iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073235

Ensembl Protein ID

ENSOANP00000017590.2

UniProt Accession

F7FCE3; F7FCE3_ORNAN

Genbank Protein ID

ENSOANP00000017590

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01187343

Gene Name

OTUD7A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000011103.5	ENSOANT00000017593.2	ENSOANP00000017590.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.40e-40	139.1	180	360
UBD/ZnF/ZnF_A20	3.00e-15	56.1	769	803

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k           e+e++++ kl+++e    
   Q: 180  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRSGAEKEALKRRWRWQQTQQNKesglvyteeewEREWTELLKLASSEprth 268
           6899*********************************************************************************8877 PP
   S: 75   .ak.g................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaL 135
            +k g                ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p++k +++p+vL+Y+++H++aL
   Q: 269  fSKnGgtgggvdnsrsvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNKcHCSPLVLAYDQAHFSAL 357
           7443377789******************************************************************************* PP
   S: 136  val 138
           v++
   Q: 358  VSM 360
           986 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           ++++ +Ckk +C+fYG+pet++yCS+Cy+eel+rr
   Q: 769  PQTQNRCKKeNCSFYGRPETENYCSYCYKEELKRR 803
           599*******************************9 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

LIYAHQFIIN NYLKGLTCNS NLIRDCVFTG KNWDLTAALG DYEQLRQVHT ANLPQVFNEG 60
KYYKPPEREP PQQVNKIDRP GLPRQDEIAQ EKRLSRGISH ASSAIVSLAR SHVANECNNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAATTTATG CACATCAGTT CATTATTAAT AATTATTTGA AAGGGTTAAC ATGTAATTCT 60
AACTTAATCA GGGACTGTTA AGGTTGTATG TCATCCATGA AATGAAGTCA AAATGTTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	82.03	0.00e+00	937.00
IUUC-Apl-003825	Anas platyrhynchos	82.58	0.00e+00	1187.00
IUUC-Aca-004392	Anolis carolinensis	76.82	0.00e+00	1172.00
IUUC-Ate-010308	Aspergillus terreus	34.15	6.20e-01	30.40
IUUC-Ame-011052	Astyanax mexicanus	66.74	0.00e+00	1045.00
IUUC-Bta-013296	Bos taurus	83.31	0.00e+00	925.00
IUUC-Cel-018468	Caenorhabditis elegans	45.02	4.00e-78	285.00
IUUC-Cja-019141	Callithrix jacchus	77.18	0.00e+00	890.00
IUUC-Cfa-020447	Canis familiaris	83.10	0.00e+00	932.00
IUUC-Cpo-022059	Cavia porcellus	83.70	0.00e+00	820.00
IUUC-Csa-023263	Chlorocebus sabaeus	79.57	0.00e+00	932.00
IUUC-Cho-024611	Choloepus hoffmanni	84.68	7.00e-163	566.00
IUUC-Csv-026177	Ciona savignyi	29.76	5.00e-03	33.90
IUUC-Dre-028617	Danio rerio	73.68	0.00e+00	874.00
IUUC-Dno-029121	Dasypus novemcinctus	79.13	0.00e+00	907.00
IUUC-Dor-031121	Dipodomys ordii	63.29	2.00e-142	498.00
IUUC-Ete-033068	Echinops telfairi	79.62	0.00e+00	889.00
IUUC-Eca-034413	Equus caballus	78.86	0.00e+00	893.00
IUUC-Eeu-034670	Erinaceus europaeus	56.19	0.00e+00	763.00
IUUC-Fca-036487	Felis catus	80.41	0.00e+00	907.00
IUUC-Fal-037145	Ficedula albicollis	75.33	0.00e+00	1182.00
IUUC-Fso-038203	Fusarium solani	26.23	2.50e-01	30.40
IUUC-Gmo-038786	Gadus morhua	59.22	0.00e+00	911.00
IUUC-Gga-040512	Gallus gallus	77.00	0.00e+00	1159.00
IUUC-Gac-041599	Gasterosteus aculeatus	78.09	0.00e+00	800.00
IUUC-Ggo-044819	Gorilla gorilla	81.90	0.00e+00	929.00
IUUC-Hsa-046781	Homo sapiens	78.34	0.00e+00	915.00
IUUC-Itr-048841	Ictidomys tridecemlineatus	57.04	0.00e+00	789.00
IUUC-Lch-050666	Latimeria chalumnae	75.62	0.00e+00	1155.00
IUUC-Loc-052841	Lepisosteus oculatus	84.49	0.00e+00	836.00
IUUC-Laf-053437	Loxodonta africana	80.28	0.00e+00	902.00
IUUC-Mcc-055353	Macaca mulatta	78.19	0.00e+00	913.00
IUUC-Meu-056477	Macropus eugenii	58.94	4.00e-172	597.00
IUUC-Mga-059741	Meleagris gallopavo	81.94	0.00e+00	1230.00
IUUC-Mmr-061437	Microcebus murinus	78.19	0.00e+00	972.00
IUUC-Mdo-061907	Monodelphis domestica	78.26	0.00e+00	1217.00
IUUC-Mmu-064074	Mus musculus	78.41	0.00e+00	923.00
IUUC-Mpu-066004	Mustela putorius furo	87.40	0.00e+00	948.00
IUUC-Mlu-068039	Myotis lucifugus	56.75	0.00e+00	800.00
IUUC-Nle-069182	Nomascus leucogenys	79.42	0.00e+00	931.00
IUUC-Opr-070701	Ochotona princeps	73.73	0.00e+00	800.00
IUUC-Ont-072431	Oreochromis niloticus	81.15	0.00e+00	794.00
IUUC-Ocu-073935	Oryctolagus cuniculus	81.26	0.00e+00	865.00
IUUC-Ola-087026	Oryzias latipes	64.90	0.00e+00	1056.00
IUUC-Oga-088249	Otolemur garnettii	79.60	0.00e+00	985.00
IUUC-Oar-089476	Ovis aries	69.38	0.00e+00	1043.00
IUUC-Ptr-090548	Pan troglodytes	78.03	0.00e+00	843.00
IUUC-Pan-092616	Papio anubis	72.14	0.00e+00	1032.00
IUUC-Psi-093126	Pelodiscus sinensis	77.84	0.00e+00	1190.00
IUUC-Pfo-096785	Poecilia formosa	81.47	0.00e+00	798.00
IUUC-Pab-098336	Pongo abelii	79.42	0.00e+00	931.00
IUUC-Pca-100206	Procavia capensis	77.23	0.00e+00	818.00
IUUC-Pva-102136	Pteropus vampyrus	56.51	0.00e+00	760.00
IUUC-Rno-105483	Rattus norvegicus	79.03	0.00e+00	687.00
IUUC-Sha-106617	Sarcophilus harrisii	87.07	0.00e+00	915.00
IUUC-Sar-113562	Sorex araneus	49.82	3.00e-173	601.00
IUUC-Ssc-115415	Sus scrofa	80.80	0.00e+00	910.00
IUUC-Tgu-117218	Taeniopygia guttata	83.57	0.00e+00	982.00
IUUC-Tru-118720	Takifugu rubripes	78.17	0.00e+00	767.00
IUUC-Tsy-119343	Tarsius syrichta	52.86	0.00e+00	720.00
IUUC-Tni-120795	Tetraodon nigroviridis	70.52	0.00e+00	1028.00
IUUC-Tbe-127283	Tupaia belangeri	72.62	9.00e-168	583.00
IUUC-Ttr-128692	Tursiops truncatus	53.03	0.00e+00	719.00
IUUC-Xtr-132158	Xenopus tropicalis	73.09	0.00e+00	1181.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence