.83	0.00e+00	1001.00
IUUC-Cfa-020320	Canis familiaris	97.05	0.00e+00	1018.00
IUUC-Cpo-021617	Cavia porcellus	94.26	0.00e+00	1638.00
IUUC-Csa-023509	Chlorocebus sabaeus	97.21	0.00e+00	1006.00
IUUC-Cho-024616	Choloepus hoffmanni	84.57	5.00e-145	508.00
IUUC-Cme-027134	Cyanidioschyzon merolae	39.06	1.00e-13	71.60
IUUC-Dno-029537	Dasypus novemcinctus	97.05	0.00e+00	1019.00
IUUC-Dor-030250	Dipodomys ordii	92.81	0.00e+00	974.00
IUUC-Dse-031300	Dothistroma septosporum	38.46	2.00e-15	77.40
IUUC-Ete-033164	Echinops telfairi	93.21	0.00e+00	1189.00
IUUC-Eca-033347	Equus caballus	96.59	0.00e+00	1038.00
IUUC-Eeu-034801	Erinaceus europaeus	94.58	3.00e-170	592.00
IUUC-Fca-036024	Felis catus	97.79	0.00e+00	1028.00
IUUC-Fal-037622	Ficedula albicollis	88.85	0.00e+00	952.00
IUUC-Gmo-039446	Gadus morhua	77.55	3.00e-132	466.00
IUUC-Ggr-040117	Gaeumannomyces graminis	45.28	2.00e-11	64.30
IUUC-Gga-040412	Gallus gallus	89.17	0.00e+00	904.00
IUUC-Gac-042205	Gasterosteus aculeatus	61.03	9.00e-143	501.00
IUUC-Ggo-044703	Gorilla gorilla	97.02	0.00e+00	1004.00
IUUC-Hsa-046462	Homo sapiens	97.21	0.00e+00	1006.00
IUUC-Itr-048298	Ictidomys tridecemlineatus	97.04	0.00e+00	1005.00
IUUC-Lch-049505	Latimeria chalumnae	74.24	0.00e+00	705.00
IUUC-Loc-051951	Lepisosteus oculatus	66.48	1.00e-111	397.00
IUUC-Lma-053312	Leptosphaeria maculans	28.71	6.00e-15	76.30
IUUC-Laf-054122	Loxodonta africana	96.22	0.00e+00	1017.00
IUUC-Mcc-054647	Macaca mulatta	97.21	0.00e+00	1006.00
IUUC-Meu-056559	Macropus eugenii	91.71	0.00e+00	1441.00
IUUC-Mpo-057568	Magnaporthe poae	45.28	2.00e-11	64.30
IUUC-Mga-059731	Meleagris gallopavo	65.84	6.00e-173	601.00
IUUC-Mmr-061495	Microcebus murinus	96.94	0.00e+00	1040.00
IUUC-Mdo-062599	Monodelphis domestica	93.17	0.00e+00	970.00
IUUC-Mmu-063278	Mus musculus	99.18	0.00e+00	1617.00
IUUC-Mpu-065910	Mustela putorius furo	96.22	0.00e+00	1033.00
IUUC-Mlu-067040	Myotis lucifugus	96.31	0.00e+00	1012.00
IUUC-Ncr-068695	Neurospora crassa	27.31	4.00e-12	67.00
IUUC-Nle-069058	Nomascus leucogenys	97.39	0.00e+00	1008.00
IUUC-Opr-071149	Ochotona princeps	96.69	0.00e+00	1008.00
IUUC-Ont-072543	Oreochromis niloticus	75.49	3.00e-134	473.00
IUUC-Oan-072996	Ornithorhynchus anatinus	97.20	0.00e+00	632.00
IUUC-Ocu-074773	Oryctolagus cuniculus	97.95	0.00e+00	1019.00
IUUC-Ola-087287	Oryzias latipes	76.69	4.00e-132	466.00
IUUC-Olu-087683	Ostreococcus lucimarinus	36.36	1.00e-13	68.60
IUUC-Oga-088961	Otolemur garnettii	96.94	0.00e+00	1039.00
IUUC-Oar-089755	Ovis aries	97.61	0.00e+00	1023.00
IUUC-Ptr-091602	Pan troglodytes	97.21	0.00e+00	1006.00
IUUC-Pan-092263	Papio anubis	97.21	0.00e+00	1006.00
IUUC-Psi-093554	Pelodiscus sinensis	88.85	0.00e+00	952.00
IUUC-Pab-098598	Pongo abelii	96.83	0.00e+00	1002.00
IUUC-Pca-100157	Procavia capensis	95.05	0.00e+00	988.00
IUUC-Pva-102720	Pteropus vampyrus	95.86	0.00e+00	1008.00
IUUC-Sha-107000	Sarcophilus harrisii	94.10	0.00e+00	956.00
IUUC-Sja-107993	Schizosaccharomyces japonicus	45.00	1.00e-12	68.20
IUUC-Spo-108304	Schizosaccharomyces pombe	43.08	8.00e-15	75.90
IUUC-Sar-113349	Sorex araneus	96.09	0.00e+00	937.00
IUUC-Ssc-115723	Sus scrofa	96.04	0.00e+00	1030.00
IUUC-Tgu-116549	Taeniopygia guttata	88.31	0.00e+00	879.00
IUUC-Tsy-118808	Tarsius syrichta	96.24	1.00e-178	620.00
IUUC-Tni-120790	Tetraodon nigroviridis	61.47	0.00e+00	940.00
IUUC-Ttr-128266	Tursiops truncatus	95.88	0.00e+00	1025.00
IUUC-Vpa-130237	Vicugna pacos	96.24	0.00e+00	1031.00
IUUC-Xtr-132589	Xenopus tropicalis	73.16	0.00e+00	1222.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence