iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019136.5	ENSBTAT00000025473.5	ENSBTAP00000025473.5
ENSBTAG00000019136.5	ENSBTAT00000057514.2	ENSBTAP00000051216.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.00e-26	92.9	226	299

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
           ++p+++++ Is+elMr+P+++psGitydr+ Ie++l++ g+ +Pvtr+plt+e+l+Pnl+++++i+a+++en++
   Q: 226  DIPDYLCGKISFELMREPCITPSGITYDRKDIEEHLQRVGHFDPVTRSPLTQEQLIPNLAMKEVIDAFISENGW 299
           69********************************************************************9986 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MKGKEEKEGG ARLGAGGASP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA 60
VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGAGCGC TGGACCGGGC CCGAGCGGAT CGCGGGCTCG GGCTGCGGGC GCAGGGCGGG 60
CTGGGCGCGG AGCCTGGGAG CGGAGCCCAG GCGGTGCCGC GCGGCGCCAT GAAGGGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat

Interpro

IPR023114--Elongated_TPR_rpt_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50005--TPR
PS50293--TPR_REGION
PS51698--U_BOX

Pfam

PF04564--U-box

SMART

SM00028--TPR
SM00504--Ubox

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0042405--C:nuclear inclusion body
GO:0005654--C:nucleoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0030018--C:Z disc
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0071218--P:cellular response to misfolded protein
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0032091--P:negative regulation of protein binding
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0090035--P:positive regulation of chaperone-mediated protein complex assembly
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031943--P:regulation of glucocorticoid metabolic process
GO:0031647--P:regulation of protein stability
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000537	Aegilops tauschii	36.90	1.00e-38	152.00
IUUC-Aml-001350	Ailuropoda melanoleuca	99.19	9.00e-147	512.00
IUUC-Atr-003168	Amborella trichopoda	33.64	9.00e-31	126.00
IUUC-Apl-003736	Anas platyrhynchos	88.76	1.00e-131	461.00
IUUC-Aca-004751	Anolis carolinensis	86.17	3.00e-142	497.00
IUUC-Aly-006292	Arabidopsis lyrata	34.88	9.00e-45	173.00
IUUC-Ath-007012	Arabidopsis thaliana	34.52	6.00e-43	167.00
IUUC-Acl-008025	Aspergillus clavatus	32.01	3.00e-36	145.00
IUUC-Afl-008721	Aspergillus flavus	31.82	1.00e-32	133.00
IUUC-Afu-008853	Aspergillus fumigatus	32.98	2.00e-35	142.00
IUUC-Ani-009349	Aspergillus nidulans	31.38	2.00e-34	139.00
IUUC-Ang-009674	Aspergillus niger	33.45	4.00e-32	131.00
IUUC-Aor-010014	Aspergillus oryzae	30.27	3.00e-27	115.00
IUUC-Ate-010467	Aspergillus terreus	29.76	1.00e-26	113.00
IUUC-Ame-011215	Astyanax mexicanus	60.90	2.00e-92	332.00
IUUC-Bgr-011971	Blumeria graminis	30.94	5.00e-25	107.00
IUUC-Bci-013945	Botrytis cinerea	41.03	1.00e-14	73.60
IUUC-Bdi-014483	Brachypodium distachyon	38.41	2.00e-45	175.00
IUUC-Bol-015676	Brassica oleracea	35.34	3.00e-46	179.00
IUUC-Bra-017897	Brassica rapa	32.06	2.00e-29	122.00
IUUC-Cel-018323	Caenorhabditis elegans	40.79	8.00e-55	206.00
IUUC-Cja-019657	Callithrix jacchus	96.47	2.00e-165	574.00
IUUC-Cfa-020470	Canis familiaris	98.69	2.00e-134	471.00
IUUC-Cpo-022033	Cavia porcellus	96.35	9.00e-169	585.00
IUUC-Cre-022896	Chlamydomonas reinhardtii	28.12	7.00e-29	120.00
IUUC-Csa-023038	Chlorocebus sabaeus	97.53	1.00e-158	552.00
IUUC-Cin-025381	Ciona intestinalis	52.69	1.00e-86	312.00
IUUC-Cgl-026524	Colletotrichum gloeosporioides	32.61	7.00e-39	154.00
IUUC-Dre-027610	Danio rerio	80.21	3.00e-136	477.00
IUUC-Dno-030087	Dasypus novemcinctus	96.68	6.00e-169	586.00
IUUC-Dor-031029	Dipodomys ordii	91.17	1.00e-148	518.00
IUUC-Dse-031275	Dothistroma septosporum	31.83	9.00e-28	117.00
IUUC-Dme-031856	Drosophila melanogaster	57.82	2.00e-93	335.00
IUUC-Ete-033087	Echinops telfairi	94.12	8.00e-141	492.00
IUUC-Eca-033512	Equus caballus	97.98	1.00e-145	508.00
IUUC-Eeu-034763	Erinaceus europaeus	93.48	2.00e-99	354.00
IUUC-Fca-036460	Felis catus	99.63	4.00e-161	560.00
IUUC-Fal-037441	Ficedula albicollis	89.08	6.00e-150	523.00
IUUC-Fox-038028	Fusarium oxysporum	30.69	3.00e-37	148.00
IUUC-Fso-038323	Fusarium solani	32.26	2.00e-28	119.00
IUUC-Gmo-038511	Gadus morhua	77.74	2.00e-131	461.00
IUUC-Ggr-039964	Gaeumannomyces graminis	33.68	2.00e-27	115.00
IUUC-Gga-040854	Gallus gallus	89.08	4.00e-149	520.00
IUUC-Gac-042175	Gasterosteus aculeatus	77.39	9.00e-128	449.00
IUUC-Gma-044046	Glycine max	36.10	4.00e-43	167.00
IUUC-Ggo-044512	Gorilla gorilla	97.53	1.00e-158	552.00
IUUC-Hsa-046872	Homo sapiens	97.53	1.00e-158	552.00
IUUC-Hvu-047661	Hordeum vulgare	35.66	2.00e-39	155.00
IUUC-Itr-048871	Ictidomys tridecemlineatus	96.47	2.00e-164	571.00
IUUC-Lch-049988	Latimeria chalumnae	79.93	3.00e-132	464.00
IUUC-Lpe-050693	Leersia perrieri	35.14	4.00e-43	167.00
IUUC-Loc-052195	Lepisosteus oculatus	79.05	2.00e-115	408.00
IUUC-Lma-053207	Leptosphaeria maculans	30.16	4.00e-29	123.00
IUUC-Laf-054584	Loxodonta africana	95.68	4.00e-168	583.00
IUUC-Mcc-054689	Macaca mulatta	97.53	1.00e-158	552.00
IUUC-Meu-055998	Macropus eugenii	89.83	3.00e-85	308.00
IUUC-Mor-057116	Magnaporthe oryzae	33.69	3.00e-39	155.00
IUUC-Mtr-057684	Medicago truncatula	33.58	2.00e-38	152.00
IUUC-Mga-059332	Meleagris gallopavo	89.16	3.00e-131	460.00
IUUC-Mmr-061377	Microcebus murinus	96.82	3.00e-157	547.00
IUUC-Mdo-061963	Monodelphis domestica	92.25	4.00e-147	513.00
IUUC-Mmu-063146	Mus musculus	96.03	4.00e-158	550.00
IUUC-Mac-064932	Musa acuminata	34.47	3.00e-28	118.00
IUUC-Mpu-066418	Mustela putorius furo	99.29	3.00e-168	583.00
IUUC-Mlu-067066	Myotis lucifugus	98.01	2.00e-177	614.00
IUUC-Nfi-068601	Neosartorya fischeri	32.98	3.00e-35	142.00
IUUC-Ncr-068761	Neurospora crassa	41.98	3.00e-16	79.00
IUUC-Nle-069374	Nomascus leucogenys	97.53	1.00e-158	552.00
IUUC-Opr-070765	Ochotona princeps	90.06	7.00e-99	352.00
IUUC-Ont-071996	Oreochromis niloticus	80.57	3.00e-130	457.00
IUUC-Oba-075967	Oryza barthii	36.10	3.00e-44	171.00
IUUC-Obr-076440	Oryza brachyantha	34.98	1.00e-31	132.00
IUUC-Ogl-077495	Oryza glaberrima	36.10	3.00e-44	171.00
IUUC-Ogu-078247	Oryza glumaepatula	36.07	2.00e-40	159.00
IUUC-Oin-079376	Oryza indica	36.10	3.00e-44	171.00
IUUC-Olo-081083	Oryza longistaminata	31.52	2.00e-31	129.00
IUUC-Ome-081935	Oryza meridionalis	29.06	3.00e-21	98.20
IUUC-Oni-082535	Oryza nivara	36.07	2.00e-40	159.00
IUUC-Opu-083794	Oryza punctata	36.10	1.00e-43	170.00
IUUC-Oru-085153	Oryza rufipogon	36.10	7.00e-44	170.00
IUUC-Osa-085936	Oryza sativa	35.51	9.00e-17	79.70
IUUC-Ola-087081	Oryzias latipes	78.80	9.00e-134	469.00
IUUC-Olu-087790	Ostreococcus lucimarinus	31.90	5.00e-32	130.00
IUUC-Oga-088331	Otolemur garnettii	96.35	8.00e-162	562.00
IUUC-Oar-089987	Ovis aries	96.06	4.00e-142	497.00
IUUC-Ptr-090855	Pan troglodytes	97.53	1.00e-158	552.00
IUUC-Pan-092801	Papio anubis	91.87	2.00e-156	545.00
IUUC-Psi-093393	Pelodiscus sinensis	87.95	1.00e-130	459.00
IUUC-Pma-094680	Petromyzon marinus	67.99	1.00e-110	392.00
IUUC-Pno-094913	Phaeosphaeria nodorum	33.22	1.00e-34	139.00
IUUC-Ppa-095976	Physcomitrella patens	34.17	6.00e-44	171.00
IUUC-Pfo-096850	Poecilia formosa	78.45	7.00e-127	446.00
IUUC-Pab-097963	Pongo abelii	97.53	1.00e-158	552.00
IUUC-Pop-098805	Populus trichocarpa	43.88	1.00e-24	106.00
IUUC-Pca-100788	Procavia capensis	96.68	3.00e-170	590.00
IUUC-Ppe-101221	Prunus persica	34.17	5.00e-44	171.00
IUUC-Pva-103076	Pteropus vampyrus	97.34	1.00e-170	592.00
IUUC-Pte-104237	Pyrenophora teres	31.82	5.00e-34	137.00
IUUC-Pyt-104468	Pyrenophora triticirepentis	31.82	3.00e-34	138.00
IUUC-Rno-105204	Rattus norvegicus	96.03	1.00e-158	552.00
IUUC-Sha-106579	Sarcophilus harrisii	86.61	1.00e-126	445.00
IUUC-Smo-109525	Selaginella moellendorffii	36.13	5.00e-42	164.00
IUUC-Sit-110665	Setaria italica	35.00	3.00e-43	168.00
IUUC-Sly-111473	Solanum lycopersicum	37.59	1.00e-45	176.00
IUUC-Stu-112353	Solanum tuberosum	36.30	1.00e-43	169.00
IUUC-Sbi-114250	Sorghum bicolor	37.32	8.00e-45	173.00
IUUC-Ssc-115416	Sus scrofa	98.01	7.00e-177	612.00
IUUC-Tgu-117272	Taeniopygia guttata	93.40	5.00e-55	205.00
IUUC-Tru-117777	Takifugu rubripes	80.21	1.00e-128	452.00
IUUC-Tni-120572	Tetraodon nigroviridis	80.92	1.00e-129	456.00
IUUC-Tca-121149	Theobroma cacao	38.63	1.00e-49	189.00
IUUC-Tre-122230	Trichoderma reesei	32.60	2.00e-31	129.00
IUUC-Tvi-122678	Trichoderma virens	35.64	5.00e-41	160.00
IUUC-Tae-122986	Triticum aestivum	35.53	7.00e-42	164.00
IUUC-Tur-126009	Triticum urartu	35.60	9.00e-38	150.00
IUUC-Tme-126948	Tuber melanosporum	36.10	1.00e-40	159.00
IUUC-Ttr-129031	Tursiops truncatus	95.35	1.00e-168	585.00
IUUC-Vda-130023	Verticillium dahliae	32.97	5.00e-39	154.00
IUUC-Vpa-130124	Vicugna pacos	33.07	6.00e-11	62.80
IUUC-Vvi-131091	Vitis vinifera	40.80	7.00e-25	105.00
IUUC-Xtr-132871	Xenopus tropicalis	83.81	8.00e-129	452.00
IUUC-Xma-134220	Xiphophorus maculatus	78.80	3.00e-127	447.00
IUUC-Yli-134462	Yarrowia lipolytica	28.98	1.00e-28	120.00
IUUC-Zma-135007	Zea mays	37.32	6.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence