iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048412

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01058687

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000015018.2	ENSSTOT00000015022.2	ENSSTOP00000013460.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	7.80e-06	26.0	9	53
E3 adaptor/Cullin RING/DCX/DWD	7.00e-14	51.4	328	361
UBD/Beta-Prp	9.50e-44	149.7	98	401

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
              +lp+e+ ++i+++ld++el+r+a+v+++w+ +a+++ lw ++
   Q: 9    FDVQLPYELAINIFQYLDRKELGRCAQVSKTWKVIAEDEVLWYRL 53
           5679*****************************999999999765 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           + tc+++  s  +l+vsG+ D  +++ Dlrt++ 
   Q: 328  DFTCVNLrdSPpNLMVSGNMDRRVRIHDLRTDKI 361
           569****983359******************975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e e         v+ v+++++  + v + eD+++++wdl+t
   Q: 98   ELEHIPDAVLCDVHS--HDGVVIAGYTSGEVRVWDTRTWDYVAPFLESEYEedepgmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 182
           567778999998888..9***********************5555444444455569999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ ++++++  e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 183  GKYPIHHFEHDARIQALALSKDDATVATASAFDVVMLYPNEEGYWQIAAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDS 270
           **9999999*********************************************************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr++
   Q: 271  ARTLHYVYGQPVTCLDVSANQvafgvKSLGWVYEGNKILVYSLEAERCLSKLGNTLGDFTCVNLRdSPPNLMVSGNMDRRVRIHDLRTD 359
           ****999********************************************************9978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++n++
   Q: 360  KIALSLSAHQLGVSAVQM---DDWKVVSGGEEGLVSVWDYRMNQK 401
           **********99999999...********************9875 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

NEMDDVPFFD VQLPYELAIN IFQYLDRKEL GRCAQVSKTW KVIAEDEVLW YRLCQQEGHL 60
PESSISDYSC WKLIFQECRA KEHMLRTNWK NRKGAVSELE HIPDAVLCDV HSHDGVVIAG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATAGAGTA CTTCCCTTCT GGGAAACAGC CTTATCTCTC TTGTTACCAC CTAAGAGTAT 60
CTCTGGTAAC TTAAAAGGCC TGAAGATGTG AGTTATTTTC ATATTTCAGA ATTTTAAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	94.06	0.00e+00	971.00
IUUC-Apl-003239	Anas platyrhynchos	65.86	0.00e+00	701.00
IUUC-Aca-004756	Anolis carolinensis	62.07	9.00e-142	496.00
IUUC-Ame-011198	Astyanax mexicanus	53.98	8.00e-53	200.00
IUUC-Bta-012430	Bos taurus	56.32	4.00e-148	518.00
IUUC-Bra-016832	Brassica rapa	34.85	3.00e-05	42.40
IUUC-Cja-019131	Callithrix jacchus	84.55	0.00e+00	865.00
IUUC-Cfa-021022	Canis familiaris	94.06	0.00e+00	970.00
IUUC-Cpo-021898	Cavia porcellus	93.09	0.00e+00	967.00
IUUC-Csa-023452	Chlorocebus sabaeus	88.41	0.00e+00	904.00
IUUC-Cho-024759	Choloepus hoffmanni	78.86	0.00e+00	797.00
IUUC-Dre-028123	Danio rerio	49.80	6.00e-146	510.00
IUUC-Dno-029045	Dasypus novemcinctus	93.87	0.00e+00	902.00
IUUC-Dor-030433	Dipodomys ordii	91.20	0.00e+00	786.00
IUUC-Ete-032465	Echinops telfairi	90.42	0.00e+00	787.00
IUUC-Eca-034134	Equus caballus	93.70	0.00e+00	973.00
IUUC-Eeu-035047	Erinaceus europaeus	82.48	0.00e+00	838.00
IUUC-Fca-036574	Felis catus	92.45	0.00e+00	951.00
IUUC-Fal-037665	Ficedula albicollis	62.83	0.00e+00	633.00
IUUC-Gmo-039137	Gadus morhua	46.33	3.00e-62	232.00
IUUC-Gga-040711	Gallus gallus	64.44	0.00e+00	679.00
IUUC-Gac-041675	Gasterosteus aculeatus	53.16	1.00e-55	208.00
IUUC-Ggo-045331	Gorilla gorilla	87.60	0.00e+00	898.00
IUUC-Hsa-046240	Homo sapiens	88.21	0.00e+00	908.00
IUUC-Loc-052631	Lepisosteus oculatus	55.38	2.00e-168	585.00
IUUC-Laf-054127	Loxodonta africana	81.82	1.00e-64	237.00
IUUC-Mcc-055083	Macaca mulatta	88.62	0.00e+00	910.00
IUUC-Mga-060113	Meleagris gallopavo	64.44	0.00e+00	678.00
IUUC-Mmr-061780	Microcebus murinus	93.50	0.00e+00	965.00
IUUC-Mdo-063066	Monodelphis domestica	68.22	0.00e+00	729.00
IUUC-Mmu-063524	Mus musculus	88.21	0.00e+00	889.00
IUUC-Mpu-066913	Mustela putorius furo	93.65	0.00e+00	960.00
IUUC-Mlu-067924	Myotis lucifugus	91.87	0.00e+00	923.00
IUUC-Nle-069558	Nomascus leucogenys	88.22	0.00e+00	858.00
IUUC-Opr-070506	Ochotona princeps	92.26	0.00e+00	954.00
IUUC-Ont-071514	Oreochromis niloticus	48.59	8.00e-144	503.00
IUUC-Ocu-074477	Oryctolagus cuniculus	91.55	0.00e+00	939.00
IUUC-Ola-087416	Oryzias latipes	49.30	6.00e-144	504.00
IUUC-Oga-088643	Otolemur garnettii	93.50	0.00e+00	971.00
IUUC-Oar-090172	Ovis aries	91.67	0.00e+00	954.00
IUUC-Ptr-090870	Pan troglodytes	88.41	0.00e+00	910.00
IUUC-Pan-092017	Papio anubis	88.01	0.00e+00	900.00
IUUC-Psi-093794	Pelodiscus sinensis	66.06	0.00e+00	694.00
IUUC-Pfo-096192	Poecilia formosa	50.60	1.00e-147	516.00
IUUC-Pab-097882	Pongo abelii	87.60	0.00e+00	895.00
IUUC-Pca-100902	Procavia capensis	92.02	3.00e-133	468.00
IUUC-Pva-103139	Pteropus vampyrus	93.70	0.00e+00	973.00
IUUC-Rno-105798	Rattus norvegicus	87.40	0.00e+00	909.00
IUUC-Sha-106576	Sarcophilus harrisii	67.83	0.00e+00	713.00
IUUC-Ssc-115923	Sus scrofa	85.92	0.00e+00	884.00
IUUC-Tgu-116667	Taeniopygia guttata	58.67	8.00e-124	436.00
IUUC-Tru-118323	Takifugu rubripes	47.39	1.00e-139	489.00
IUUC-Tsy-118818	Tarsius syrichta	77.95	1.00e-112	399.00
IUUC-Tni-120438	Tetraodon nigroviridis	47.19	3.00e-133	468.00
IUUC-Tbe-127784	Tupaia belangeri	94.17	7.00e-114	403.00
IUUC-Ttr-128288	Tursiops truncatus	83.10	0.00e+00	843.00
IUUC-Vpa-130307	Vicugna pacos	88.74	0.00e+00	816.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence