iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088444

Ensembl Protein ID

ENSOGAP00000015661.1

UniProt Accession

H0XHS1; H0XHS1_OTOGA

Genbank Protein ID

ENSOGAP00000015661

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03116545

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000028052.1	ENSOGAT00000026523.1	ENSOGAP00000015661.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-18	65.6	658	709

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 658  ARYNFAARDMRELSLREGDVVRIYSRVGGDQGWWKG--ETSGRIGWFPSTYVEE 709
           67**********************************..9*************86 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

RPFPSEETTE NDDDVYRSLE ELADEHDLGE DIYDCVPCED GGDDIYEDII KVEVQQPMKM 60
GMTEDDKRNC CLLEIQETEA KYYRTLEDIE KNYMSPLRLV LSPADMAAVF INLEDLIRVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCTTTTC CTTCAGAGGA GACCACGGAG AATGACGATG ACGTCTACCG CAGCCTGGAG 60
GAGCTGGCCG AGTGAGTCGG GGGGGGGCAG GGAAGAAAGG AGGGGGAGAA GTTCCTCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	89.36	0.00e+00	1280.00
IUUC-Apl-003262	Anas platyrhynchos	86.39	0.00e+00	1267.00
IUUC-Aca-004628	Anolis carolinensis	66.44	0.00e+00	887.00
IUUC-Ath-007352	Arabidopsis thaliana	41.18	5.00e-04	39.70
IUUC-Ame-011608	Astyanax mexicanus	79.50	0.00e+00	1191.00
IUUC-Bta-013147	Bos taurus	90.54	0.00e+00	1297.00
IUUC-Cel-018578	Caenorhabditis elegans	27.00	4.00e-72	266.00
IUUC-Cja-018877	Callithrix jacchus	87.25	0.00e+00	1229.00
IUUC-Cfa-020315	Canis familiaris	96.34	0.00e+00	1280.00
IUUC-Cpo-021543	Cavia porcellus	88.32	0.00e+00	1282.00
IUUC-Csa-024204	Chlorocebus sabaeus	88.96	0.00e+00	1299.00
IUUC-Dre-028308	Danio rerio	75.53	0.00e+00	1141.00
IUUC-Dno-029584	Dasypus novemcinctus	91.74	0.00e+00	1169.00
IUUC-Dor-031014	Dipodomys ordii	80.63	0.00e+00	1101.00
IUUC-Eca-033448	Equus caballus	86.84	0.00e+00	1269.00
IUUC-Eeu-035182	Erinaceus europaeus	84.26	5.00e-166	578.00
IUUC-Fca-035460	Felis catus	91.90	0.00e+00	1342.00
IUUC-Fal-036684	Ficedula albicollis	84.33	0.00e+00	1254.00
IUUC-Gmo-038816	Gadus morhua	78.03	0.00e+00	1109.00
IUUC-Gga-040999	Gallus gallus	90.32	0.00e+00	1293.00
IUUC-Gac-041353	Gasterosteus aculeatus	79.27	0.00e+00	1146.00
IUUC-Ggo-044558	Gorilla gorilla	91.09	0.00e+00	1306.00
IUUC-Hsa-046208	Homo sapiens	91.09	0.00e+00	1307.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	88.04	0.00e+00	1185.00
IUUC-Lch-049650	Latimeria chalumnae	53.18	7.00e-67	246.00
IUUC-Loc-052827	Lepisosteus oculatus	75.50	0.00e+00	1157.00
IUUC-Laf-054009	Loxodonta africana	85.56	0.00e+00	1246.00
IUUC-Mcc-055054	Macaca mulatta	91.09	0.00e+00	1307.00
IUUC-Meu-056269	Macropus eugenii	78.12	0.00e+00	706.00
IUUC-Mla-059044	Melampsora laricipopulina	25.19	5.00e-19	90.50
IUUC-Mga-060106	Meleagris gallopavo	86.52	0.00e+00	1264.00
IUUC-Mmr-061118	Microcebus murinus	90.84	0.00e+00	1310.00
IUUC-Mdo-062380	Monodelphis domestica	91.11	0.00e+00	1306.00
IUUC-Mmu-063135	Mus musculus	90.30	0.00e+00	1325.00
IUUC-Mpu-066135	Mustela putorius furo	94.11	0.00e+00	1346.00
IUUC-Nle-069465	Nomascus leucogenys	83.27	0.00e+00	1174.00
IUUC-Ont-071945	Oreochromis niloticus	76.17	0.00e+00	1122.00
IUUC-Oan-073384	Ornithorhynchus anatinus	84.23	0.00e+00	1171.00
IUUC-Ola-087499	Oryzias latipes	79.57	0.00e+00	1110.00
IUUC-Oar-089576	Ovis aries	86.80	0.00e+00	1221.00
IUUC-Ptr-090507	Pan troglodytes	92.32	0.00e+00	1315.00
IUUC-Pan-092325	Papio anubis	96.21	0.00e+00	1332.00
IUUC-Psi-094021	Pelodiscus sinensis	90.59	0.00e+00	1285.00
IUUC-Pma-094372	Petromyzon marinus	51.88	0.00e+00	691.00
IUUC-Pfo-096732	Poecilia formosa	76.06	0.00e+00	1130.00
IUUC-Pab-098426	Pongo abelii	80.73	0.00e+00	1062.00
IUUC-Pca-100295	Procavia capensis	88.90	0.00e+00	1312.00
IUUC-Rno-105332	Rattus norvegicus	89.22	0.00e+00	1249.00
IUUC-Sha-106529	Sarcophilus harrisii	88.13	0.00e+00	1218.00
IUUC-Ssc-116176	Sus scrofa	89.68	0.00e+00	1299.00
IUUC-Tgu-116917	Taeniopygia guttata	86.39	0.00e+00	1263.00
IUUC-Tru-118398	Takifugu rubripes	75.12	0.00e+00	957.00
IUUC-Tni-120819	Tetraodon nigroviridis	76.54	0.00e+00	1146.00
IUUC-Xtr-132747	Xenopus tropicalis	79.28	0.00e+00	1132.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence