iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069567

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01111865

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000017330.2	ENSNLET00000022101.2	ENSNLEP00000021044.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.60e-08	32.4	16	55
E3 activity/RING/U-box	2.40e-08	33.9	12	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl++f + p++  CgH f+++C+ ++      +     CP+Cr
   Q: 16   CPVCLDPFVE-PVSIECGHSFCQECISQV-----GKGVGSVCPVCR 55
           **********.***************999.....3444556****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  Cp+ l+++ +Pv +++G+++ +++I +  +  g+ cPv+rq++  ++l Pn  l ++++
   Q: 12   EEVTCPVCLDPFVEPVSIECGHSFCQECISQVGKGVGSVCPVCRQRFLLKNLRPNRQLANMVN 74
           6889***************************9899999******************9998876 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPVCL DPFVEPVSIE CGHSFCQECI SQVGKGVGSV CPVCRQRFLL 60
KNLRPNRQLA NMVNNLREIS QEAREGTQGE QCAVHGERLQ LFCEKDGKAL CWVCAQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCATGTACCC CACAAATATA TACACCTACT ATAGACACAT AAAATTGAAA ATTAAAAAAA 60
TTACTTTGGC AAATTTTATG TTCTATATGT TTTACGATTA AAGATAAAAA TAATATAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

KEGG

nle:100601201

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	77.78	0.00e+00	763.00
IUUC-Bta-013083	Bos taurus	72.80	0.00e+00	676.00
IUUC-Bol-016562	Brassica oleracea	47.92	8.00e-10	56.60
IUUC-Bra-016652	Brassica rapa	45.10	7.00e-10	58.20
IUUC-Cja-019002	Callithrix jacchus	92.00	0.00e+00	887.00
IUUC-Cfa-020415	Canis familiaris	75.05	0.00e+00	731.00
IUUC-Cpo-021948	Cavia porcellus	71.58	0.00e+00	685.00
IUUC-Csa-023135	Chlorocebus sabaeus	96.21	0.00e+00	848.00
IUUC-Cho-024493	Choloepus hoffmanni	66.08	2.00e-97	348.00
IUUC-Cne-026825	Cryptococcus neoformans	36.07	2.00e-04	42.00
IUUC-Dre-028064	Danio rerio	30.66	4.00e-63	235.00
IUUC-Dno-030061	Dasypus novemcinctus	71.80	0.00e+00	708.00
IUUC-Ete-033168	Echinops telfairi	69.63	9.00e-169	585.00
IUUC-Eca-033578	Equus caballus	80.94	0.00e+00	772.00
IUUC-Eeu-034749	Erinaceus europaeus	57.42	9.00e-131	459.00
IUUC-Fca-035468	Felis catus	73.47	0.00e+00	707.00
IUUC-Gac-041721	Gasterosteus aculeatus	35.89	1.00e-75	277.00
IUUC-Ggo-045190	Gorilla gorilla	96.84	0.00e+00	895.00
IUUC-Hsa-046583	Homo sapiens	97.47	0.00e+00	900.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	77.78	0.00e+00	726.00
IUUC-Lch-049548	Latimeria chalumnae	36.63	1.00e-78	286.00
IUUC-Laf-053455	Loxodonta africana	76.23	0.00e+00	682.00
IUUC-Mcc-054609	Macaca mulatta	96.21	0.00e+00	845.00
IUUC-Mmr-061369	Microcebus murinus	76.84	0.00e+00	664.00
IUUC-Mmu-063166	Mus musculus	70.28	0.00e+00	659.00
IUUC-Mpu-066889	Mustela putorius furo	75.21	0.00e+00	743.00
IUUC-Mlu-067647	Myotis lucifugus	79.44	0.00e+00	704.00
IUUC-Opr-071178	Ochotona princeps	63.16	6.00e-169	587.00
IUUC-Ont-072250	Oreochromis niloticus	33.78	2.00e-71	263.00
IUUC-Olu-087666	Ostreococcus lucimarinus	32.53	8.00e-11	61.60
IUUC-Oar-090413	Ovis aries	77.63	0.00e+00	700.00
IUUC-Ptr-091187	Pan troglodytes	97.47	0.00e+00	900.00
IUUC-Pan-092231	Papio anubis	96.15	0.00e+00	831.00
IUUC-Pma-094734	Petromyzon marinus	26.68	1.00e-24	107.00
IUUC-Ppa-095897	Physcomitrella patens	44.64	1.00e-08	54.30
IUUC-Pfo-096831	Poecilia formosa	32.93	2.00e-62	233.00
IUUC-Pab-098079	Pongo abelii	93.20	0.00e+00	627.00
IUUC-Pca-100639	Procavia capensis	73.26	7.00e-148	516.00
IUUC-Pva-102476	Pteropus vampyrus	77.89	0.00e+00	740.00
IUUC-Rno-105054	Rattus norvegicus	70.39	1.00e-173	602.00
IUUC-Sar-113204	Sorex araneus	73.17	0.00e+00	654.00
IUUC-Ssc-116291	Sus scrofa	76.71	0.00e+00	718.00
IUUC-Tsy-118803	Tarsius syrichta	78.99	3.00e-145	508.00
IUUC-Tbe-127337	Tupaia belangeri	62.35	9.00e-112	396.00
IUUC-Ttr-128914	Tursiops truncatus	76.71	0.00e+00	659.00
IUUC-Vpa-130566	Vicugna pacos	73.77	0.00e+00	646.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence