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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064093
Ensembl Protein ID ENSMUSP00000121519.1
UniProt Accession Q8C0D7; Q8C1S7; Q8K3Q5; Q8K3Q6; Q8K3Q7; Q9D7F9; ING4_MOUSE
Genbank Protein ID AAK63168.1; AAK63169.1; AAK64509.1; BAC25009.1; BAB26183.1; BAC27489.1; BAC34304.1; AAH09127.1
Protein Name Inhibitor of growth protein 4; p29ING4
Genbank Nucleotide ID AY035880; AY035881; AY036107; AK002821; AK009267; AK031633; AK050522; BC009127
Gene Name Ing4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030330.15 ENSMUST00000140131.7 ENSMUSP00000121519.1
ENSMUSG00000030330.15 ENSMUST00000032480.13 ENSMUSP00000032480.7
ENSMUSG00000030330.15 ENSMUST00000112417.8 ENSMUSP00000108036.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.60e-09 38.9 197 244
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 197  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 244
           69*.*******99..********999***********...899996.******97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890).
 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890).
Protein Sequence
(Fasta)
MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 60
KLALLRQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120
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Protein Fasta Sequence


>IUUC-Mmu-064093|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
AGTTCAGGTA CGGAAAAGGT GTAATCCAAG AATGGTTACA GCGCCTGTCG TGTATCAGTC 60
ACTTCCGGGG AAGATCGGAA GTTGCTTTGT TTTGCTTCAA GATGGCTGCT GGGATGTATT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064093|E3,PHD|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0164--Citrullination
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF12998--ING
SMART

SM01408--ING
SM00249--PHD
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0006473--P:protein acetylation
KEGG mmu:28019
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001338 Ailuropoda melanoleuca 98.80 6.00e-127 446.00
IUUC-Apl-004097 Anas platyrhynchos 92.74 3.00e-118 417.00
IUUC-Aca-004593 Anolis carolinensis 95.98 5.00e-124 436.00
IUUC-Ame-011133 Astyanax mexicanus 80.48 9.00e-117 412.00
IUUC-Bta-012699 Bos taurus 98.39 4.00e-127 446.00
IUUC-Bdi-014504 Brachypodium distachyon 35.86 4.00e-39 154.00
IUUC-Bol-015245 Brassica oleracea 31.33 6.00e-30 124.00
IUUC-Bra-017027 Brassica rapa 31.73 1.00e-30 125.00
IUUC-Cja-019988 Callithrix jacchus 99.20 2.00e-120 424.00
IUUC-Cfa-021282 Canis familiaris 99.20 2.00e-120 424.00
IUUC-Cpo-022011 Cavia porcellus 100.00 4.00e-131 460.00
IUUC-Cre-022920 Chlamydomonas reinhardtii 31.23 9.00e-29 120.00
IUUC-Csa-023203 Chlorocebus sabaeus 99.20 2.00e-120 424.00
IUUC-Cin-025479 Ciona intestinalis 61.34 4.00e-79 287.00
IUUC-Csv-026288 Ciona savignyi 55.06 1.00e-74 273.00
IUUC-Dre-028264 Danio rerio 80.08 4.00e-115 407.00
IUUC-Dno-029766 Dasypus novemcinctus 96.37 7.00e-114 402.00
IUUC-Dor-031136 Dipodomys ordii 85.17 2.00e-99 354.00
IUUC-Dme-032200 Drosophila melanogaster 74.19 2.00e-40 159.00
IUUC-Eca-033565 Equus caballus 99.20 2.00e-130 457.00
IUUC-Eeu-034948 Erinaceus europaeus 78.95 7.00e-99 353.00
IUUC-Fca-036368 Felis catus 99.60 6.00e-121 426.00
IUUC-Fal-037120 Ficedula albicollis 92.34 6.00e-117 413.00
IUUC-Gmo-038982 Gadus morhua 81.60 4.00e-116 410.00
IUUC-Gga-040771 Gallus gallus 95.98 5.00e-124 436.00
IUUC-Gac-042184 Gasterosteus aculeatus 80.89 3.00e-112 397.00
IUUC-Gma-044339 Glycine max 29.76 4.00e-34 137.00
IUUC-Ggo-045559 Gorilla gorilla 99.20 2.00e-120 424.00
IUUC-Hsa-046852 Homo sapiens 99.20 2.00e-120 424.00
IUUC-Hvu-047046 Hordeum vulgare 35.71 4.00e-38 151.00
IUUC-Itr-047978 Ictidomys tridecemlineatus 99.60 1.00e-130 458.00
IUUC-Kpa-049229 Komagataella pastoris 59.18 1.00e-16 79.30
IUUC-Lpe-050822 Leersia perrieri 34.66 6.00e-38 150.00
IUUC-Laf-054057 Loxodonta africana 99.60 6.00e-121 426.00
IUUC-Mcc-055212 Macaca mulatta 92.83 2.00e-114 405.00
IUUC-Meu-056511 Macropus eugenii 98.31 3.00e-121 427.00
IUUC-Mtr-058288 Medicago truncatula 31.85 8.00e-33 133.00
IUUC-Mga-059967 Meleagris gallopavo 93.52 9.00e-118 416.00
IUUC-Mmr-060843 Microcebus murinus 97.59 7.00e-127 446.00
IUUC-Mdo-062357 Monodelphis domestica 98.39 7.00e-130 456.00
IUUC-Mpu-066923 Mustela putorius furo 87.95 7.00e-98 349.00
IUUC-Mlu-067754 Myotis lucifugus 91.27 2.00e-118 417.00
IUUC-Nle-069062 Nomascus leucogenys 99.20 2.00e-120 424.00
IUUC-Opr-070207 Ochotona princeps 92.37 1.00e-111 395.00
IUUC-Ont-072446 Oreochromis niloticus 82.00 9.00e-115 405.00
IUUC-Ocu-074235 Oryctolagus cuniculus 99.20 2.00e-120 424.00
IUUC-Ogl-077118 Oryza glaberrima 33.33 3.00e-36 145.00
IUUC-Ome-081291 Oryza meridionalis 33.73 8.00e-37 147.00
IUUC-Opu-084171 Oryza punctata 34.13 7.00e-36 144.00
IUUC-Osa-085563 Oryza sativa 33.73 8.00e-37 147.00
IUUC-Ola-086429 Oryzias latipes 77.20 6.00e-106 376.00
IUUC-Olu-087851 Ostreococcus lucimarinus 33.95 5.00e-20 90.90
IUUC-Oga-089123 Otolemur garnettii 99.60 6.00e-121 426.00
IUUC-Oar-089524 Ovis aries 98.39 4.00e-127 446.00
IUUC-Ptr-090908 Pan troglodytes 98.80 6.00e-120 422.00
IUUC-Pan-092837 Papio anubis 98.39 2.00e-126 444.00
IUUC-Psi-093828 Pelodiscus sinensis 95.71 2.00e-113 401.00
IUUC-Ppa-096009 Physcomitrella patens 33.59 2.00e-34 139.00
IUUC-Pfo-096617 Poecilia formosa 81.60 8.00e-115 405.00
IUUC-Pab-097978 Pongo abelii 98.73 7.00e-110 389.00
IUUC-Pop-099415 Populus trichocarpa 73.68 2.00e-26 112.00
IUUC-Pca-100475 Procavia capensis 66.67 3.00e-85 308.00
IUUC-Pva-102325 Pteropus vampyrus 99.20 2.00e-130 457.00
IUUC-Rno-105178 Rattus norvegicus 98.39 4.00e-137 480.00
IUUC-Sha-106773 Sarcophilus harrisii 98.39 7.00e-130 456.00
IUUC-Sit-109827 Setaria italica 34.26 2.00e-36 145.00
IUUC-Sly-111750 Solanum lycopersicum 33.47 1.00e-35 142.00
IUUC-Stu-112250 Solanum tuberosum 33.47 1.00e-35 142.00
IUUC-Sbi-114826 Sorghum bicolor 35.86 3.00e-37 148.00
IUUC-Sre-115124 Sporisorium reilianum 58.21 3.00e-22 100.00
IUUC-Ssc-115797 Sus scrofa 92.68 4.00e-105 374.00
IUUC-Tgu-117270 Taeniopygia guttata 95.98 5.00e-124 436.00
IUUC-Tru-118253 Takifugu rubripes 80.88 3.00e-115 407.00
IUUC-Tae-123043 Triticum aestivum 35.14 2.00e-37 149.00
IUUC-Tbe-127558 Tupaia belangeri 98.80 6.00e-127 446.00
IUUC-Ttr-128300 Tursiops truncatus 100.00 1.00e-65 242.00
IUUC-Uma-129581 Ustilago maydis 57.63 3.00e-21 97.10
Created Date 25-Jun-2017

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