iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054499

Ensembl Protein ID

ENSLAFP00000009603.3

UniProt Accession

G3T7L2; G3T7L2_LOXAF

Protein Name

Tyrosine-protein kinase

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011490.3	ENSLAFT00000011494.3	ENSLAFP00000009603.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-19	68.7	62	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 62   QDNLVIALHNYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 120
           6899**************************...**************************987 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DSKAMLPMRN GSDVRDPLVT YEGSIPPASP 60
LQDNLVIALH NYEPSHDGDL GFEKGEQLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGCA GCTGCAGCTC GAATCCTGAA GATGACTGGA TGGAAAACAT TGATGTGTGT 60
GAGAACTGCC ATTACCCCAT AGTCCCACTG GATAGCAAAG CCATGGTAAG AGGCAAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	93.88	0.00e+00	1037.00
IUUC-Apl-004134	Anas platyrhynchos	75.37	0.00e+00	719.00
IUUC-Bta-013264	Bos taurus	90.17	0.00e+00	1006.00
IUUC-Cja-019574	Callithrix jacchus	90.03	0.00e+00	692.00
IUUC-Cfa-021161	Canis familiaris	93.51	0.00e+00	1026.00
IUUC-Cpo-022492	Cavia porcellus	90.54	0.00e+00	1003.00
IUUC-Csa-023270	Chlorocebus sabaeus	73.81	0.00e+00	783.00
IUUC-Dre-028005	Danio rerio	70.29	0.00e+00	698.00
IUUC-Dno-029365	Dasypus novemcinctus	88.68	0.00e+00	978.00
IUUC-Dor-030892	Dipodomys ordii	92.28	0.00e+00	950.00
IUUC-Eca-033325	Equus caballus	89.81	0.00e+00	985.00
IUUC-Eeu-035004	Erinaceus europaeus	86.83	0.00e+00	794.00
IUUC-Fca-035908	Felis catus	92.58	0.00e+00	1030.00
IUUC-Fal-036804	Ficedula albicollis	66.73	0.00e+00	708.00
IUUC-Gmo-038984	Gadus morhua	61.21	0.00e+00	684.00
IUUC-Gga-040997	Gallus gallus	77.55	0.00e+00	883.00
IUUC-Gac-041854	Gasterosteus aculeatus	65.19	0.00e+00	715.00
IUUC-Ggo-045238	Gorilla gorilla	93.32	0.00e+00	1031.00
IUUC-Hsa-047039	Homo sapiens	91.65	0.00e+00	1017.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	91.28	0.00e+00	1013.00
IUUC-Lch-049568	Latimeria chalumnae	73.30	0.00e+00	832.00
IUUC-Mcc-054872	Macaca mulatta	72.86	0.00e+00	832.00
IUUC-Meu-056879	Macropus eugenii	87.38	0.00e+00	974.00
IUUC-Mga-059971	Meleagris gallopavo	76.99	0.00e+00	874.00
IUUC-Mmr-060740	Microcebus murinus	91.65	0.00e+00	1021.00
IUUC-Mdo-062192	Monodelphis domestica	87.57	0.00e+00	981.00
IUUC-Mmu-064241	Mus musculus	90.91	0.00e+00	1016.00
IUUC-Mpu-066595	Mustela putorius furo	91.28	0.00e+00	1016.00
IUUC-Mlu-067069	Myotis lucifugus	90.00	0.00e+00	1002.00
IUUC-Opr-070472	Ochotona princeps	93.14	0.00e+00	1029.00
IUUC-Ont-071711	Oreochromis niloticus	64.63	0.00e+00	686.00
IUUC-Ocu-074221	Oryctolagus cuniculus	91.11	0.00e+00	1011.00
IUUC-Ola-087000	Oryzias latipes	64.87	0.00e+00	712.00
IUUC-Oga-088225	Otolemur garnettii	91.47	0.00e+00	1018.00
IUUC-Oar-090244	Ovis aries	80.31	0.00e+00	944.00
IUUC-Ptr-090751	Pan troglodytes	91.03	0.00e+00	706.00
IUUC-Pan-091804	Papio anubis	90.72	0.00e+00	1003.00
IUUC-Psi-093252	Pelodiscus sinensis	70.96	0.00e+00	784.00
IUUC-Pfo-096542	Poecilia formosa	64.17	0.00e+00	715.00
IUUC-Pab-098168	Pongo abelii	91.10	0.00e+00	964.00
IUUC-Pca-100547	Procavia capensis	95.64	0.00e+00	647.00
IUUC-Rno-105542	Rattus norvegicus	90.54	0.00e+00	1015.00
IUUC-Sha-107524	Sarcophilus harrisii	87.38	0.00e+00	983.00
IUUC-Sar-113235	Sorex araneus	90.25	0.00e+00	869.00
IUUC-Ssc-115624	Sus scrofa	90.72	0.00e+00	1010.00
IUUC-Tru-118559	Takifugu rubripes	63.55	0.00e+00	712.00
IUUC-Ttr-129002	Tursiops truncatus	88.50	0.00e+00	966.00
IUUC-Xtr-132224	Xenopus tropicalis	71.80	0.00e+00	816.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence