iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053968

UUCD1 version

UUC-LoA-00230

Ensembl Protein ID

ENSLAFP00000005429.3

UniProt Accession

G3SY84; G3SY84_LOXAF

Protein Name

Uncharacterized protein

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006465.3	ENSLAFT00000026754.1	ENSLAFP00000024399.1
ENSLAFG00000006465.3	ENSLAFT00000006467.3	ENSLAFP00000005429.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-58	190.5	462	496
UBD/Beta-Prp	1.20e-68	231.9	375	540

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 462  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 496
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 375  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 458
           4555679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 459  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 540
           ***************9..***********************************99.************..99**************7 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQN TSVMEDQNED 60
ESPKKNTLWQ ISNGTSSVIV SRKRPSEGNY QKEKDLCIKY FDQWSESDQV EFVEHLISRM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCCG ACTCGGTAAT TGAGGACAAG ACCATCGAGC TCATGGTGAG TGCGGCCCGC 60
TGGACCGACC GTTCTTCCGT CCGTCCGGCT CCAGGGCGGT CCTGCCCACC TCAACGTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	96.27	0.00e+00	1108.00
IUUC-Apl-003449	Anas platyrhynchos	98.55	0.00e+00	1125.00
IUUC-Ame-011174	Astyanax mexicanus	86.22	0.00e+00	1013.00
IUUC-Bta-012920	Bos taurus	98.85	0.00e+00	1065.00
IUUC-Cja-018879	Callithrix jacchus	96.27	0.00e+00	1108.00
IUUC-Cfa-020021	Canis familiaris	96.27	0.00e+00	1108.00
IUUC-Cpo-022151	Cavia porcellus	99.61	0.00e+00	1057.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1057.00
IUUC-Cho-024658	Choloepus hoffmanni	92.25	3.00e-152	531.00
IUUC-Cin-025188	Ciona intestinalis	80.42	0.00e+00	824.00
IUUC-Dre-028160	Danio rerio	90.19	0.00e+00	964.00
IUUC-Dno-029485	Dasypus novemcinctus	89.38	0.00e+00	932.00
IUUC-Dor-030498	Dipodomys ordii	95.62	0.00e+00	1071.00
IUUC-Dse-031287	Dothistroma septosporum	29.14	1.00e-52	201.00
IUUC-Eca-033804	Equus caballus	95.98	0.00e+00	1025.00
IUUC-Fca-035887	Felis catus	93.96	0.00e+00	1077.00
IUUC-Fal-036783	Ficedula albicollis	99.44	0.00e+00	1093.00
IUUC-Gmo-038590	Gadus morhua	84.90	0.00e+00	968.00
IUUC-Gga-040628	Gallus gallus	99.06	0.00e+00	1089.00
IUUC-Gac-041305	Gasterosteus aculeatus	85.44	0.00e+00	986.00
IUUC-Ggo-044604	Gorilla gorilla	96.27	0.00e+00	1108.00
IUUC-Hsa-046139	Homo sapiens	96.27	0.00e+00	1108.00
IUUC-Lch-050460	Latimeria chalumnae	96.89	0.00e+00	1035.00
IUUC-Mcc-055822	Macaca mulatta	95.26	0.00e+00	1117.00
IUUC-Mga-059225	Meleagris gallopavo	99.03	0.00e+00	1050.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	1.00e-69	258.00
IUUC-Mmr-060746	Microcebus murinus	96.27	0.00e+00	1108.00
IUUC-Mdo-062005	Monodelphis domestica	99.41	0.00e+00	1052.00
IUUC-Mmu-063851	Mus musculus	99.29	0.00e+00	1158.00
IUUC-Mpu-065716	Mustela putorius furo	99.22	0.00e+00	1061.00
IUUC-Mlu-067001	Myotis lucifugus	100.00	0.00e+00	1057.00
IUUC-Nle-069788	Nomascus leucogenys	96.51	0.00e+00	1021.00
IUUC-Opr-071229	Ochotona princeps	96.09	0.00e+00	1107.00
IUUC-Ont-071792	Oreochromis niloticus	86.36	0.00e+00	991.00
IUUC-Oan-072782	Ornithorhynchus anatinus	99.44	0.00e+00	1093.00
IUUC-Ocu-074894	Oryctolagus cuniculus	100.00	0.00e+00	1164.00
IUUC-Ola-086985	Oryzias latipes	88.16	0.00e+00	1026.00
IUUC-Oga-088604	Otolemur garnettii	90.33	0.00e+00	1056.00
IUUC-Oar-090412	Ovis aries	100.00	0.00e+00	1100.00
IUUC-Ptr-091039	Pan troglodytes	96.09	0.00e+00	1107.00
IUUC-Pan-092770	Papio anubis	100.00	0.00e+00	1117.00
IUUC-Psi-093887	Pelodiscus sinensis	98.00	0.00e+00	1119.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	1.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	88.34	0.00e+00	1027.00
IUUC-Pva-102547	Pteropus vampyrus	96.07	0.00e+00	1093.00
IUUC-Rno-105246	Rattus norvegicus	99.25	0.00e+00	1093.00
IUUC-Sha-107339	Sarcophilus harrisii	99.41	0.00e+00	1052.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.48	3.00e-74	272.00
IUUC-Spo-108200	Schizosaccharomyces pombe	31.92	2.00e-66	246.00
IUUC-Tgu-116541	Taeniopygia guttata	98.55	0.00e+00	1125.00
IUUC-Tru-117671	Takifugu rubripes	87.63	0.00e+00	1019.00
IUUC-Tni-120359	Tetraodon nigroviridis	89.77	0.00e+00	952.00
IUUC-Tbe-127418	Tupaia belangeri	90.15	0.00e+00	994.00
IUUC-Ttr-129131	Tursiops truncatus	96.27	0.00e+00	1110.00
IUUC-Vpa-130668	Vicugna pacos	95.89	0.00e+00	1096.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	5.00e-158	549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence