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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045764
UUCD1 version UUC-HoS-00785
Ensembl Protein ID ENSP00000410157.2
UniProt Accession Q8N961; A8K6S9; E9PRW7; Q52LD6; Q6MZW4; Q8NB44; ABTB2_HUMAN
Genbank Protein ID BAC03697.1; BAC04595.1; BAF84433.1; AAH93968.1; CAE45913.3
Protein Name Ankyrin repeat and BTB/POZ domain-containing protein 2
Genbank Nucleotide ID AK091560; AK095632; AK291744; AC090469; BX640841
Gene Name ABTB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166016.5 ENST00000435224.2 ENSP00000410157.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 7.60e-13 50.3 845 909
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgk 64
           +Dv++ v+g+ f ahk+ L ++S  F+ l++++ e +++s++++ei+d+++  f+ ++++lY g 
   Q: 845  SDVTFLVEGKLFYAHKVLLVTASNRFKTLMTNKSEqDGDSSKTIEISDMKYHIFQMMMQYLYYGG 909
           6*************************************************************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be involved in the initiation of hepatocyte growth.
 May be involved in the initiation of hepatocyte growth.
Protein Sequence
(Fasta)
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS 60
MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045764|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAGTTTGC AGAGCGCTTT CTCGCCGGCT GGTCCCGGAC TCGCGCTGCG CCCTGCGCCC 60
TGCGCCGCCG CCTCCTCCTT CTGCCGCCGC CGCCCTGTTC TCCCGGGATT CCTTCTCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045764|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000210--BTB/POZ_dom
IPR009072--Histone-fold
IPR011333--SKP1/BTB/POZ
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50097--BTB
Pfam

PF12796--Ank_2
PF00651--BTB
SMART

SM00248--ANK
SM00225--BTB
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0097237--P:cellular response to toxic substance
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG hsa:25841
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001268 Ailuropoda melanoleuca 95.12 0.00e+00 1625.00
IUUC-Atr-002568 Amborella trichopoda 31.92 2.00e-22 101.00
IUUC-Apl-003858 Anas platyrhynchos 86.20 0.00e+00 1756.00
IUUC-Aca-004669 Anolis carolinensis 86.08 0.00e+00 1321.00
IUUC-Aly-005776 Arabidopsis lyrata 34.38 5.00e-22 99.80
IUUC-Ath-006599 Arabidopsis thaliana 33.73 7.00e-22 99.40
IUUC-Ame-011542 Astyanax mexicanus 69.41 0.00e+00 1386.00
IUUC-Bta-013089 Bos taurus 96.79 0.00e+00 1916.00
IUUC-Bol-015629 Brassica oleracea 34.64 2.00e-21 97.80
IUUC-Cja-019035 Callithrix jacchus 98.57 0.00e+00 1676.00
IUUC-Cfa-020924 Canis familiaris 95.64 0.00e+00 1889.00
IUUC-Cpo-022186 Cavia porcellus 96.94 0.00e+00 1511.00
IUUC-Csa-023475 Chlorocebus sabaeus 99.41 0.00e+00 1967.00
IUUC-Cho-024429 Choloepus hoffmanni 75.80 2.00e-130 459.00
IUUC-Dre-028156 Danio rerio 70.11 0.00e+00 1392.00
IUUC-Dno-029691 Dasypus novemcinctus 93.56 0.00e+00 1770.00
IUUC-Dor-030365 Dipodomys ordii 97.26 0.00e+00 1451.00
IUUC-Dme-032128 Drosophila melanogaster 36.36 3.00e-162 566.00
IUUC-Eca-034033 Equus caballus 94.90 0.00e+00 1623.00
IUUC-Fca-036532 Felis catus 97.18 0.00e+00 1927.00
IUUC-Fal-037448 Ficedula albicollis 86.44 0.00e+00 1789.00
IUUC-Gmo-038752 Gadus morhua 69.03 0.00e+00 1385.00
IUUC-Gac-041934 Gasterosteus aculeatus 67.71 0.00e+00 1359.00
IUUC-Gma-044337 Glycine max 33.14 3.00e-22 100.00
IUUC-Ggo-044412 Gorilla gorilla 99.28 0.00e+00 1685.00
IUUC-Itr-048423 Ictidomys tridecemlineatus 98.05 0.00e+00 1926.00
IUUC-Lch-050679 Latimeria chalumnae 78.36 0.00e+00 1612.00
IUUC-Loc-052388 Lepisosteus oculatus 73.35 0.00e+00 1518.00
IUUC-Laf-053652 Loxodonta africana 95.90 0.00e+00 1389.00
IUUC-Mtr-057674 Medicago truncatula 34.34 1.00e-21 98.60
IUUC-Mga-059390 Meleagris gallopavo 85.87 0.00e+00 994.00
IUUC-Mdo-061833 Monodelphis domestica 93.43 0.00e+00 1337.00
IUUC-Mmu-063440 Mus musculus 96.98 0.00e+00 1876.00
IUUC-Mac-065013 Musa acuminata 31.25 8.00e-19 89.40
IUUC-Mpu-066600 Mustela putorius furo 96.39 0.00e+00 1887.00
IUUC-Mlu-067661 Myotis lucifugus 95.14 0.00e+00 1916.00
IUUC-Nle-069073 Nomascus leucogenys 95.61 0.00e+00 1833.00
IUUC-Opr-070832 Ochotona princeps 92.50 0.00e+00 1492.00
IUUC-Ont-071985 Oreochromis niloticus 69.30 0.00e+00 1400.00
IUUC-Oan-072689 Ornithorhynchus anatinus 83.40 0.00e+00 1215.00
IUUC-Ocu-074023 Oryctolagus cuniculus 96.88 0.00e+00 1911.00
IUUC-Oga-087929 Otolemur garnettii 96.98 0.00e+00 1936.00
IUUC-Oar-090225 Ovis aries 94.00 0.00e+00 1852.00
IUUC-Ptr-091075 Pan troglodytes 99.32 0.00e+00 1964.00
IUUC-Pan-091890 Papio anubis 97.66 0.00e+00 1944.00
IUUC-Psi-092948 Pelodiscus sinensis 85.39 0.00e+00 1760.00
IUUC-Ppa-095908 Physcomitrella patens 30.54 2.00e-22 101.00
IUUC-Pfo-097492 Poecilia formosa 68.68 0.00e+00 1372.00
IUUC-Pab-098192 Pongo abelii 99.32 0.00e+00 1960.00
IUUC-Pop-099733 Populus trichocarpa 32.95 8.00e-22 99.00
IUUC-Pca-101013 Procavia capensis 82.51 0.00e+00 1345.00
IUUC-Pva-103017 Pteropus vampyrus 96.19 0.00e+00 1640.00
IUUC-Rno-105357 Rattus norvegicus 96.98 0.00e+00 1923.00
IUUC-Sha-107037 Sarcophilus harrisii 84.89 0.00e+00 1108.00
IUUC-Sly-110938 Solanum lycopersicum 33.73 1.00e-20 95.50
IUUC-Stu-112273 Solanum tuberosum 33.73 1.00e-20 95.50
IUUC-Ssc-115524 Sus scrofa 97.56 0.00e+00 1931.00
IUUC-Tgu-117412 Taeniopygia guttata 85.59 0.00e+00 1764.00
IUUC-Tru-118635 Takifugu rubripes 70.49 0.00e+00 1407.00
IUUC-Tca-121687 Theobroma cacao 36.67 1.00e-21 98.60
IUUC-Ttr-128513 Tursiops truncatus 84.62 0.00e+00 1373.00
IUUC-Vvi-131740 Vitis vinifera 31.46 6.00e-20 92.80
IUUC-Xtr-132590 Xenopus tropicalis 75.34 0.00e+00 1551.00
Created Date 25-Jun-2017

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