iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053802

Ensembl Protein ID

ENSLAFP00000004477.3

UniProt Accession

G3SW23; G3SW23_LOXAF

Protein Name

Tyrosine-protein kinase

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005345.3	ENSLAFT00000005348.3	ENSLAFP00000004477.3
ENSLAFG00000005345.3	ENSLAFT00000021902.2	ENSLAFP00000017461.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.70e-12	46.8	109	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 109  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 166
           67899************************.*********98..788899*********997 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGQQVSRVEE APGLQQPQPR GIRGSSAARP SDRRREPAGG SAEAGFNIFP QHDHFASCVE 60
DGFEGDKTGG SSPEALHRPY GCDVESQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCAGC AGGTGAGCCG CGTCGAGGAG GCTCCGGGTC TCCAGCAGCC GCAGCCCCGC 60
GGGATCCGGG GCAGCAGTGC AGCCAGGCCC TCCGACCGCA GGCGGGAGCC GGCGGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0071300--P:cellular response to retinoic acid
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	96.58	0.00e+00	2001.00
IUUC-Apl-003389	Anas platyrhynchos	85.24	0.00e+00	1758.00
IUUC-Ame-010629	Astyanax mexicanus	58.45	0.00e+00	1070.00
IUUC-Bta-013370	Bos taurus	95.44	0.00e+00	2075.00
IUUC-Cja-018894	Callithrix jacchus	94.40	0.00e+00	2007.00
IUUC-Cfa-020398	Canis familiaris	98.90	0.00e+00	1297.00
IUUC-Cpo-022367	Cavia porcellus	94.51	0.00e+00	1536.00
IUUC-Csa-023386	Chlorocebus sabaeus	96.49	0.00e+00	1993.00
IUUC-Cho-024714	Choloepus hoffmanni	91.54	0.00e+00	1889.00
IUUC-Dre-027741	Danio rerio	67.64	0.00e+00	1387.00
IUUC-Dno-029246	Dasypus novemcinctus	93.75	0.00e+00	2014.00
IUUC-Dor-030416	Dipodomys ordii	88.09	0.00e+00	1893.00
IUUC-Ete-032899	Echinops telfairi	77.63	0.00e+00	858.00
IUUC-Eca-033387	Equus caballus	96.91	0.00e+00	2013.00
IUUC-Eeu-035058	Erinaceus europaeus	84.56	0.00e+00	1872.00
IUUC-Fca-036578	Felis catus	89.56	0.00e+00	1810.00
IUUC-Fal-037491	Ficedula albicollis	87.88	0.00e+00	1879.00
IUUC-Gmo-038509	Gadus morhua	77.23	0.00e+00	1131.00
IUUC-Gga-040638	Gallus gallus	85.71	0.00e+00	1834.00
IUUC-Gac-042550	Gasterosteus aculeatus	67.29	0.00e+00	1325.00
IUUC-Ggo-044487	Gorilla gorilla	95.78	0.00e+00	2085.00
IUUC-Hsa-046636	Homo sapiens	95.86	0.00e+00	2085.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	96.02	0.00e+00	2030.00
IUUC-Lch-049530	Latimeria chalumnae	76.55	0.00e+00	1589.00
IUUC-Loc-051933	Lepisosteus oculatus	70.00	0.00e+00	1444.00
IUUC-Mcc-054836	Macaca mulatta	95.86	0.00e+00	2106.00
IUUC-Mga-059277	Meleagris gallopavo	88.05	0.00e+00	1850.00
IUUC-Mmr-061206	Microcebus murinus	94.76	0.00e+00	2024.00
IUUC-Mdo-062281	Monodelphis domestica	92.60	0.00e+00	1244.00
IUUC-Mmu-063847	Mus musculus	94.01	0.00e+00	1967.00
IUUC-Mac-065156	Musa acuminata	27.72	2.00e-22	100.00
IUUC-Mpu-066309	Mustela putorius furo	97.24	0.00e+00	1378.00
IUUC-Mlu-068070	Myotis lucifugus	96.13	0.00e+00	1991.00
IUUC-Nle-070062	Nomascus leucogenys	97.10	0.00e+00	1334.00
IUUC-Opr-070534	Ochotona princeps	90.60	0.00e+00	1068.00
IUUC-Ont-072440	Oreochromis niloticus	67.87	0.00e+00	1239.00
IUUC-Oan-073526	Ornithorhynchus anatinus	88.22	0.00e+00	1769.00
IUUC-Ocu-074051	Oryctolagus cuniculus	94.78	0.00e+00	1889.00
IUUC-Olo-080286	Oryza longistaminata	34.84	1.00e-23	105.00
IUUC-Opu-083538	Oryza punctata	35.29	2.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	34.84	9.00e-24	105.00
IUUC-Osa-085779	Oryza sativa	34.84	1.00e-23	105.00
IUUC-Ola-086752	Oryzias latipes	95.04	0.00e+00	914.00
IUUC-Oga-088767	Otolemur garnettii	90.31	0.00e+00	1797.00
IUUC-Oar-089800	Ovis aries	96.13	0.00e+00	1986.00
IUUC-Ptr-090857	Pan troglodytes	97.10	0.00e+00	1333.00
IUUC-Pan-092279	Papio anubis	94.09	0.00e+00	2021.00
IUUC-Psi-093573	Pelodiscus sinensis	88.53	0.00e+00	1823.00
IUUC-Pfo-096543	Poecilia formosa	61.69	0.00e+00	1253.00
IUUC-Pab-097949	Pongo abelii	94.09	0.00e+00	1986.00
IUUC-Pca-100370	Procavia capensis	95.25	0.00e+00	1482.00
IUUC-Pva-103220	Pteropus vampyrus	87.93	0.00e+00	1801.00
IUUC-Rno-105924	Rattus norvegicus	90.37	0.00e+00	1918.00
IUUC-Sha-107114	Sarcophilus harrisii	88.90	0.00e+00	1397.00
IUUC-Ssc-115968	Sus scrofa	95.02	0.00e+00	2143.00
IUUC-Tgu-117301	Taeniopygia guttata	87.35	0.00e+00	1792.00
IUUC-Tru-118410	Takifugu rubripes	65.95	0.00e+00	1395.00
IUUC-Tni-119991	Tetraodon nigroviridis	66.08	0.00e+00	1402.00
IUUC-Tca-121389	Theobroma cacao	33.33	3.00e-23	103.00
IUUC-Tae-125058	Triticum aestivum	31.98	6.00e-20	93.20
IUUC-Tbe-127362	Tupaia belangeri	90.88	0.00e+00	1878.00
IUUC-Ttr-129291	Tursiops truncatus	95.95	0.00e+00	1993.00
IUUC-Vpa-130800	Vicugna pacos	95.42	0.00e+00	1549.00
IUUC-Vvi-131057	Vitis vinifera	30.35	6.00e-22	99.80
IUUC-Xtr-132965	Xenopus tropicalis	67.72	0.00e+00	1443.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence