iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089200

Ensembl Protein ID

ENSOARP00000001441.1

UniProt Accession

W5NTE9; W5NTE9_SHEEP

Genbank Protein ID

ENSOARP00000001441

Protein Name

Presenilin

Genbank Nucleotide ID

AMGL01021101

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000001381.1	ENSOART00000001481.1	ENSOARP00000001441.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.50e-08	33.5	274	312

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 274  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 312
           89********************************99986 PP

Organism

Ovis aries

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQDGDGESAA QWRSQESEED REEEDPDRYV 60
CSGVPGRPPG LEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE KNGQLIYTPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCACAT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGATGAGCG GACGTCCCTG 60
ATGTCAGCCG AGAGCCCCAC GCCGCGCTCC TGCCAGGACG GCCAGACGGA GAGAGTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	87.31	2.00e-175	608.00
IUUC-Apl-003959	Anas platyrhynchos	77.42	6.00e-162	563.00
IUUC-Aca-005160	Anolis carolinensis	76.08	6.00e-158	550.00
IUUC-Ame-010686	Astyanax mexicanus	78.65	9.00e-147	513.00
IUUC-Bta-013097	Bos taurus	98.66	0.00e+00	728.00
IUUC-Cja-018824	Callithrix jacchus	93.99	0.00e+00	692.00
IUUC-Cfa-020253	Canis familiaris	94.43	0.00e+00	704.00
IUUC-Cpo-021401	Cavia porcellus	94.65	0.00e+00	702.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	5.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.32	0.00e+00	710.00
IUUC-Dre-028526	Danio rerio	69.69	5.00e-144	504.00
IUUC-Dor-031127	Dipodomys ordii	89.98	0.00e+00	655.00
IUUC-Ete-033081	Echinops telfairi	84.40	6.00e-94	337.00
IUUC-Eca-034387	Equus caballus	94.43	0.00e+00	686.00
IUUC-Eeu-034846	Erinaceus europaeus	79.47	2.00e-146	512.00
IUUC-Fca-035396	Felis catus	93.30	0.00e+00	738.00
IUUC-Fal-037457	Ficedula albicollis	76.52	2.00e-160	558.00
IUUC-Gmo-038550	Gadus morhua	82.76	1.00e-105	376.00
IUUC-Gga-040706	Gallus gallus	77.63	4.00e-156	544.00
IUUC-Gac-042511	Gasterosteus aculeatus	65.81	2.00e-128	452.00
IUUC-Ggo-045338	Gorilla gorilla	95.55	0.00e+00	711.00
IUUC-Hsa-046455	Homo sapiens	95.55	0.00e+00	711.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	94.88	0.00e+00	707.00
IUUC-Lch-049638	Latimeria chalumnae	68.61	1.00e-144	506.00
IUUC-Loc-052427	Lepisosteus oculatus	74.55	1.00e-153	536.00
IUUC-Laf-053758	Loxodonta africana	88.08	0.00e+00	684.00
IUUC-Mcc-054755	Macaca mulatta	95.55	0.00e+00	710.00
IUUC-Mmr-060890	Microcebus murinus	93.76	0.00e+00	695.00
IUUC-Mdo-062197	Monodelphis domestica	80.57	2.00e-175	608.00
IUUC-Mmu-063823	Mus musculus	93.76	0.00e+00	700.00
IUUC-Mac-064858	Musa acuminata	43.86	9.00e-23	100.00
IUUC-Mpu-066181	Mustela putorius furo	94.21	0.00e+00	702.00
IUUC-Nle-069596	Nomascus leucogenys	94.95	0.00e+00	660.00
IUUC-Opr-070344	Ochotona princeps	93.54	0.00e+00	726.00
IUUC-Ont-071867	Oreochromis niloticus	70.63	2.00e-133	468.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.94	4.00e-152	530.00
IUUC-Ocu-074652	Oryctolagus cuniculus	93.32	0.00e+00	689.00
IUUC-Obr-076302	Oryza brachyantha	36.96	8.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	67.73	8.00e-105	373.00
IUUC-Oga-088560	Otolemur garnettii	93.36	0.00e+00	684.00
IUUC-Ptr-090569	Pan troglodytes	95.32	0.00e+00	709.00
IUUC-Pan-091742	Papio anubis	95.55	0.00e+00	711.00
IUUC-Psi-093297	Pelodiscus sinensis	77.03	7.00e-131	460.00
IUUC-Pma-094612	Petromyzon marinus	77.57	6.00e-128	450.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	1.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	95.32	0.00e+00	710.00
IUUC-Pca-101120	Procavia capensis	91.09	0.00e+00	673.00
IUUC-Pva-102934	Pteropus vampyrus	85.30	0.00e+00	660.00
IUUC-Rno-106052	Rattus norvegicus	92.87	0.00e+00	712.00
IUUC-Sha-106876	Sarcophilus harrisii	79.31	1.00e-173	602.00
IUUC-Ssc-115380	Sus scrofa	96.21	0.00e+00	737.00
IUUC-Tgu-117280	Taeniopygia guttata	76.96	2.00e-160	558.00
IUUC-Tbe-127632	Tupaia belangeri	93.26	9.00e-176	609.00
IUUC-Ttr-129008	Tursiops truncatus	93.76	0.00e+00	690.00
IUUC-Xtr-132756	Xenopus tropicalis	72.98	4.00e-162	564.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence