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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046425
UUCD1 version UUC-HoS-00891
Ensembl Protein ID ENSP00000341957.7
UniProt Accession Q13625; B4DG66; Q12892; Q86X75; Q96KQ3; ASPP2_HUMAN
Genbank Protein ID AAC50557.1; CAC83012.1; BAG57677.1; AAH46150.2; AAH58918.2; AAA21597.1
Protein Name Apoptosis-stimulating of p53 protein 2; Bcl2-binding protein; Renal carcinoma antigen NY-REN-51; Tumor suppressor p53-binding protein 2
Genbank Nucleotide ID U58334; AJ318888; AK294432; AC096542; BC058918; U09582
Gene Name TP53BP2; ASPP2; BBP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143514.16 ENST00000343537.11 ENSP00000341957.7
ENSG00000143514.16 ENST00000483398.5 ENSP00000417174.1
ENSG00000143514.16 ENST00000494100.1 ENSP00000420225.1
ENSG00000143514.16 ENST00000465119.1 ENSP00000418252.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRecordsRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDBSCOP
Disease-associated Variation
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 4.50e-12 47.4 1066 1118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
            ++ +l+dye+qnddeL +k+Gd +++i  ++e + +W+ +   l+ k+G +P n
   Q: 1066 GVIYALWDYEPQNDDELPMKEGDCMTIIhREDEDEIEWWWA--RLNDKEGYVPRN 1118
           56789***********************87888888***99..9*********99 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
 Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Protein Sequence
(Fasta)
MRFGSKMMPM FLTVYLSNNE QHFTEVPVTP ETICRDVVDL CKEPGESDCH LAEVWCGSER 60
PVADNERMFD VLQRFGSQRN EVRFFLRHER PPGRDIVSGP RSQDPSLKRN GVKVPGEYRR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046425|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTGGGGCCC GACCCGGGAT TAGTTGGTTT CGGAGCGGAG GAGGGAGCCC CGACCGTCAC 60
GAGCGTCGAA GAGACAAAGC CGCGTCAGGG GGCCCGGCCG GGGCGGGGGA GCCCGGGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046425|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
IPR029071--Ubiquitin-rel_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3
Pfam

PF12796--Ank_2
PF00018--SH3_1
PRINTS

PR01887--SPECTRNALPHA
SMART

SM00248--ANK
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0042802--F:identical protein binding
GO:0051059--F:NF-kappaB binding
GO:0002039--F:p53 binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007049--P:cell cycle
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045786--P:negative regulation of cell cycle
GO:1900119--P:positive regulation of execution phase of apoptosis
GO:1901216--P:positive regulation of neuron death
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0007165--P:signal transduction
KEGG hsa:7159
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001474 Ailuropoda melanoleuca 87.91 0.00e+00 1801.00
IUUC-Apl-003477 Anas platyrhynchos 78.95 0.00e+00 1522.00
IUUC-Aca-005300 Anolis carolinensis 76.97 0.00e+00 1566.00
IUUC-Bta-013530 Bos taurus 91.65 0.00e+00 1830.00
IUUC-Cja-019881 Callithrix jacchus 97.82 0.00e+00 660.00
IUUC-Cfa-021199 Canis familiaris 88.44 0.00e+00 1802.00
IUUC-Cpo-021960 Cavia porcellus 81.01 0.00e+00 1608.00
IUUC-Csa-023763 Chlorocebus sabaeus 98.41 0.00e+00 2092.00
IUUC-Cho-025060 Choloepus hoffmanni 83.82 0.00e+00 982.00
IUUC-Csv-025927 Ciona savignyi 65.17 1.00e-87 318.00
IUUC-Dno-029432 Dasypus novemcinctus 86.45 0.00e+00 1691.00
IUUC-Dor-030603 Dipodomys ordii 90.08 0.00e+00 1177.00
IUUC-Ete-032395 Echinops telfairi 71.79 0.00e+00 809.00
IUUC-Eca-034204 Equus caballus 91.64 0.00e+00 1887.00
IUUC-Eeu-035021 Erinaceus europaeus 76.65 0.00e+00 636.00
IUUC-Fca-035718 Felis catus 80.28 0.00e+00 1598.00
IUUC-Fal-037272 Ficedula albicollis 76.73 0.00e+00 1470.00
IUUC-Gga-040793 Gallus gallus 78.79 0.00e+00 1397.00
IUUC-Ggo-045018 Gorilla gorilla 98.76 0.00e+00 2122.00
IUUC-Itr-048708 Ictidomys tridecemlineatus 93.06 0.00e+00 1948.00
IUUC-Lch-050430 Latimeria chalumnae 69.22 0.00e+00 1362.00
IUUC-Loc-052603 Lepisosteus oculatus 56.10 0.00e+00 645.00
IUUC-Laf-054080 Loxodonta africana 90.15 0.00e+00 1897.00
IUUC-Mcc-055676 Macaca mulatta 98.50 0.00e+00 2089.00
IUUC-Meu-056686 Macropus eugenii 79.11 0.00e+00 931.00
IUUC-Mga-059342 Meleagris gallopavo 79.91 0.00e+00 1614.00
IUUC-Mmr-061245 Microcebus murinus 93.23 0.00e+00 1919.00
IUUC-Mdo-063015 Monodelphis domestica 85.15 0.00e+00 1779.00
IUUC-Mmu-063141 Mus musculus 91.01 0.00e+00 1882.00
IUUC-Mpu-065986 Mustela putorius furo 86.67 0.00e+00 1686.00
IUUC-Mlu-067869 Myotis lucifugus 86.76 0.00e+00 1765.00
IUUC-Nle-069765 Nomascus leucogenys 99.03 0.00e+00 2051.00
IUUC-Opr-070648 Ochotona princeps 87.40 0.00e+00 1761.00
IUUC-Oan-073404 Ornithorhynchus anatinus 84.04 0.00e+00 1709.00
IUUC-Ocu-074540 Oryctolagus cuniculus 89.87 0.00e+00 1811.00
IUUC-Ola-086986 Oryzias latipes 48.05 3.00e-143 503.00
IUUC-Oga-088550 Otolemur garnettii 91.61 0.00e+00 1880.00
IUUC-Oar-090212 Ovis aries 89.87 0.00e+00 1788.00
IUUC-Ptr-091623 Pan troglodytes 98.94 0.00e+00 2041.00
IUUC-Psi-093092 Pelodiscus sinensis 79.22 0.00e+00 1611.00
IUUC-Pab-098154 Pongo abelii 99.21 0.00e+00 2050.00
IUUC-Pca-100620 Procavia capensis 94.85 3.00e-162 566.00
IUUC-Pva-103003 Pteropus vampyrus 86.62 0.00e+00 1266.00
IUUC-Rno-105035 Rattus norvegicus 89.16 0.00e+00 1833.00
IUUC-Sha-106806 Sarcophilus harrisii 84.49 0.00e+00 1723.00
IUUC-Sar-113225 Sorex araneus 85.80 0.00e+00 1796.00
IUUC-Ssc-115981 Sus scrofa 91.12 0.00e+00 1801.00
IUUC-Tgu-116747 Taeniopygia guttata 73.86 0.00e+00 1014.00
IUUC-Tru-118643 Takifugu rubripes 45.76 0.00e+00 744.00
IUUC-Tsy-119114 Tarsius syrichta 90.64 0.00e+00 1912.00
IUUC-Tni-120786 Tetraodon nigroviridis 80.36 6.00e-116 412.00
IUUC-Ttr-128278 Tursiops truncatus 89.25 0.00e+00 1805.00
IUUC-Vpa-130152 Vicugna pacos 89.63 0.00e+00 810.00
Created Date 25-Jun-2017

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