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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064146
UUCD1 version UUC-MuM-00427
Ensembl Protein ID ENSMUSP00000124871.1
UniProt Accession Q4VGL6; B2RS13; Q69Z31; RC3H1_MOUSE
Genbank Protein ID AAY16368.1; BAD32613.1; AAI38664.1
Protein Name Roquin-1; Protein Sanroque; RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1
Genbank Nucleotide ID AY948287; AK173335; BC138663
Gene Name Rc3h1; Gm551; Kiaa2025
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040423.10 ENSMUST00000161609.7 ENSMUSP00000124871.1
ENSMUSG00000040423.10 ENSMUST00000035911.4 ENSMUSP00000037178.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACmiRecords
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 92.85 0.00e+00 1946.00 IUUC-Hsa-046163
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (PubMed:23663784). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (PubMed:26000482). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.
 Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (PubMed:23663784). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (PubMed:26000482). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4/Ox40 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation.
Protein Sequence
(Fasta)
MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD 60
IELLPVNSAL LQLVGAQIPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG 120
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Protein Fasta Sequence


>IUUC-Mmu-064146|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGAAGAGG AAGGGGACGA GGACAACGAG CGACGGGCGG CGGAGGACGC GGAGGAGGAA 60
GGGGAGGCCG ACCAACAAGA TGGCCCCTGC TGCAGGAGCA GCCTCAGCAG CAGCAGGTGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064146|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032671--RC3H1
IPR027370--Znf-RING_LisH
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00642--zf-CCCH
PF13445--zf-RING_UBOX
SMART

SM00184--RING
SM00356--ZnF_C3H1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0010494--C:cytoplasmic stress granule
GO:0000932--C:P-body
GO:0003730--F:mRNA 3'-UTR binding
GO:0003729--F:mRNA binding
GO:0003723--F:RNA binding
GO:0035613--F:RNA stem-loop binding
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0001782--P:B cell homeostasis
GO:0071347--P:cellular response to interleukin-1
GO:0033962--P:cytoplasmic mRNA processing body assembly
GO:0048535--P:lymph node development
GO:0046007--P:negative regulation of activated T cell proliferation
GO:0030889--P:negative regulation of B cell proliferation
GO:0002635--P:negative regulation of germinal center formation
GO:0045623--P:negative regulation of T-helper cell differentiation
GO:0000956--P:nuclear-transcribed mRNA catabolic process
GO:0000288--P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0061014--P:positive regulation of mRNA catabolic process
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0010468--P:regulation of gene expression
GO:0002634--P:regulation of germinal center formation
GO:0043488--P:regulation of mRNA stability
GO:0050856--P:regulation of T cell receptor signaling pathway
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0061470--P:T follicular helper cell differentiation
KEGG mmu:381305
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001700 Ailuropoda melanoleuca 93.55 0.00e+00 1914.00
IUUC-Apl-003290 Anas platyrhynchos 84.35 0.00e+00 1786.00
IUUC-Aca-004905 Anolis carolinensis 82.87 0.00e+00 1736.00
IUUC-Ame-011475 Astyanax mexicanus 63.92 0.00e+00 1207.00
IUUC-Cja-019907 Callithrix jacchus 93.03 0.00e+00 1949.00
IUUC-Cfa-020679 Canis familiaris 93.20 0.00e+00 1878.00
IUUC-Cpo-022110 Cavia porcellus 90.04 0.00e+00 1916.00
IUUC-Csa-024166 Chlorocebus sabaeus 93.37 0.00e+00 1887.00
IUUC-Dno-029870 Dasypus novemcinctus 89.71 0.00e+00 909.00
IUUC-Dor-030934 Dipodomys ordii 83.59 0.00e+00 1432.00
IUUC-Dme-031708 Drosophila melanogaster 64.71 1.00e-162 566.00
IUUC-Ete-032652 Echinops telfairi 93.51 0.00e+00 1350.00
IUUC-Eca-033236 Equus caballus 92.23 0.00e+00 1844.00
IUUC-Eeu-035091 Erinaceus europaeus 81.82 0.00e+00 861.00
IUUC-Fca-035773 Felis catus 93.12 0.00e+00 1869.00
IUUC-Fal-036972 Ficedula albicollis 84.78 0.00e+00 1814.00
IUUC-Gmo-039303 Gadus morhua 79.93 0.00e+00 893.00
IUUC-Ggo-044691 Gorilla gorilla 87.36 0.00e+00 1796.00
IUUC-Hsa-046163 Homo sapiens 93.20 0.00e+00 1954.00
IUUC-Itr-048266 Ictidomys tridecemlineatus 89.17 0.00e+00 995.00
IUUC-Lch-050667 Latimeria chalumnae 73.76 0.00e+00 1527.00
IUUC-Loc-052404 Lepisosteus oculatus 69.09 0.00e+00 1324.00
IUUC-Laf-053618 Loxodonta africana 93.44 0.00e+00 1832.00
IUUC-Mcc-054692 Macaca mulatta 93.29 0.00e+00 1958.00
IUUC-Meu-056025 Macropus eugenii 82.15 0.00e+00 903.00
IUUC-Mmr-061188 Microcebus murinus 93.11 0.00e+00 1878.00
IUUC-Mdo-063035 Monodelphis domestica 89.33 0.00e+00 1848.00
IUUC-Mpu-066217 Mustela putorius furo 92.57 0.00e+00 1866.00
IUUC-Mlu-068023 Myotis lucifugus 91.95 0.00e+00 1885.00
IUUC-Nle-069506 Nomascus leucogenys 93.29 0.00e+00 1959.00
IUUC-Opr-070587 Ochotona princeps 79.47 0.00e+00 1527.00
IUUC-Ont-071278 Oreochromis niloticus 62.25 0.00e+00 1195.00
IUUC-Oan-073500 Ornithorhynchus anatinus 88.65 0.00e+00 1914.00
IUUC-Ocu-074299 Oryctolagus cuniculus 92.38 0.00e+00 1784.00
IUUC-Ola-086665 Oryzias latipes 61.38 0.00e+00 1220.00
IUUC-Oga-088519 Otolemur garnettii 85.98 0.00e+00 1680.00
IUUC-Oar-089246 Ovis aries 91.40 0.00e+00 1761.00
IUUC-Ptr-091102 Pan troglodytes 93.29 0.00e+00 1956.00
IUUC-Pan-091952 Papio anubis 93.04 0.00e+00 1954.00
IUUC-Pfo-097227 Poecilia formosa 61.32 0.00e+00 1169.00
IUUC-Pab-097975 Pongo abelii 90.11 0.00e+00 1866.00
IUUC-Pca-101127 Procavia capensis 86.96 0.00e+00 1241.00
IUUC-Pva-102431 Pteropus vampyrus 84.63 0.00e+00 1662.00
IUUC-Sha-106690 Sarcophilus harrisii 88.63 0.00e+00 1878.00
IUUC-Ssc-116189 Sus scrofa 92.67 0.00e+00 1829.00
IUUC-Tgu-116527 Taeniopygia guttata 85.40 0.00e+00 1828.00
IUUC-Tru-118389 Takifugu rubripes 62.41 0.00e+00 1225.00
IUUC-Tsy-119193 Tarsius syrichta 90.37 0.00e+00 1814.00
IUUC-Tni-119790 Tetraodon nigroviridis 63.53 0.00e+00 1107.00
IUUC-Tbe-127445 Tupaia belangeri 94.82 0.00e+00 1284.00
IUUC-Ttr-128877 Tursiops truncatus 91.63 0.00e+00 1811.00
IUUC-Xtr-132274 Xenopus tropicalis 77.22 0.00e+00 1582.00
Created Date 25-Jun-2017

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