iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000030024.2	ENSGALT00000065051.1	ENSGALP00000046353.1
ENSGALG00000030024.2	ENSGALT00000054787.1	ENSGALP00000049379.1
ENSGALG00000030024.2	ENSGALT00000061318.1	ENSGALP00000046641.1
ENSGALG00000030024.2	ENSGALT00000087053.1	ENSGALP00000059175.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-117	393.3	288	932
ULD/UDP/UBQ/UBQ_Other	2.50e-09	37.3	147	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS++QcLsn+p+l+e++l+ k++e+ln +np ++ ge++ks+++l++++w++k ++v+pr+++++++++a++fsgy+
   Q: 288  CGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNdKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKYSYVTPRAFKTQVGRFAPQFSGYQ 376
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ ++kp+ +++++d   ++d+     a+e++ k+n+s+i+d+F+g +ks+++c+ec+++s++++pf++l
   Q: 377  QQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKvvaeeAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYL 463
           ******************************9999..5555555777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+e+ +e                                                                            
   Q: 464  TLPLPMKKERTLEvflvrmdplakpmqykvvvpkignildlctalsalsgvaadkmivtdiynhrfhrifamdenlssimerddiyvfe 552
           *********9999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 553  iainrtedteqviipvclrekcrhtsyshsgsslfgqpfliavprnntedklynllllrmcryvktctetddsegslrcckehgingng 641
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 642  pngiheegspsemetdeqddessqdqelpsenensqsedsvggdndsenglctedtckgqpltghkkrlftfqfnnlgntdinyikddt 730
           ***************************************************************************************** PP
   S: 186  .......................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                  +l+dc+e ft++e+l  e+ +yc++ck++q+a+k
   Q: 731  rhirfddrqprldersflaldwdpelkkryfddsaaedfekhesveykppkkpfvKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATK 819
           ***************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.W 306
           kl+l++l ++L++hLkRfs+s+  ++r k+++ v fp++ Ld+s+f+++p+ +   +++Y+Liav +H+G++++GHY+a++kn++++ W
   Q: 820  KLDLWSLAQILVVHLKRFSYSR--YMRDKLDTLVGFPINdLDMSEFLINPNAG---PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGkW 903
           ******************9977..6999*********************9988...8**************************65555* PP
   S: 307  llfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++fdDs+V+   e+++++   + aYvlfY+r+
   Q: 904  YYFDDSSVSIACEDQIVS---KAAYVLFYQRQ 932
           ******************...*********96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
           + t++++++dt+ ++ ++i+k ++ip + + rL++k      ++L ++d t++d gl++g+++++++k+++
   Q: 147  VVTRRFSKADTIDTIEKEIRKIFNIPgEKETRLWNKymsntFEPLnKPDSTIQDAGLYQGQVLVIEQKNED 217
           77899*********************888*****998875544569*********************9986 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAEGGAADLE TQRTDVAALL KTALRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LKDGDSQSLK EHLIDELDYI LLPTEGWNRL VSWYTLMEGQ EPIARKVVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCTACC GCTGCCGCCG CTGCTGCCGG GGGGAGAAGA TGGCGGAGGG AGGCGCGGCG 60
GATCTGGAGA CCCAGCGCAC GGACGTGGCG GCGCTGCTCA AAACCGCCCT CCGCAAGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001852	Ailuropoda melanoleuca	92.99	0.00e+00	1803.00
IUUC-Apl-003249	Anas platyrhynchos	98.53	0.00e+00	1773.00
IUUC-Aca-004261	Anolis carolinensis	94.15	0.00e+00	1727.00
IUUC-Aly-005644	Arabidopsis lyrata	36.60	9.00e-139	487.00
IUUC-Acl-008284	Aspergillus clavatus	38.24	3.00e-56	214.00
IUUC-Ame-010757	Astyanax mexicanus	78.26	0.00e+00	1269.00
IUUC-Bta-013128	Bos taurus	91.75	0.00e+00	1777.00
IUUC-Cel-018203	Caenorhabditis elegans	59.41	7.00e-70	258.00
IUUC-Cja-019222	Callithrix jacchus	93.39	0.00e+00	1811.00
IUUC-Cfa-020035	Canis familiaris	92.99	0.00e+00	1801.00
IUUC-Cpo-022071	Cavia porcellus	93.17	0.00e+00	1729.00
IUUC-Csa-023882	Chlorocebus sabaeus	93.69	0.00e+00	1816.00
IUUC-Cho-024875	Choloepus hoffmanni	96.27	9.00e-140	491.00
IUUC-Csv-026109	Ciona savignyi	43.64	0.00e+00	695.00
IUUC-Cme-027338	Cyanidioschyzon merolae	56.36	3.00e-68	253.00
IUUC-Dre-027869	Danio rerio	57.76	0.00e+00	1079.00
IUUC-Dno-029025	Dasypus novemcinctus	89.25	0.00e+00	1700.00
IUUC-Dor-030956	Dipodomys ordii	84.85	0.00e+00	1546.00
IUUC-Eca-034340	Equus caballus	93.81	0.00e+00	1757.00
IUUC-Eeu-034488	Erinaceus europaeus	83.81	0.00e+00	1202.00
IUUC-Fca-035552	Felis catus	91.24	0.00e+00	1767.00
IUUC-Fal-036618	Ficedula albicollis	98.11	0.00e+00	1760.00
IUUC-Gac-041679	Gasterosteus aculeatus	77.03	0.00e+00	1466.00
IUUC-Gma-043368	Glycine max	40.56	1.00e-118	421.00
IUUC-Ggo-045002	Gorilla gorilla	93.82	0.00e+00	1753.00
IUUC-Hsa-046052	Homo sapiens	93.59	0.00e+00	1815.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	91.46	0.00e+00	1774.00
IUUC-Kpa-049332	Komagataella pastoris	32.60	1.00e-71	265.00
IUUC-Lch-050107	Latimeria chalumnae	86.88	0.00e+00	1750.00
IUUC-Loc-052105	Lepisosteus oculatus	83.06	0.00e+00	1516.00
IUUC-Lma-052981	Leptosphaeria maculans	34.33	4.00e-66	247.00
IUUC-Laf-053645	Loxodonta africana	92.68	0.00e+00	1798.00
IUUC-Mcc-055586	Macaca mulatta	93.59	0.00e+00	1815.00
IUUC-Meu-056764	Macropus eugenii	87.95	0.00e+00	977.00
IUUC-Mla-058848	Melampsora laricipopulina	31.32	2.00e-71	265.00
IUUC-Mga-060162	Meleagris gallopavo	99.49	0.00e+00	1850.00
IUUC-Mvi-060324	Microbotryum violaceum	41.49	5.00e-71	263.00
IUUC-Mmr-061105	Microcebus murinus	93.59	0.00e+00	1814.00
IUUC-Mdo-062107	Monodelphis domestica	93.59	0.00e+00	1800.00
IUUC-Mmu-063662	Mus musculus	92.27	0.00e+00	1794.00
IUUC-Mac-064956	Musa acuminata	40.36	2.00e-110	393.00
IUUC-Mpu-065868	Mustela putorius furo	91.13	0.00e+00	1795.00
IUUC-Mlu-068000	Myotis lucifugus	87.17	0.00e+00	1607.00
IUUC-Nfi-068330	Neosartorya fischeri	36.72	5.00e-57	216.00
IUUC-Nle-069874	Nomascus leucogenys	93.58	0.00e+00	1791.00
IUUC-Opr-071212	Ochotona princeps	88.04	0.00e+00	1697.00
IUUC-Ont-071834	Oreochromis niloticus	78.40	0.00e+00	1459.00
IUUC-Ocu-074573	Oryctolagus cuniculus	93.79	0.00e+00	1819.00
IUUC-Oga-089022	Otolemur garnettii	91.55	0.00e+00	1773.00
IUUC-Oar-089767	Ovis aries	92.98	0.00e+00	1803.00
IUUC-Ptr-091319	Pan troglodytes	92.26	0.00e+00	1786.00
IUUC-Pan-091968	Papio anubis	93.69	0.00e+00	1816.00
IUUC-Psi-093849	Pelodiscus sinensis	95.48	0.00e+00	1721.00
IUUC-Pma-094533	Petromyzon marinus	59.45	0.00e+00	1101.00
IUUC-Pno-094890	Phaeosphaeria nodorum	32.48	9.00e-60	226.00
IUUC-Pfo-097110	Poecilia formosa	77.63	0.00e+00	1458.00
IUUC-Pab-098664	Pongo abelii	93.69	0.00e+00	1816.00
IUUC-Pca-100359	Procavia capensis	75.90	0.00e+00	1270.00
IUUC-Pva-102394	Pteropus vampyrus	91.86	0.00e+00	1768.00
IUUC-Pgr-103546	Puccinia graminis	29.58	6.00e-68	253.00
IUUC-Ptt-103847	Puccinia triticina	37.88	3.00e-60	227.00
IUUC-Pte-104102	Pyrenophora teres	36.07	4.00e-56	214.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	39.56	2.00e-55	211.00
IUUC-Rno-105383	Rattus norvegicus	91.04	0.00e+00	1774.00
IUUC-Sce-106170	Saccharomyces cerevisiae	37.53	2.00e-61	231.00
IUUC-Sha-107393	Sarcophilus harrisii	93.69	0.00e+00	1806.00
IUUC-Sja-107752	Schizosaccharomyces japonicus	35.80	3.00e-81	296.00
IUUC-Ssl-108461	Sclerotinia sclerotiorum	31.11	4.00e-14	73.20
IUUC-Smo-109356	Selaginella moellendorffii	47.32	3.00e-80	292.00
IUUC-Sit-109948	Setaria italica	37.14	5.00e-143	501.00
IUUC-Sly-111726	Solanum lycopersicum	39.74	2.00e-94	340.00
IUUC-Sar-113498	Sorex araneus	92.68	0.00e+00	1794.00
IUUC-Ssc-115285	Sus scrofa	93.29	0.00e+00	1805.00
IUUC-Tgu-116529	Taeniopygia guttata	98.27	0.00e+00	1828.00
IUUC-Tru-118298	Takifugu rubripes	76.86	0.00e+00	1481.00
IUUC-Tsy-119117	Tarsius syrichta	84.66	0.00e+00	1086.00
IUUC-Tni-120093	Tetraodon nigroviridis	74.43	0.00e+00	1399.00
IUUC-Tme-127062	Tuber melanosporum	31.54	2.00e-79	291.00
IUUC-Tbe-127672	Tupaia belangeri	84.85	0.00e+00	1188.00
IUUC-Ttr-128441	Tursiops truncatus	89.09	0.00e+00	1113.00
IUUC-Vpa-130469	Vicugna pacos	93.39	0.00e+00	1740.00
IUUC-Xtr-132729	Xenopus tropicalis	82.60	0.00e+00	1615.00
IUUC-Xma-133550	Xiphophorus maculatus	77.63	0.00e+00	1454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence