iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044508

UUCD1 version

UUC-GoG-00805

Ensembl Protein ID

ENSGGOP00000021189.1

UniProt Accession

G3RZE6; G3RZE6_GORGO

Protein Name

Uncharacterized protein

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000005854.2	ENSGGOT00000027443.1	ENSGGOP00000021189.1
ENSGGOG00000005854.2	ENSGGOT00000005884.2	ENSGGOP00000005734.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.20e-07	29.8	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTCTGC TAAACTGTGA AAACAGCTGT GGATCCAGCC AGTCTGAAAG TGACTGCTGT 60
GTGGCCATGG CCAGCTCCTG TAGCGCTGCA ACAAAAGATG ATAGTGTGGG TGGAACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	84.71	0.00e+00	871.00
IUUC-Apl-004062	Anas platyrhynchos	68.11	0.00e+00	749.00
IUUC-Aca-004636	Anolis carolinensis	66.67	0.00e+00	701.00
IUUC-Ame-011682	Astyanax mexicanus	51.25	2.00e-158	551.00
IUUC-Bta-012692	Bos taurus	82.90	0.00e+00	881.00
IUUC-Cja-019426	Callithrix jacchus	88.57	0.00e+00	908.00
IUUC-Cfa-020948	Canis familiaris	83.10	0.00e+00	759.00
IUUC-Cpo-021378	Cavia porcellus	82.94	0.00e+00	864.00
IUUC-Csa-024045	Chlorocebus sabaeus	90.84	0.00e+00	941.00
IUUC-Cho-024973	Choloepus hoffmanni	64.03	3.00e-85	309.00
IUUC-Csv-026300	Ciona savignyi	37.00	8.00e-37	146.00
IUUC-Dre-027557	Danio rerio	54.84	5.00e-162	564.00
IUUC-Dno-030032	Dasypus novemcinctus	74.47	2.00e-118	418.00
IUUC-Dor-030790	Dipodomys ordii	85.88	0.00e+00	889.00
IUUC-Dme-031921	Drosophila melanogaster	28.00	4.00e-24	105.00
IUUC-Ete-032952	Echinops telfairi	89.06	6.00e-171	593.00
IUUC-Eca-033924	Equus caballus	79.45	0.00e+00	787.00
IUUC-Eeu-034734	Erinaceus europaeus	80.99	0.00e+00	805.00
IUUC-Fca-036222	Felis catus	81.90	0.00e+00	847.00
IUUC-Fal-036834	Ficedula albicollis	68.92	0.00e+00	662.00
IUUC-Gmo-039061	Gadus morhua	53.00	9.00e-76	277.00
IUUC-Ggr-040084	Gaeumannomyces graminis	26.67	3.00e-11	63.50
IUUC-Gga-040599	Gallus gallus	68.67	0.00e+00	759.00
IUUC-Gac-041977	Gasterosteus aculeatus	53.70	3.00e-150	525.00
IUUC-Hsa-046349	Homo sapiens	91.03	0.00e+00	976.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	85.71	0.00e+00	903.00
IUUC-Lch-049821	Latimeria chalumnae	64.12	0.00e+00	697.00
IUUC-Loc-051995	Lepisosteus oculatus	57.71	8.00e-172	596.00
IUUC-Laf-054115	Loxodonta africana	79.56	0.00e+00	844.00
IUUC-Mcc-055298	Macaca mulatta	90.65	0.00e+00	937.00
IUUC-Mpo-057517	Magnaporthe poae	27.15	1.00e-11	65.10
IUUC-Mga-059340	Meleagris gallopavo	68.49	0.00e+00	735.00
IUUC-Mmr-061063	Microcebus murinus	85.05	0.00e+00	869.00
IUUC-Mdo-062075	Monodelphis domestica	75.87	0.00e+00	837.00
IUUC-Mmu-063780	Mus musculus	83.27	0.00e+00	829.00
IUUC-Mpu-065748	Mustela putorius furo	83.24	0.00e+00	872.00
IUUC-Mlu-067888	Myotis lucifugus	83.15	0.00e+00	864.00
IUUC-Nle-069234	Nomascus leucogenys	91.22	0.00e+00	946.00
IUUC-Opr-070393	Ochotona princeps	97.18	1.00e-123	436.00
IUUC-Ont-072459	Oreochromis niloticus	51.58	1.00e-155	542.00
IUUC-Oan-073578	Ornithorhynchus anatinus	77.66	0.00e+00	833.00
IUUC-Ocu-074201	Oryctolagus cuniculus	85.08	0.00e+00	883.00
IUUC-Ola-087319	Oryzias latipes	54.79	3.00e-73	269.00
IUUC-Olu-087748	Ostreococcus lucimarinus	21.51	1.00e-07	50.80
IUUC-Oga-087936	Otolemur garnettii	84.04	0.00e+00	872.00
IUUC-Oar-089379	Ovis aries	82.72	0.00e+00	888.00
IUUC-Ptr-090758	Pan troglodytes	91.41	0.00e+00	944.00
IUUC-Pan-092590	Papio anubis	90.84	0.00e+00	939.00
IUUC-Psi-093948	Pelodiscus sinensis	67.94	0.00e+00	738.00
IUUC-Pma-094434	Petromyzon marinus	47.69	1.00e-64	240.00
IUUC-Pfo-096912	Poecilia formosa	49.39	5.00e-148	517.00
IUUC-Pab-097651	Pongo abelii	91.41	0.00e+00	945.00
IUUC-Pca-100958	Procavia capensis	83.06	0.00e+00	632.00
IUUC-Pva-103247	Pteropus vampyrus	79.53	4.00e-104	371.00
IUUC-Rno-104994	Rattus norvegicus	82.33	0.00e+00	852.00
IUUC-Sha-106494	Sarcophilus harrisii	78.80	0.00e+00	857.00
IUUC-Sar-113375	Sorex araneus	82.83	0.00e+00	846.00
IUUC-Ssc-115417	Sus scrofa	82.87	0.00e+00	878.00
IUUC-Tgu-117232	Taeniopygia guttata	68.67	0.00e+00	719.00
IUUC-Tru-118321	Takifugu rubripes	50.73	4.00e-148	518.00
IUUC-Tni-120475	Tetraodon nigroviridis	53.02	2.00e-147	515.00
IUUC-Tbe-127719	Tupaia belangeri	83.06	1.00e-176	612.00
IUUC-Ttr-129264	Tursiops truncatus	77.25	4.00e-100	358.00
IUUC-Vpa-130244	Vicugna pacos	78.04	2.00e-105	376.00
IUUC-Xtr-131948	Xenopus tropicalis	61.92	0.00e+00	687.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence