iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132012

Ensembl Protein ID

ENSXETP00000018010.3

UniProt Accession

F7CU97; F7CU97_XENTR

Genbank Protein ID

ENSXETP00000018010

Protein Name

Rho guanine nucleotide exchange factor 7

Genbank Nucleotide ID

AAMC01018080

Gene Name

arhgef7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000008213.3	ENSXETT00000018010.3	ENSXETP00000018010.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-14	53.7	164	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +v++ ++++ +n+deL+++kGd ++v     +++gW++g  + +gk G fP+n+v++++
   Q: 164  HMVVRAKFNFQQTNEDELSFNKGDLIHVT--RLEEGGWWEG--THSGKTGWFPSNYVREVK 220
           66899***********************7..99********..8**************997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQTSLKDGVV LCRLLERLLP GSIDKVYPEP 60
RTDTECLGNI REFLRGCSAF NLETFDANDL YQGQNFNKVL NSLVLLNKVT ADIGLGSDSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTCTG CAGAGCAAAC CGTAACATGG CTTATAACTC TCGGGGTGCT GGAGTCGCCC 60
AAGAAAACCA TCTCCGATCC GGAGGGCTTC CTGCAAACGT CCCTGAAGGA CGGGGTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	81.17	0.00e+00	1138.00
IUUC-Aca-004591	Anolis carolinensis	86.10	0.00e+00	1288.00
IUUC-Ame-010759	Astyanax mexicanus	73.73	0.00e+00	1218.00
IUUC-Bgr-012305	Blumeria graminis	39.39	7.00e-11	63.20
IUUC-Bta-013328	Bos taurus	83.89	0.00e+00	1345.00
IUUC-Cja-018742	Callithrix jacchus	84.68	0.00e+00	1045.00
IUUC-Cfa-020756	Canis familiaris	82.31	0.00e+00	988.00
IUUC-Cpo-021284	Cavia porcellus	83.31	0.00e+00	1251.00
IUUC-Csa-023162	Chlorocebus sabaeus	85.86	0.00e+00	1361.00
IUUC-Cho-024736	Choloepus hoffmanni	70.74	2.00e-165	575.00
IUUC-Cin-025535	Ciona intestinalis	38.53	5.00e-86	311.00
IUUC-Cne-026866	Cryptococcus neoformans	54.90	2.00e-12	68.90
IUUC-Dre-028646	Danio rerio	73.50	0.00e+00	1209.00
IUUC-Dno-029461	Dasypus novemcinctus	86.56	0.00e+00	1366.00
IUUC-Dor-030623	Dipodomys ordii	72.76	0.00e+00	897.00
IUUC-Dme-032219	Drosophila melanogaster	46.67	6.00e-98	352.00
IUUC-Ete-032236	Echinops telfairi	69.92	0.00e+00	686.00
IUUC-Eca-034137	Equus caballus	86.04	0.00e+00	1209.00
IUUC-Fca-035742	Felis catus	83.02	0.00e+00	961.00
IUUC-Fal-037205	Ficedula albicollis	86.97	0.00e+00	1088.00
IUUC-Gmo-039475	Gadus morhua	67.21	0.00e+00	1026.00
IUUC-Gga-040539	Gallus gallus	84.89	0.00e+00	877.00
IUUC-Gac-042615	Gasterosteus aculeatus	64.48	0.00e+00	946.00
IUUC-Ggo-044470	Gorilla gorilla	80.92	0.00e+00	1138.00
IUUC-Hsa-046398	Homo sapiens	82.85	0.00e+00	1181.00
IUUC-Loc-052146	Lepisosteus oculatus	82.97	0.00e+00	1316.00
IUUC-Laf-053891	Loxodonta africana	83.66	0.00e+00	1321.00
IUUC-Mcc-055483	Macaca mulatta	82.85	0.00e+00	1182.00
IUUC-Mga-059410	Meleagris gallopavo	85.34	0.00e+00	1218.00
IUUC-Mmr-060758	Microcebus murinus	84.97	0.00e+00	1136.00
IUUC-Mdo-061900	Monodelphis domestica	85.13	0.00e+00	1154.00
IUUC-Mmu-063849	Mus musculus	84.72	0.00e+00	1149.00
IUUC-Mpu-065876	Mustela putorius furo	82.22	0.00e+00	978.00
IUUC-Mlu-067970	Myotis lucifugus	86.03	0.00e+00	1210.00
IUUC-Nle-069685	Nomascus leucogenys	79.86	0.00e+00	887.00
IUUC-Opr-071132	Ochotona princeps	59.16	0.00e+00	650.00
IUUC-Ont-071815	Oreochromis niloticus	74.19	0.00e+00	1210.00
IUUC-Oan-073057	Ornithorhynchus anatinus	85.98	0.00e+00	1100.00
IUUC-Ola-086663	Oryzias latipes	72.35	0.00e+00	1044.00
IUUC-Oga-088103	Otolemur garnettii	84.97	0.00e+00	1160.00
IUUC-Ptr-091162	Pan troglodytes	81.78	0.00e+00	1081.00
IUUC-Pan-092093	Papio anubis	77.66	0.00e+00	1226.00
IUUC-Pma-094701	Petromyzon marinus	62.65	8.00e-133	466.00
IUUC-Pfo-096736	Poecilia formosa	67.09	0.00e+00	1045.00
IUUC-Pab-097641	Pongo abelii	84.15	0.00e+00	1138.00
IUUC-Pva-102819	Pteropus vampyrus	82.25	0.00e+00	1125.00
IUUC-Ptt-103822	Puccinia triticina	22.69	4.00e-08	53.90
IUUC-Rno-106099	Rattus norvegicus	84.82	0.00e+00	1303.00
IUUC-Sha-106845	Sarcophilus harrisii	84.04	0.00e+00	1004.00
IUUC-Sja-107728	Schizosaccharomyces japonicus	21.88	7.00e-10	59.30
IUUC-Ssc-116036	Sus scrofa	82.46	0.00e+00	970.00
IUUC-Tgu-117498	Taeniopygia guttata	83.66	0.00e+00	1293.00
IUUC-Tru-118278	Takifugu rubripes	71.02	0.00e+00	1036.00
IUUC-Tsy-118990	Tarsius syrichta	80.49	0.00e+00	827.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.01	0.00e+00	953.00
IUUC-Ttr-128922	Tursiops truncatus	78.80	0.00e+00	1002.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence