iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003449

Ensembl Protein ID

ENSAPLP00000009703.1

UniProt Accession

U3IR30; U3IR30_ANAPL

Genbank Protein ID

ENSAPLP00000009703

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01108101

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000009963.1	ENSAPLT00000010400.1	ENSAPLP00000009703.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.30e-56	183.4	452	486
UBD/Beta-Prp	2.10e-66	223.9	366	530

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 452  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 486
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 366  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 449
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 450  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 530
           **************9..***********************************99.************..99**************7 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

VTLQCSVPRS LWLGCSNLVE SMCALRCLQS MPSVRCLQNT SVMEDQNEDE SPKKNTLWQI 60
SNGTSSVIVS RKRPSEGNYE KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACCCTGC AGTGTTCTGT GCCAAGGTCT TTGTGGCTAG GCTGCTCCAA CCTGGTAGAG 60
AGCATGTGCG CACTGAGATG CCTGCAGAGC ATGCCCAGTG TCAGATGTCT CCAGGTGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	94.76	0.00e+00	1068.00
IUUC-Ame-011174	Astyanax mexicanus	86.51	0.00e+00	994.00
IUUC-Bta-012920	Bos taurus	98.28	0.00e+00	1055.00
IUUC-Cel-018392	Caenorhabditis elegans	63.23	0.00e+00	634.00
IUUC-Cja-018879	Callithrix jacchus	94.76	0.00e+00	1068.00
IUUC-Cfa-020021	Canis familiaris	94.76	0.00e+00	1068.00
IUUC-Cpo-022151	Cavia porcellus	99.03	0.00e+00	1048.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.41	0.00e+00	1048.00
IUUC-Cho-024658	Choloepus hoffmanni	89.74	9.00e-143	499.00
IUUC-Dre-028160	Danio rerio	90.40	0.00e+00	963.00
IUUC-Dor-030498	Dipodomys ordii	94.72	0.00e+00	1058.00
IUUC-Eca-033804	Equus caballus	95.41	0.00e+00	1016.00
IUUC-Fca-035887	Felis catus	99.23	0.00e+00	1058.00
IUUC-Fal-036783	Ficedula albicollis	99.81	0.00e+00	1094.00
IUUC-Gmo-038590	Gadus morhua	85.35	0.00e+00	954.00
IUUC-Gga-040628	Gallus gallus	99.44	0.00e+00	1089.00
IUUC-Gac-041305	Gasterosteus aculeatus	86.26	0.00e+00	974.00
IUUC-Ggo-044604	Gorilla gorilla	94.76	0.00e+00	1068.00
IUUC-Hsa-046139	Homo sapiens	94.76	0.00e+00	1068.00
IUUC-Lch-050460	Latimeria chalumnae	97.09	0.00e+00	1033.00
IUUC-Laf-053968	Loxodonta africana	98.55	0.00e+00	1125.00
IUUC-Mcc-055822	Macaca mulatta	95.74	0.00e+00	1102.00
IUUC-Mga-059225	Meleagris gallopavo	99.61	0.00e+00	1058.00
IUUC-Mmr-060746	Microcebus murinus	94.76	0.00e+00	1068.00
IUUC-Mdo-062005	Monodelphis domestica	99.22	0.00e+00	1048.00
IUUC-Mmu-063851	Mus musculus	97.83	0.00e+00	1118.00
IUUC-Mpu-065716	Mustela putorius furo	98.65	0.00e+00	1053.00
IUUC-Mlu-067001	Myotis lucifugus	99.41	0.00e+00	1048.00
IUUC-Ncr-068639	Neurospora crassa	37.36	9.00e-45	175.00
IUUC-Nle-069788	Nomascus leucogenys	95.94	0.00e+00	1013.00
IUUC-Opr-071229	Ochotona princeps	94.58	0.00e+00	1066.00
IUUC-Ont-071792	Oreochromis niloticus	86.98	0.00e+00	984.00
IUUC-Oan-072782	Ornithorhynchus anatinus	99.81	0.00e+00	1094.00
IUUC-Ocu-074894	Oryctolagus cuniculus	98.55	0.00e+00	1125.00
IUUC-Ola-086985	Oryzias latipes	89.03	0.00e+00	1013.00
IUUC-Oga-088604	Otolemur garnettii	89.66	0.00e+00	1045.00
IUUC-Oar-090412	Ovis aries	99.25	0.00e+00	1089.00
IUUC-Ptr-091039	Pan troglodytes	94.58	0.00e+00	1067.00
IUUC-Pan-092770	Papio anubis	98.49	0.00e+00	1077.00
IUUC-Psi-093887	Pelodiscus sinensis	98.91	0.00e+00	1123.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.44	5.00e-44	172.00
IUUC-Pfo-096783	Poecilia formosa	89.21	0.00e+00	1014.00
IUUC-Pva-102547	Pteropus vampyrus	94.58	0.00e+00	1062.00
IUUC-Rno-105246	Rattus norvegicus	98.50	0.00e+00	1083.00
IUUC-Sha-107339	Sarcophilus harrisii	99.22	0.00e+00	1048.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.21	4.00e-66	244.00
IUUC-Tgu-116541	Taeniopygia guttata	99.64	0.00e+00	1132.00
IUUC-Tru-117671	Takifugu rubripes	88.31	0.00e+00	1005.00
IUUC-Tni-120359	Tetraodon nigroviridis	89.98	0.00e+00	952.00
IUUC-Tbe-127418	Tupaia belangeri	89.25	0.00e+00	980.00
IUUC-Ttr-129131	Tursiops truncatus	94.76	0.00e+00	1069.00
IUUC-Vpa-130668	Vicugna pacos	94.58	0.00e+00	1066.00
IUUC-Xma-133187	Xiphophorus maculatus	95.37	1.00e-157	547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence