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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106208
UUCD1 version UUC-SaC-00132
Ensembl Protein ID YOR269W
UniProt Accession P39946; D6W2W9; LIS1_YEAST
Genbank Protein ID AAB00685.1; CAA61775.1; CAA99493.1; DAA11035.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID U16827; X89633; Z75177; BK006948
Gene Name PAC1; LIS1; YOR269W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YOR269W YOR269W YOR269W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.20e-28 94.4 415 451
UBD/Beta-Prp 8.70e-42 141.7 156 492
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvllk 37
           gH ++v++++  + +l s++dD+++++WDl tg +l+
   Q: 415  GHLSWVRDISIRGQYLFSCADDKSVRCWDLNTGQCLH 451
           8**********558*********************97 PP
   

   UBD/Beta-Prp
   S: 11   svitcvkfspdksllatgsrdgtikvwdvttgkl.lrslsgheaevtavk.....fspdgk....ilvtgseDrtikvw.dls....tgkcvhtlkgheds 96
           s +t+vk +p+ ++++++ + g++  +d+++ +  l+sl++h++++t+++     + +++k    ++vt+s+D  i+v+        +++++++l ghe+ 
   Q: 156  SSVTSVKLHPNLPIVFVATDHGKLYAFDLFNYTIpLASLQSHTKAITSMDvlftnYTNSSKknylVIVTASKDLQIHVFkW-VseecKFQQIRSLLGHEHI 255
           67899*******************999999987789*********7766522111444444689999************62.334569999999******* PP
   S: 97   vlslsfsp..sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls...fdsng 192
           v ++++ +  ++ +++s s+d+t+++wd ++g+ l+ t+++h+++v+++ v +  ++++sGs D+t+rl   ++g+ l   tg h+ ++++++   f +++
   Q: 256  VSAVKIWQknNDVHIASCSRDQTVKIWDFHNGWSLK-TFQPHSQWVRSIDVLG--DYIISGSHDTTLRLTHWPSGNGLSVGTG-HEFPIEKVKfihFIEDS 352
           ******99866699**********************.***************9..**************999*********99.*********88844444 PP
   S: 193  ..................kelvsgsldgtvklwdlq.................tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllk 258
                             +++vs+s+d+t+k+w++                  + +cv tl+gh ++v+++     +++l s+++D+s+r+Wdl +g++l+
   Q: 353  peirfrtpstdryknwgmQYCVSASRDRTIKIWEIPlptlmahrapipnptdsNFRCVLTLKGHLSWVRDISIR--GQYLFSCADDKSVRCWDLNTGQCLH 451
           666777777888899999***********************9999999999999999************99999..************************* PP
   S: 259  tlqlhnssvisvav..lsfg.....dnvlvlgsedskvniw 292
           + ++ ++ ++ +    ++f+     ++++v+g+ d+k n++
   Q: 452  VWEKLHTGFVNCLDldVDFDsnvtpRQMMVTGGLDCKSNVF 492
           **99885554444436333366668888999999**99987 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8.
 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. Following plus end binding, dynein may be offloaded to the cortex by NUM1. Required for viability in the absence of the kinesin-related microtubule-dependent motor protein CIN8.
Protein Sequence
(Fasta)
MTNWQQQLPL TDTQKNELDK SVLRYLNWNY KQTVRHEHAQ DYESVRHAIV TLSGFLLQES 60
VDRQEFISNN DTSNESMVDI DELLLPKKWN SIVRLQKKII ELEQNTETLV SQIKDLNTQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106208|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGACTAACT GGCAGCAACA GCTTCCTTTA ACAGATACAC AGAAAAATGA ACTCGATAAA 60
AGTGTCCTCC GATATTTGAA TTGGAATTAC AAACAAACTG TACGACATGA GCATGCTCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106208|E3,WD_repeat;UBD,Beta-Prp|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005881--C:cytoplasmic microtubule
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0042802--F:identical protein binding
GO:0051010--F:microtubule plus-end binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0030473--P:nuclear migration along microtubule
GO:2000582--P:positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
GO:1903033--P:positive regulation of microtubule plus-end binding
KEGG sce:YOR269W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 29.77 1.00e-36 145.00
IUUC-Apl-004024 Anas platyrhynchos 27.72 4.00e-37 146.00
IUUC-Aca-004564 Anolis carolinensis 27.87 2.00e-37 147.00
IUUC-Ago-007862 Ashbya gossypii 44.59 8.00e-113 398.00
IUUC-Acl-008360 Aspergillus clavatus 27.29 1.00e-35 142.00
IUUC-Afl-008502 Aspergillus flavus 30.60 2.00e-40 157.00
IUUC-Afu-008848 Aspergillus fumigatus 26.90 4.00e-36 143.00
IUUC-Ani-009173 Aspergillus nidulans 26.13 3.00e-33 134.00
IUUC-Ang-009873 Aspergillus niger 26.17 4.00e-36 143.00
IUUC-Aor-009973 Aspergillus oryzae 27.93 4.00e-34 137.00
IUUC-Ate-010523 Aspergillus terreus 24.21 6.00e-32 129.00
IUUC-Ame-010969 Astyanax mexicanus 27.90 6.00e-37 146.00
IUUC-Bgr-011972 Blumeria graminis 26.34 2.00e-34 137.00
IUUC-Bta-013106 Bos taurus 27.29 4.00e-37 146.00
IUUC-Bci-013615 Botrytis cinerea 27.04 3.00e-36 144.00
IUUC-Cel-018459 Caenorhabditis elegans 26.65 2.00e-29 121.00
IUUC-Cja-018755 Callithrix jacchus 29.77 1.00e-36 145.00
IUUC-Cfa-020749 Canis familiaris 27.29 4.00e-37 146.00
IUUC-Cpo-022371 Cavia porcellus 27.29 4.00e-37 146.00
IUUC-Cin-025753 Ciona intestinalis 27.74 1.00e-35 141.00
IUUC-Csv-025817 Ciona savignyi 30.10 7.00e-35 139.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 28.50 2.00e-31 127.00
IUUC-Cne-027087 Cryptococcus neoformans 26.92 1.00e-32 132.00
IUUC-Dre-027554 Danio rerio 27.90 8.00e-37 145.00
IUUC-Dno-029050 Dasypus novemcinctus 27.51 3.00e-37 147.00
IUUC-Dse-031164 Dothistroma septosporum 30.20 1.00e-37 148.00
IUUC-Fca-036498 Felis catus 27.29 4.00e-37 146.00
IUUC-Fal-036920 Ficedula albicollis 27.72 4.00e-37 146.00
IUUC-Fox-037996 Fusarium oxysporum 27.27 2.00e-39 154.00
IUUC-Fso-038160 Fusarium solani 27.10 4.00e-36 143.00
IUUC-Gmo-039166 Gadus morhua 28.11 2.00e-38 151.00
IUUC-Ggr-040051 Gaeumannomyces graminis 28.57 6.00e-37 146.00
IUUC-Gga-040623 Gallus gallus 27.72 4.00e-37 146.00
IUUC-Gac-041363 Gasterosteus aculeatus 27.68 1.00e-37 148.00
IUUC-Hsa-046358 Homo sapiens 27.29 7.00e-37 145.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 27.29 4.00e-37 146.00
