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Tag Content
iUUCD ID IUUC-Mmr-060890
Ensembl Protein ID ENSMICP00000012241.2
UniProt Accession P79801; PSN2_MICMU
Genbank Protein ID CAA71228.1
Protein Name Presenilin-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit
Genbank Nucleotide ID Y10140
Gene Name PSEN2; PS2; PSNL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMICG00000013427.2 ENSMICT00000038881.1 ENSMICP00000020216.1
ENSMICG00000013427.2 ENSMICT00000013422.2 ENSMICP00000012241.2
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/CUE 5.20e-08 33.5 278 316
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/CUE
   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP
   
Organism Microcebus murinus
Functional Description
(View)

Functional Description


     Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity).
 Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity).
Protein Sequence
(Fasta)
MLTFMASDSE EEVCDERTSL MSAESPSPRS CQEGGQGPED GDSTAQWRIQ DSEEDGEEDP 60
DRYVSSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmr-060890|UBD,CUE|Microcebus murinus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCCGCGCA GCCCCCAGGC CTGCGCCCGG CCCCAGCCGC TCCTCGCGCC CCCGCCGGAG 60
ACCCCGCCAG AGCTGGGGCG CCGCGCGAGC TGTTGGAGGG CCGGTGCATT GAAAGGCACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmr-060890|UBD,CUE|Microcebus murinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2
SMART

SM00730--PSN
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 58.02 2.00e-15 78.20
IUUC-Aml-002356 Ailuropoda melanoleuca 87.50 2.00e-176 612.00
IUUC-Atr-003039 Amborella trichopoda 31.42 4.00e-19 89.40
IUUC-Apl-003959 Anas platyrhynchos 76.12 3.00e-162 564.00
IUUC-Aca-005160 Anolis carolinensis 75.28 4.00e-158 550.00
IUUC-Aly-005455 Arabidopsis lyrata 61.73 3.00e-17 82.80
IUUC-Ath-006730 Arabidopsis thaliana 61.73 3.00e-17 82.80
IUUC-Ang-009768 Aspergillus niger 50.00 8.30e-01 28.90
IUUC-Ame-010686 Astyanax mexicanus 80.63 8.00e-147 513.00
IUUC-Bta-013097 Bos taurus 94.65 0.00e+00 709.00
IUUC-Bdi-014196 Brachypodium distachyon 38.32 1.00e-18 87.80
IUUC-Bol-015841 Brassica oleracea 58.62 1.00e-17 84.00
IUUC-Bra-017580 Brassica rapa 58.62 2.00e-17 83.60
IUUC-Cel-018553 Caenorhabditis elegans 48.58 9.00e-94 337.00
IUUC-Cja-018824 Callithrix jacchus 94.20 0.00e+00 724.00
IUUC-Cfa-020253 Canis familiaris 94.20 0.00e+00 724.00
IUUC-Cpo-021401 Cavia porcellus 94.64 0.00e+00 727.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 34.56 4.00e-29 122.00
IUUC-Csa-023369 Chlorocebus sabaeus 96.21 0.00e+00 750.00
IUUC-Cin-025780 Ciona intestinalis 61.40 5.00e-117 414.00
IUUC-Csv-025967 Ciona savignyi 60.14 4.00e-118 417.00
IUUC-Dre-028526 Danio rerio 70.20 3.00e-144 504.00
IUUC-Dor-031127 Dipodomys ordii 89.96 0.00e+00 675.00
IUUC-Dme-031929 Drosophila melanogaster 65.35 2.00e-83 302.00
IUUC-Ete-033081 Echinops telfairi 83.33 4.00e-93 334.00
IUUC-Eca-034387 Equus caballus 95.09 0.00e+00 688.00
IUUC-Eeu-034846 Erinaceus europaeus 79.71 4.00e-147 514.00
IUUC-Fca-035396 Felis catus 93.51 0.00e+00 734.00
IUUC-Fal-037457 Ficedula albicollis 76.09 3.00e-161 561.00
IUUC-Gmo-038550 Gadus morhua 82.33 6.00e-105 374.00
IUUC-Gga-040706 Gallus gallus 76.25 6.00e-157 546.00
IUUC-Gac-042511 Gasterosteus aculeatus 66.24 1.00e-128 452.00
IUUC-Gma-043822 Glycine max 36.88 1.00e-22 100.00
IUUC-Ggo-045338 Gorilla gorilla 96.43 0.00e+00 750.00
IUUC-Hsa-046455 Homo sapiens 96.43 0.00e+00 750.00
IUUC-Hvu-047141 Hordeum vulgare 59.26 3.00e-16 79.70
IUUC-Itr-048731 Ictidomys tridecemlineatus 95.31 0.00e+00 736.00
IUUC-Lch-049638 Latimeria chalumnae 68.03 2.00e-144 505.00
IUUC-Lpe-051132 Leersia perrieri 37.68 7.00e-18 85.10
IUUC-Loc-052427 Lepisosteus oculatus 74.34 2.00e-157 548.00
IUUC-Laf-053758 Loxodonta africana 88.91 0.00e+00 718.00
IUUC-Mcc-054755 Macaca mulatta 96.21 0.00e+00 748.00
IUUC-Mtr-058392 Medicago truncatula 33.25 7.00e-30 124.00
IUUC-Mga-059466 Meleagris gallopavo 72.22 3.00e-127 448.00
IUUC-Mdo-062197 Monodelphis domestica 80.09 5.00e-177 613.00
IUUC-Mmu-063823 Mus musculus 94.87 0.00e+00 735.00
IUUC-Mac-064858 Musa acuminata 43.86 3.00e-23 102.00
IUUC-Mpu-066181 Mustela putorius furo 94.20 0.00e+00 726.00
IUUC-Nle-069596 Nomascus leucogenys 96.20 0.00e+00 699.00
IUUC-Opr-070344 Ochotona princeps 93.30 0.00e+00 735.00
IUUC-Ont-071867 Oreochromis niloticus 71.69 7.00e-134 470.00
IUUC-Oan-073378 Ornithorhynchus anatinus 74.58 1.00e-153 536.00
IUUC-Ocu-074652 Oryctolagus cuniculus 93.75 0.00e+00 692.00
IUUC-Oba-075256 Oryza barthii 60.49 2.00e-16 80.10
IUUC-Obr-076302 Oryza brachyantha 36.96 4.00e-17 82.80
IUUC-Ogl-077097 Oryza glaberrima 36.96 7.00e-17 81.60
IUUC-Ogu-078570 Oryza glumaepatula 36.96 6.00e-17 82.00
IUUC-Oin-079244 Oryza indica 37.68 5.00e-17 82.40
IUUC-Olo-080484 Oryza longistaminata 60.49 8.00e-17 80.90
IUUC-Ome-081814 Oryza meridionalis 36.96 5.00e-17 82.40
IUUC-Oni-082057 Oryza nivara 37.68 4.00e-17 82.40
IUUC-Opu-084176 Oryza punctata 34.03 7.00e-17 81.60
IUUC-Oru-084618 Oryza rufipogon 37.68 4.00e-17 82.40
IUUC-Osa-085602 Oryza sativa 37.68 4.00e-17 82.40
IUUC-Ola-086707 Oryzias latipes 70.82 3.00e-106 377.00
IUUC-Olu-087811 Ostreococcus lucimarinus 38.15 1.00e-46 180.00
IUUC-Oga-088560 Otolemur garnettii 96.01 0.00e+00 708.00
IUUC-Oar-089200 Ovis aries 94.43 0.00e+00 692.00
IUUC-Ptr-090569 Pan troglodytes 96.21 0.00e+00 748.00
IUUC-Pan-091742 Papio anubis 96.21 0.00e+00 747.00
IUUC-Psi-093297 Pelodiscus sinensis 74.52 2.00e-132 464.00
IUUC-Pma-094612 Petromyzon marinus 77.31 8.00e-127 446.00
IUUC-Ppa-095431 Physcomitrella patens 32.17 2.00e-28 120.00
IUUC-Pfo-097396 Poecilia formosa 67.58 2.00e-127 449.00
IUUC-Pab-098531 Pongo abelii 96.21 0.00e+00 750.00
IUUC-Pop-099661 Populus trichocarpa 32.27 9.00e-30 124.00
IUUC-Pca-101120 Procavia capensis 91.52 0.00e+00 706.00
IUUC-Ppe-101495 Prunus persica 32.88 4.00e-21 95.90
IUUC-Pva-102934 Pteropus vampyrus 85.04 0.00e+00 681.00
IUUC-Rno-106052 Rattus norvegicus 93.08 0.00e+00 739.00
IUUC-Sha-106876 Sarcophilus harrisii 79.74 1.00e-173 602.00
IUUC-Smo-109325 Selaginella moellendorffii 36.86 1.00e-30 127.00
IUUC-Sit-110624 Setaria italica 58.02 7.00e-16 78.60
IUUC-Stu-112433 Solanum tuberosum 33.79 3.00e-18 86.30
IUUC-Sar-113169 Sorex araneus 66.19 2.00e-96 345.00
IUUC-Sbi-114305 Sorghum bicolor 47.83 2.00e-16 80.10
IUUC-Ssc-115380 Sus scrofa 96.43 0.00e+00 766.00
IUUC-Tgu-117280 Taeniopygia guttata 76.74 1.00e-161 562.00
IUUC-Tru-117732 Takifugu rubripes 68.26 6.00e-121 427.00
IUUC-Tni-119852 Tetraodon nigroviridis 64.74 4.00e-113 401.00
IUUC-Tca-121865 Theobroma cacao 34.44 8.00e-19 88.20
IUUC-Tae-125925 Triticum aestivum 59.26 3.00e-16 79.70
IUUC-Tur-126237 Triticum urartu 59.26 3.00e-16 79.30
IUUC-Tbe-127632 Tupaia belangeri 95.88 3.00e-179 620.00
IUUC-Ttr-129008 Tursiops truncatus 94.42 0.00e+00 723.00
IUUC-Vvi-131312 Vitis vinifera 37.06 6.00e-19 88.60
IUUC-Xtr-132756 Xenopus tropicalis 72.03 6.00e-161 560.00
IUUC-Xma-133377 Xiphophorus maculatus 67.93 3.00e-125 441.00
Created Date 25-Jun-2017

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