iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037589

Ensembl Protein ID

ENSFALP00000009545.1

UniProt Accession

U3K3E1; U3K3E1_FICAL

Genbank Protein ID

ENSFALP00000009545

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000195

Gene Name

KDM2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000009151.1	ENSFALT00000009585.1	ENSFALP00000009545.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	5.50e-06	26.2	934	1022
E3 activity/RING/PHD	2.90e-14	52.7	629	694

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 56   rrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqka 141
           r +pr   r p + + pk+         p p +p p   p    d g  + ++ e+++ ++++l++++l+ + rvc++w++ + +k+
   Q: 934  RSAPRGIARPPPSLSPPKCIQMERHVIRPPPiSPPPDSLPL---DDGAAHVMQREVWMAVFSYLSHRDLCICMRVCKTWNRWCCDKR 1017
           66788888888888888876555555555541333444443...6677788899**************************5555599 PP
   S: 142  lwktv 146
           lw ++
   Q: 1018 LWTKI 1022
           *9986 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk +     v++elpn+  w+CpkC+++
   Q: 629  AVCLVCGEAGKEDtveeeEskfnlMLMECSICNEIIHPGCLKVKesdgvVNDELPNC--WECPKCNHA 694
           79*********9977766156889*********************************..*******85 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MKLSKKMEAK KDSGRRLRCI GRRRYDENED LSDVEEIVSI RSFNLEEKLK SKMYHGDFVH 60
AMDGKDFTFE YVQREALRVP LIFRNKDGLG IKMPDPDFTV RDVKLLVGSR RIVDVMDVNT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCCC CCCCCCCCAA AGTCCTGGTG 60
CAAAATTGCA AAACTTTAGC GAGCCCTGGA TGGCTTTTGT TTTGCCTCCT CCCCATTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	82.59	0.00e+00	2008.00
IUUC-Apl-003787	Anas platyrhynchos	96.02	0.00e+00	2169.00
IUUC-Aca-004247	Anolis carolinensis	79.10	0.00e+00	1834.00
IUUC-Aor-010233	Aspergillus oryzae	45.45	1.00e-63	238.00
IUUC-Ame-011463	Astyanax mexicanus	73.28	5.00e-169	588.00
IUUC-Bta-013531	Bos taurus	83.28	0.00e+00	2034.00
IUUC-Cel-018303	Caenorhabditis elegans	44.25	3.00e-85	310.00
IUUC-Cja-018876	Callithrix jacchus	79.58	0.00e+00	1884.00
IUUC-Cfa-020857	Canis familiaris	83.45	0.00e+00	2029.00
IUUC-Cpo-021967	Cavia porcellus	80.49	0.00e+00	1908.00
IUUC-Csa-023210	Chlorocebus sabaeus	82.20	0.00e+00	1977.00
IUUC-Cme-027118	Cyanidioschyzon merolae	36.03	5.00e-49	189.00
IUUC-Dre-028272	Danio rerio	64.76	0.00e+00	1551.00
IUUC-Dno-030034	Dasypus novemcinctus	82.35	0.00e+00	1967.00
IUUC-Dor-030736	Dipodomys ordii	71.64	0.00e+00	821.00
IUUC-Dse-031402	Dothistroma septosporum	42.25	1.00e-60	229.00
IUUC-Eca-034255	Equus caballus	83.57	0.00e+00	1952.00
IUUC-Eeu-035038	Erinaceus europaeus	82.46	0.00e+00	1012.00
IUUC-Fca-035786	Felis catus	83.27	0.00e+00	1952.00
IUUC-Gga-041103	Gallus gallus	98.00	0.00e+00	1281.00
IUUC-Gac-041304	Gasterosteus aculeatus	70.28	0.00e+00	1006.00
IUUC-Ggo-044522	Gorilla gorilla	73.62	0.00e+00	1651.00
IUUC-Hsa-045877	Homo sapiens	83.77	0.00e+00	2008.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	83.54	0.00e+00	1147.00
IUUC-Lch-049950	Latimeria chalumnae	83.94	0.00e+00	2038.00
IUUC-Loc-051972	Lepisosteus oculatus	71.65	0.00e+00	1130.00
IUUC-Lma-053190	Leptosphaeria maculans	42.01	5.00e-61	229.00
IUUC-Laf-053623	Loxodonta africana	81.93	0.00e+00	1954.00
IUUC-Mcc-054943	Macaca mulatta	82.69	0.00e+00	1990.00
IUUC-Meu-056259	Macropus eugenii	84.46	0.00e+00	1995.00
IUUC-Mga-059671	Meleagris gallopavo	94.03	0.00e+00	2215.00
IUUC-Mmr-061003	Microcebus murinus	82.80	0.00e+00	2013.00
IUUC-Mmu-063584	Mus musculus	82.21	0.00e+00	1993.00
IUUC-Mpu-066056	Mustela putorius furo	83.22	0.00e+00	2009.00
IUUC-Mlu-067850	Myotis lucifugus	82.44	0.00e+00	1992.00
IUUC-Nle-069837	Nomascus leucogenys	85.80	0.00e+00	1821.00
IUUC-Opr-070943	Ochotona princeps	80.05	0.00e+00	1866.00
IUUC-Ont-071663	Oreochromis niloticus	65.65	0.00e+00	1587.00
IUUC-Oan-072934	Ornithorhynchus anatinus	74.71	0.00e+00	1226.00
IUUC-Ocu-074706	Oryctolagus cuniculus	83.17	0.00e+00	2008.00
IUUC-Ola-086543	Oryzias latipes	66.12	0.00e+00	1029.00
IUUC-Oga-088671	Otolemur garnettii	77.04	0.00e+00	932.00
IUUC-Oar-089560	Ovis aries	79.23	0.00e+00	1946.00
IUUC-Ptr-090875	Pan troglodytes	83.70	0.00e+00	2021.00
IUUC-Pan-091788	Papio anubis	81.03	0.00e+00	1936.00
IUUC-Psi-093382	Pelodiscus sinensis	92.67	0.00e+00	2231.00
IUUC-Pma-094687	Petromyzon marinus	52.94	4.00e-95	342.00
IUUC-Pno-094984	Phaeosphaeria nodorum	45.28	7.00e-62	233.00
IUUC-Pfo-096272	Poecilia formosa	66.54	0.00e+00	1533.00
IUUC-Pab-097907	Pongo abelii	79.19	0.00e+00	1853.00
IUUC-Pca-100628	Procavia capensis	74.49	0.00e+00	1632.00
IUUC-Pva-102956	Pteropus vampyrus	75.88	0.00e+00	924.00
IUUC-Ptt-103859	Puccinia triticina	43.84	3.00e-73	269.00
IUUC-Pte-104241	Pyrenophora teres	42.42	5.00e-61	229.00
IUUC-Pyt-104741	Pyrenophora triticirepentis	42.42	3.00e-60	227.00
IUUC-Rno-105722	Rattus norvegicus	82.30	0.00e+00	1597.00
IUUC-Sha-106626	Sarcophilus harrisii	79.16	0.00e+00	1779.00
IUUC-Ssc-115918	Sus scrofa	81.01	0.00e+00	1526.00
IUUC-Tgu-117229	Taeniopygia guttata	84.74	0.00e+00	1987.00
IUUC-Tru-118638	Takifugu rubripes	68.64	0.00e+00	994.00
IUUC-Tme-127054	Tuber melanosporum	41.20	5.00e-52	199.00
IUUC-Tbe-127654	Tupaia belangeri	69.52	0.00e+00	1480.00
IUUC-Ttr-128821	Tursiops truncatus	76.68	0.00e+00	1792.00
IUUC-Xtr-131823	Xenopus tropicalis	75.29	0.00e+00	1799.00
IUUC-Xma-133305	Xiphophorus maculatus	66.54	0.00e+00	1017.00
IUUC-Yli-134626	Yarrowia lipolytica	42.01	6.00e-55	208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence