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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-104835
UUCD1 version UUC-RaN-00805
Ensembl Protein ID ENSRNOP00000014553.3
UniProt Accession Q4KLM4; KLH25_RAT
Genbank Protein ID AAH99111.1
Protein Name Kelch-like protein 25; Ectoderm-neural cortex protein 2
Genbank Nucleotide ID BC099111
Gene Name Klhl25; Enc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000010959.4 ENSRNOT00000014553.4 ENSRNOP00000014553.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.00e-20 71.8 46 114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.30e-09 35.9 146 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaasS++F+a+f+++l+es+  ++v+++d + pev++ ll+F Y++++ +ne
   Q: 46   TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESR-DDTVNFQDnLHPEVLELLLDFAYSSRIVINE 114
           7*************************************.*******99*****************99886 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclg++ ++d+++c++L+++  ++ l hF+
   Q: 146  PSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFE 177
           89****************************95 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E (By similarity).
Protein Sequence
(Fasta)
MSVSVHETRK SRSSTGSMNI SVFHKASHPD CVLAHLNTLR KHCMFTDVTL WAGDRAFPCH 60
RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL LLDFAYSSRI VINEENAESL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-104835|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCGGTTCGG CTACGGGATC GCGGCCGGGA CTGGAGAGCC GGCCGGGGAC GGCGGCAGCG 60
GCGGGGACTG CGGAGCCTGT GGGGCCCCAC GGTGAGGACC AGGTCGGGAC CGAGTCGACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104835|E3,BTB_3-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation
KEGG rno:293023
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002373 Ailuropoda melanoleuca 95.08 0.00e+00 1177.00
IUUC-Apl-003543 Anas platyrhynchos 87.63 0.00e+00 1063.00
IUUC-Aca-004729 Anolis carolinensis 86.25 0.00e+00 1056.00
IUUC-Ame-011020 Astyanax mexicanus 83.36 0.00e+00 1013.00
IUUC-Bta-012955 Bos taurus 92.70 0.00e+00 1155.00
IUUC-Cja-018839 Callithrix jacchus 94.06 0.00e+00 1164.00
IUUC-Cfa-020224 Canis familiaris 95.25 0.00e+00 1174.00
IUUC-Cpo-021593 Cavia porcellus 91.00 0.00e+00 1095.00
IUUC-Csa-023276 Chlorocebus sabaeus 94.74 0.00e+00 1172.00
IUUC-Dre-028053 Danio rerio 83.36 0.00e+00 989.00
IUUC-Dno-029287 Dasypus novemcinctus 91.85 0.00e+00 1142.00
IUUC-Dor-030908 Dipodomys ordii 85.74 0.00e+00 1038.00
IUUC-Fca-035897 Felis catus 95.08 0.00e+00 1177.00
IUUC-Fal-037036 Ficedula albicollis 87.78 0.00e+00 1070.00
IUUC-Gmo-039345 Gadus morhua 83.02 0.00e+00 980.00
IUUC-Gga-040404 Gallus gallus 87.61 0.00e+00 1071.00
IUUC-Gac-042447 Gasterosteus aculeatus 82.85 0.00e+00 997.00
IUUC-Ggo-045060 Gorilla gorilla 94.91 0.00e+00 1173.00
IUUC-Hsa-046494 Homo sapiens 94.74 0.00e+00 1172.00
IUUC-Itr-047993 Ictidomys tridecemlineatus 95.42 0.00e+00 1175.00
IUUC-Lch-050211 Latimeria chalumnae 85.54 0.00e+00 1034.00
IUUC-Loc-052578 Lepisosteus oculatus 83.02 0.00e+00 1015.00
IUUC-Laf-053498 Loxodonta africana 93.04 0.00e+00 1108.00
IUUC-Mcc-055033 Macaca mulatta 94.57 0.00e+00 1171.00
IUUC-Meu-056893 Macropus eugenii 90.32 0.00e+00 1121.00
IUUC-Mga-060025 Meleagris gallopavo 87.78 0.00e+00 1071.00
IUUC-Mmr-060658 Microcebus murinus 93.55 0.00e+00 1167.00
IUUC-Mdo-062667 Monodelphis domestica 90.15 0.00e+00 1117.00
IUUC-Mmu-063125 Mus musculus 99.15 0.00e+00 1192.00
IUUC-Mpu-066209 Mustela putorius furo 95.08 0.00e+00 1176.00
IUUC-Mlu-068237 Myotis lucifugus 90.66 0.00e+00 1103.00
IUUC-Nle-069454 Nomascus leucogenys 94.85 0.00e+00 1159.00
IUUC-Ont-072138 Oreochromis niloticus 83.02 0.00e+00 984.00
IUUC-Oan-073320 Ornithorhynchus anatinus 83.53 0.00e+00 1048.00
IUUC-Ocu-073765 Oryctolagus cuniculus 86.76 0.00e+00 1062.00
IUUC-Oga-088002 Otolemur garnettii 93.89 0.00e+00 1159.00
IUUC-Oar-089481 Ovis aries 92.02 0.00e+00 1149.00
IUUC-Ptr-091200 Pan troglodytes 94.91 0.00e+00 1176.00
IUUC-Psi-093884 Pelodiscus sinensis 87.78 0.00e+00 1061.00
IUUC-Pno-095143 Phaeosphaeria nodorum 28.11 1.00e-14 73.90
IUUC-Pva-102321 Pteropus vampyrus 93.21 0.00e+00 1157.00
IUUC-Sha-107528 Sarcophilus harrisii 90.15 0.00e+00 1120.00
IUUC-Ssc-116161 Sus scrofa 94.74 0.00e+00 1171.00
IUUC-Tgu-116569 Taeniopygia guttata 87.61 0.00e+00 1066.00
IUUC-Tni-120525 Tetraodon nigroviridis 74.28 0.00e+00 857.00
IUUC-Ttr-129297 Tursiops truncatus 94.06 0.00e+00 1165.00
Created Date 25-Jun-2017

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