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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105547
Ensembl Protein ID ENSRNOP00000051338.5
UniProt Accession D3ZZH6; D3ZZH6_RAT
Genbank Protein ID ENSRNOP00000051338
Protein Name Mitogen-activated protein kinase kinase kinase 5
Genbank Nucleotide ID AABR07000495
Gene Name Map3k5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000031700.6 ENSRNOT00000051496.6 ENSRNOP00000051338.5
ENSRNOG00000031700.6 ENSRNOT00000067070.3 ENSRNOP00000063417.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 92.89 0.00e+00 2414.00 IUUC-Hsa-046906
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MGTEAGEGIT FSVPPILSAG FCPIPEGGSC RRGGGAATAA EGEPSLQPLL MPPPPPPPGS 60
FWNVESAAAP GTSCPTTAPG SSATRGRGNS GSGGGRRTTV AYVINEASQG QLVVAESEAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105547|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCACCG AAGCCGGCGA GGGCATCACT TTCTCCGTGC CGCCCATTTT GTCCGCGGGT 60
TTCTGCCCCA TCCCGGAGGG CGGCAGCTGC CGGAGGGGAG GAGGAGCGGC GACGGCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105547|ULD,UBQ_Other|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR025136--DUF4071
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR013761--SAM/pointed
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF13281--DUF4071
PF00069--Pkinase
SMART

SM00220--S_TKc
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0009897--C:external side of plasma membrane
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:1902911--C:protein kinase complex
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0000187--P:activation of MAPK activity
GO:0070301--P:cellular response to hydrogen peroxide
GO:1902170--P:cellular response to reactive nitrogen species
GO:0071356--P:cellular response to tumor necrosis factor
GO:0072577--P:endothelial cell apoptotic process
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254--P:JNK cascade
GO:0038066--P:p38MAPK cascade
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901216--P:positive regulation of neuron death
GO:1900745--P:positive regulation of p38MAPK cascade
GO:0001934--P:positive regulation of protein phosphorylation
GO:1904707--P:positive regulation of vascular smooth muscle cell proliferation
GO:0097300--P:programmed necrotic cell death
GO:0034976--P:response to endoplasmic reticulum stress
GO:0002931--P:response to ischemia
GO:0042060--P:wound healing
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002318 Ailuropoda melanoleuca 94.13 0.00e+00 2272.00
IUUC-Apl-003713 Anas platyrhynchos 87.67 0.00e+00 2051.00
IUUC-Aca-005331 Anolis carolinensis 86.50 0.00e+00 2039.00
IUUC-Ame-011158 Astyanax mexicanus 74.86 0.00e+00 1824.00
IUUC-Bta-012770 Bos taurus 91.88 0.00e+00 2370.00
IUUC-Cja-019656 Callithrix jacchus 92.39 0.00e+00 2409.00
IUUC-Cfa-020488 Canis familiaris 91.80 0.00e+00 2373.00
IUUC-Cpo-022516 Cavia porcellus 93.26 0.00e+00 2272.00
IUUC-Csa-023104 Chlorocebus sabaeus 95.40 0.00e+00 2253.00
IUUC-Cho-024379 Choloepus hoffmanni 87.32 0.00e+00 1185.00
IUUC-Dre-028836 Danio rerio 74.03 0.00e+00 1849.00
IUUC-Dno-029842 Dasypus novemcinctus 91.52 0.00e+00 2149.00
IUUC-Dor-030990 Dipodomys ordii 93.64 0.00e+00 1892.00
IUUC-Ete-032693 Echinops telfairi 81.90 0.00e+00 1920.00
IUUC-Eca-033337 Equus caballus 93.32 0.00e+00 2258.00
IUUC-Eeu-034602 Erinaceus europaeus 77.37 0.00e+00 1946.00
IUUC-Fca-035954 Felis catus 93.61 0.00e+00 1870.00
IUUC-Fal-037358 Ficedula albicollis 87.16 0.00e+00 2075.00
IUUC-Gmo-038836 Gadus morhua 77.89 0.00e+00 1740.00
IUUC-Gga-040443 Gallus gallus 87.66 0.00e+00 2204.00
IUUC-Gac-041634 Gasterosteus aculeatus 74.96 0.00e+00 1916.00
IUUC-Ggo-045263 Gorilla gorilla 90.96 0.00e+00 2345.00
IUUC-Hsa-046906 Homo sapiens 92.89 0.00e+00 2426.00
IUUC-Itr-048449 Ictidomys tridecemlineatus 94.03 0.00e+00 1094.00
IUUC-Lch-050213 Latimeria chalumnae 78.04 0.00e+00 1783.00
IUUC-Loc-051829 Lepisosteus oculatus 75.64 0.00e+00 1848.00
IUUC-Laf-053538 Loxodonta africana 92.17 0.00e+00 2411.00
IUUC-Mcc-054776 Macaca mulatta 93.26 0.00e+00 2441.00
IUUC-Mga-059636 Meleagris gallopavo 87.45 0.00e+00 2106.00
IUUC-Mmr-061323 Microcebus murinus 92.75 0.00e+00 2367.00
IUUC-Mdo-062146 Monodelphis domestica 89.05 0.00e+00 2282.00
IUUC-Mmu-064022 Mus musculus 96.81 0.00e+00 2449.00
IUUC-Mpu-066531 Mustela putorius furo 89.66 0.00e+00 2365.00
IUUC-Mlu-068181 Myotis lucifugus 88.03 0.00e+00 2333.00
IUUC-Nle-069758 Nomascus leucogenys 95.23 0.00e+00 2248.00
IUUC-Opr-070531 Ochotona princeps 87.33 0.00e+00 1452.00
IUUC-Ont-072014 Oreochromis niloticus 77.10 0.00e+00 1891.00
IUUC-Oan-073169 Ornithorhynchus anatinus 91.76 0.00e+00 2197.00
IUUC-Ocu-074050 Oryctolagus cuniculus 90.35 0.00e+00 2116.00
IUUC-Ola-086941 Oryzias latipes 79.81 0.00e+00 1538.00
IUUC-Oga-088796 Otolemur garnettii 92.17 0.00e+00 2360.00
IUUC-Oar-090445 Ovis aries 94.60 0.00e+00 2243.00
IUUC-Ptr-090846 Pan troglodytes 92.82 0.00e+00 2429.00
IUUC-Pan-091986 Papio anubis 93.18 0.00e+00 2437.00
IUUC-Psi-093805 Pelodiscus sinensis 87.26 0.00e+00 2192.00
IUUC-Pfo-097301 Poecilia formosa 75.86 0.00e+00 1899.00
IUUC-Pab-097662 Pongo abelii 94.47 0.00e+00 2383.00
IUUC-Pca-100755 Procavia capensis 92.48 0.00e+00 708.00
IUUC-Pva-102280 Pteropus vampyrus 84.55 0.00e+00 2182.00
IUUC-Sha-106859 Sarcophilus harrisii 88.32 0.00e+00 2241.00
IUUC-Sar-113714 Sorex araneus 81.98 0.00e+00 1890.00
IUUC-Tgu-117116 Taeniopygia guttata 86.06 0.00e+00 2141.00
IUUC-Tru-118088 Takifugu rubripes 76.13 0.00e+00 1922.00
IUUC-Tsy-119616 Tarsius syrichta 87.97 0.00e+00 1960.00
IUUC-Tni-120284 Tetraodon nigroviridis 74.98 0.00e+00 1870.00
IUUC-Tbe-127900 Tupaia belangeri 92.02 0.00e+00 812.00
IUUC-Ttr-128294 Tursiops truncatus 83.42 0.00e+00 2051.00
IUUC-Vpa-130470 Vicugna pacos 84.71 0.00e+00 1992.00
IUUC-Xtr-132396 Xenopus tropicalis 73.77 0.00e+00 1920.00
Created Date 25-Jun-2017

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