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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046910
UUCD1 version UUC-HoS-00364
Ensembl Protein ID ENSP00000224862.3
UniProt Accession Q9H469; A1L4J8; B1AKX8; B1AKX9; B1AKY0; B1AKY1; C9JWA4; Q0D2Q3; Q49AL7; Q5JWA5; FXL15_HUMAN
Genbank Protein ID CAI12517.1; CAI12518.1; CAI12519.1; CAI12520.1; CAI12522.2; AAH02912.1; AAH36120.1; AAI30567.1
Protein Name F-box/LRR-repeat protein 15; F-box only protein 37
Genbank Nucleotide ID AL121928; AL121928; AL121928; AL121928; AL121928; BC002912; BC036120; BC130566
Gene Name FBXL15; FBXO37
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107872.12 ENST00000457067.1 ENSP00000392215.1
ENSG00000107872.12 ENST00000224862.7 ENSP00000224862.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 21572392
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Protein Sequence
(Fasta)
MEPPMEPSGG EQEPGAVRFL DLPWEDVLLP HVLNRVPLRQ LLRLQRVSRA FRSLVQLHLA 60
GLRRFDAAQV GPQIPRAALA RLLRDAEGLQ ELALAPCHEW LSDEDLVPVL ARNPQLRSVA 120
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Protein Fasta Sequence


>IUUC-Hsa-046910|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACACGGTATG GGTGTAGACT GGACCCGCCC CCTAAATCCA GGAGACCATC AACTATGGAA 60
AGGAGATCTA GGGAACACCG TCTTGAACCC GCCAGGGGTT TTGAGTCTCG GACCCAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046910|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
Pfam

PF00646--F-box
PF13516--LRR_6
SMART

SM00367--LRR_CC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030282--P:bone mineralization
GO:0009953--P:dorsal/ventral pattern formation
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG hsa:79176
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002259 Ailuropoda melanoleuca 93.33 9.00e-145 506.00
IUUC-Apl-003471 Anas platyrhynchos 66.21 4.00e-80 290.00
IUUC-Aca-005211 Anolis carolinensis 63.42 7.00e-102 363.00
IUUC-Ame-011477 Astyanax mexicanus 56.90 6.00e-95 340.00
IUUC-Bta-013461 Bos taurus 95.00 9.00e-160 555.00
IUUC-Cja-019278 Callithrix jacchus 97.99 9.00e-148 516.00
IUUC-Cfa-020248 Canis familiaris 96.67 2.00e-152 531.00
IUUC-Cpo-021313 Cavia porcellus 91.67 1.00e-129 455.00
IUUC-Csa-023633 Chlorocebus sabaeus 97.33 7.00e-163 566.00
IUUC-Cin-025760 Ciona intestinalis 30.59 4.00e-36 144.00
IUUC-Csv-025866 Ciona savignyi 31.54 4.00e-39 154.00
IUUC-Dre-027366 Danio rerio 58.42 1.00e-99 355.00
IUUC-Dno-029700 Dasypus novemcinctus 95.67 7.00e-150 523.00
IUUC-Dor-031069 Dipodomys ordii 92.62 5.00e-153 533.00
IUUC-Dme-031701 Drosophila melanogaster 31.52 1.00e-26 113.00
IUUC-Ete-032998 Echinops telfairi 86.29 2.00e-130 458.00
IUUC-Eca-034140 Equus caballus 96.33 2.00e-146 511.00
IUUC-Fca-035431 Felis catus 96.67 1.00e-151 529.00
IUUC-Fal-036960 Ficedula albicollis 65.25 1.00e-101 362.00
IUUC-Gmo-039411 Gadus morhua 57.09 1.00e-94 338.00
IUUC-Gga-040351 Gallus gallus 65.25 6.00e-100 357.00
IUUC-Gac-041972 Gasterosteus aculeatus 58.16 4.00e-87 314.00
IUUC-Ggo-044538 Gorilla gorilla 99.33 2.00e-150 525.00
IUUC-Itr-048011 Ictidomys tridecemlineatus 95.99 9.00e-150 522.00
IUUC-Lch-049710 Latimeria chalumnae 55.63 3.00e-99 354.00
IUUC-Loc-052288 Lepisosteus oculatus 59.04 1.00e-97 349.00
IUUC-Laf-053590 Loxodonta africana 86.73 2.00e-131 461.00
IUUC-Meu-056548 Macropus eugenii 79.50 3.00e-122 431.00
IUUC-Mga-059794 Meleagris gallopavo 64.18 2.00e-98 352.00
IUUC-Mmr-060829 Microcebus murinus 95.67 6.00e-150 523.00
IUUC-Mdo-062207 Monodelphis domestica 80.74 2.00e-133 468.00
IUUC-Mmu-063353 Mus musculus 96.33 1.00e-150 525.00
IUUC-Mpu-065841 Mustela putorius furo 97.00 6.00e-152 530.00
IUUC-Mlu-068035 Myotis lucifugus 93.08 1.00e-139 488.00
IUUC-Nle-069269 Nomascus leucogenys 98.67 2.00e-149 521.00
IUUC-Opr-070289 Ochotona princeps 88.14 1.00e-107 382.00
IUUC-Ont-072581 Oreochromis niloticus 55.52 2.00e-93 335.00
IUUC-Oan-073529 Ornithorhynchus anatinus 67.41 9.00e-79 286.00
IUUC-Ocu-074827 Oryctolagus cuniculus 95.67 5.00e-155 540.00
IUUC-Ola-087306 Oryzias latipes 56.04 8.00e-97 346.00
IUUC-Oga-088596 Otolemur garnettii 94.20 1.00e-133 469.00
IUUC-Oar-089473 Ovis aries 74.18 2.00e-81 294.00
IUUC-Ptr-091197 Pan troglodytes 99.67 6.00e-151 526.00
IUUC-Pan-092908 Papio anubis 98.00 6.00e-159 553.00
IUUC-Psi-093318 Pelodiscus sinensis 60.28 3.00e-68 251.00
IUUC-Pfo-097479 Poecilia formosa 56.76 1.00e-95 343.00
IUUC-Pab-097744 Pongo abelii 97.67 4.00e-148 517.00
IUUC-Pca-100930 Procavia capensis 91.00 3.00e-138 484.00
IUUC-Pva-102763 Pteropus vampyrus 87.14 4.00e-58 218.00
IUUC-Rno-105651 Rattus norvegicus 95.33 2.00e-154 538.00
IUUC-Tgu-117097 Taeniopygia guttata 65.96 1.00e-103 369.00
IUUC-Tru-118057 Takifugu rubripes 56.21 4.00e-94 337.00
IUUC-Tni-120693 Tetraodon nigroviridis 56.90 5.00e-94 337.00
IUUC-Tbe-127992 Tupaia belangeri 96.34 1.00e-101 363.00
IUUC-Xtr-132283 Xenopus tropicalis 56.51 1.00e-99 356.00
IUUC-Xma-134238 Xiphophorus maculatus 57.19 8.00e-95 340.00
Created Date 25-Jun-2017

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