IUUC-Kpa-049351 Komagataella pastoris 29.42 3.00e-47 180.00
IUUC-Lch-049936 Latimeria chalumnae 27.53 4.00e-37 146.00
IUUC-Loc-052476 Lepisosteus oculatus 29.80 1.00e-36 145.00
IUUC-Lma-053170 Leptosphaeria maculans 29.85 8.00e-38 149.00
IUUC-Laf-053713 Loxodonta africana 29.77 7.00e-37 145.00
IUUC-Mcc-054628 Macaca mulatta 27.08 9.00e-37 145.00
IUUC-Mor-056962 Magnaporthe oryzae 27.67 2.00e-36 144.00
IUUC-Mpo-057583 Magnaporthe poae 28.32 3.00e-36 144.00
IUUC-Mla-058819 Melampsora laricipopulina 28.72 3.00e-36 144.00
IUUC-Mga-059945 Meleagris gallopavo 27.72 5.00e-37 146.00
IUUC-Mvi-060403 Microbotryum violaceum 30.85 1.00e-41 161.00
IUUC-Mmr-061289 Microcebus murinus 29.77 1.00e-36 145.00
IUUC-Mmu-063253 Mus musculus 27.29 4.00e-37 146.00
IUUC-Mpu-066638 Mustela putorius furo 27.29 4.00e-37 146.00
IUUC-Mlu-067267 Myotis lucifugus 28.73 5.00e-37 146.00
IUUC-Nfi-068571 Neosartorya fischeri 25.74 4.00e-28 117.00
IUUC-Ncr-068895 Neurospora crassa 27.91 1.00e-36 145.00
IUUC-Opr-070579 Ochotona princeps 27.51 3.00e-37 147.00
IUUC-Ont-071905 Oreochromis niloticus 27.93 2.00e-38 151.00
IUUC-Oan-073072 Ornithorhynchus anatinus 27.29 4.00e-37 146.00
IUUC-Ocu-074180 Oryctolagus cuniculus 27.51 3.00e-37 147.00
IUUC-Ola-086772 Oryzias latipes 28.51 2.00e-38 150.00
IUUC-Oar-090394 Ovis aries 27.29 4.00e-37 146.00
IUUC-Ptr-091517 Pan troglodytes 27.29 4.00e-37 146.00
IUUC-Pan-092421 Papio anubis 27.08 9.00e-37 145.00
IUUC-Psi-093370 Pelodiscus sinensis 27.29 1.00e-36 144.00
IUUC-Pno-094815 Phaeosphaeria nodorum 28.69 7.00e-40 155.00
IUUC-Pfo-096228 Poecilia formosa 27.47 2.00e-37 147.00
IUUC-Pab-098421 Pongo abelii 27.29 4.00e-37 146.00
IUUC-Pva-102960 Pteropus vampyrus 27.29 2.00e-37 147.00
IUUC-Pgr-103538 Puccinia graminis 26.12 6.00e-35 139.00
IUUC-Pte-104261 Pyrenophora teres 29.11 1.00e-39 155.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 29.11 1.00e-39 155.00
IUUC-Rno-105123 Rattus norvegicus 27.29 4.00e-37 146.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 27.04 6.00e-37 146.00
IUUC-Sre-115003 Sporisorium reilianum 29.39 3.00e-38 150.00
IUUC-Ssc-116148 Sus scrofa 27.29 4.00e-37 146.00
IUUC-Tgu-117299 Taeniopygia guttata 27.72 4.00e-37 146.00
IUUC-Tru-118179 Takifugu rubripes 27.29 1.00e-36 145.00
IUUC-Tsy-119493 Tarsius syrichta 27.33 2.00e-36 144.00
IUUC-Tni-120355 Tetraodon nigroviridis 28.11 4.00e-36 143.00
IUUC-Tre-121977 Trichoderma reesei 29.02 1.00e-35 142.00
IUUC-Tvi-122661 Trichoderma virens 28.23 4.00e-36 143.00
IUUC-Tme-127031 Tuber melanosporum 25.54 2.00e-35 141.00
IUUC-Ttr-128929 Tursiops truncatus 27.29 5.00e-37 146.00
IUUC-Uma-129347 Ustilago maydis 29.26 3.00e-38 150.00
IUUC-Vda-129837 Verticillium dahliae 28.15 1.00e-35 142.00
IUUC-Xtr-131985 Xenopus tropicalis 27.45 9.00e-38 149.00
IUUC-Xma-133469 Xiphophorus maculatus 27.68 1.00e-37 148.00
IUUC-Yli-134403 Yarrowia lipolytica 27.97 1.00e-38 152.00
Created Date 25-Jun-2017

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