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Tag Content
UUCD2 ID IUUC-Mcc-054873
UUCD1 version UUC-MaM-00754
Ensembl Protein ID ENSMMUP00000008564.3
UniProt Accession G7MWZ8; F7H925; G7MWZ8_MACMU
Genbank Protein ID AFH31400.1; EHH27256.1
Protein Name E3 ubiquitin-protein ligase UBR1
Genbank Nucleotide ID JSUE03038141; CM001259
Gene Name UBR1; EGK_17415
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000006498.3 ENSMMUT00000009115.3 ENSMMUP00000008564.3
ENSMMUG00000006498.3 ENSMMUT00000009117.3 ENSMMUP00000008566.3
ENSMMUG00000006498.3 ENSMMUT00000062614.1 ENSMMUP00000046055.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/N-recognin/N-domain 2.90e-40 137.4 226 302
E3 activity/RING/RING 3.70e-08 34.8 1098 1201
E3 activity/N-recognin/UBR-box 3.50e-31 108.6 97 167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/N-recognin/N-domain
   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy+vLfNDE+Hsy++viyslq+Al++e++ea++++t+idkeGRravkaG+ya+c+eak++i+++se+++q+pL+Vev
   Q: 226  YYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEV 302
           9**************************************************************************97 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledf...............kd..............................gplvlpCgHvfhadClqkw............. 29
           C++C+e+                ++                              g+++++CgHv+ha C+qk+             
   Q: 1098 CILCQEEQevkiennamvlsacvQKstaltqhrgkpielsgetldplfmdpdlayGTYTGSCGHVMHAVCWQKYfeavqlssqqrih 1184
           78885544433333333333222002233333333333333333333333333337999**************************** PP
   S: 30   pglknssskefrCPlCr 46
           ++l +++s+e +CPlC+
   Q: 1185 VDLFDLESGEYLCPLCK 1201
           ****************7 PP
   

   E3 activity/N-recognin/UBR-box
   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCg+vfk+get+y+Cr+C++d+t+vlC++Cf+++vHk+H+yk+++s+gggfCdCGdteAw++g++C++++
   Q: 97   QLCGKVFKSGETTYSCRDCAIDPTCVLCMDCFQNSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHE 167
           68*******************************************************************96 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MADEEAGGAE RMEISAELPQ TPQRLACWWD QQVDFYTAFL HHLAQLVPEI YFAEMDPDLE 60
KQEQSVQMSI FTPLEWYLFG EDPDICLEKL KHSGAFQLCG KVFKSGETTY SCRDCAIDPT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-054873|E3,N-domain;E3,RING;E3,UBR-box|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTATGTTGCC CATCTCAAAC AATCCTCCCG CCTTGGCCTC CCAAAGTGCT AACATTACAG 60
GGGTGAGCCA TTGTGCTGGC TGAATGTCTG CTCTGTCACT TGGAAGCTGC ATGTCCCTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-054873|E3,N-domain;E3,RING;E3,UBR-box|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02617--ClpS
PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0000502--C:proteasome complex
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0032007--P:negative regulation of TOR signaling
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mcc:709238
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001354 Ailuropoda melanoleuca 95.04 0.00e+00 3347.00
IUUC-Apl-004160 Anas platyrhynchos 78.22 0.00e+00 2749.00
IUUC-Aca-004982 Anolis carolinensis 75.43 0.00e+00 2655.00
IUUC-Acl-008055 Aspergillus clavatus 23.20 1.00e-47 186.00
IUUC-Ate-010550 Aspergillus terreus 23.31 3.00e-47 185.00
IUUC-Ame-011231 Astyanax mexicanus 57.47 0.00e+00 1894.00
IUUC-Bgr-011999 Blumeria graminis 23.24 6.00e-46 181.00
IUUC-Bta-012347 Bos taurus 93.92 0.00e+00 3308.00
IUUC-Bci-013834 Botrytis cinerea 22.76 1.00e-40 163.00
IUUC-Cja-018911 Callithrix jacchus 92.98 0.00e+00 3235.00
IUUC-Cfa-020991 Canis familiaris 95.72 0.00e+00 3375.00
IUUC-Cpo-021448 Cavia porcellus 92.02 0.00e+00 3241.00
IUUC-Csa-024255 Chlorocebus sabaeus 99.73 0.00e+00 2880.00
IUUC-Cho-024550 Choloepus hoffmanni 73.60 0.00e+00 2485.00
IUUC-Dno-029427 Dasypus novemcinctus 93.29 0.00e+00 3193.00
IUUC-Dor-031073 Dipodomys ordii 79.35 0.00e+00 1380.00
IUUC-Ete-032318 Echinops telfairi 75.86 0.00e+00 1268.00
IUUC-Eca-033348 Equus caballus 94.63 0.00e+00 3088.00
IUUC-Eeu-034664 Erinaceus europaeus 85.26 0.00e+00 2984.00
IUUC-Fca-035604 Felis catus 89.22 0.00e+00 3051.00
IUUC-Fal-037333 Ficedula albicollis 78.23 0.00e+00 2709.00
IUUC-Fox-037984 Fusarium oxysporum 26.94 5.00e-40 160.00
IUUC-Gmo-039363 Gadus morhua 56.11 0.00e+00 1655.00
IUUC-Gga-040486 Gallus gallus 77.17 0.00e+00 2660.00
IUUC-Gac-041985 Gasterosteus aculeatus 56.70 0.00e+00 1731.00
IUUC-Ggo-044704 Gorilla gorilla 90.93 0.00e+00 2660.00
IUUC-Hsa-046753 Homo sapiens 98.34 0.00e+00 3456.00
IUUC-Itr-048410 Ictidomys tridecemlineatus 95.16 0.00e+00 3336.00
IUUC-Lch-049904 Latimeria chalumnae 61.92 0.00e+00 2124.00
IUUC-Loc-052624 Lepisosteus oculatus 60.90 0.00e+00 2053.00
IUUC-Laf-053857 Loxodonta africana 91.82 0.00e+00 3207.00
IUUC-Meu-056858 Macropus eugenii 66.50 0.00e+00 1031.00
IUUC-Mga-059917 Meleagris gallopavo 77.26 0.00e+00 2769.00
IUUC-Mmr-061128 Microcebus murinus 92.58 0.00e+00 3199.00
IUUC-Mdo-062306 Monodelphis domestica 80.78 0.00e+00 2828.00
IUUC-Mmu-063389 Mus musculus 92.26 0.00e+00 3270.00
IUUC-Mpu-065983 Mustela putorius furo 95.38 0.00e+00 3387.00
IUUC-Mlu-068013 Myotis lucifugus 91.79 0.00e+00 3243.00
IUUC-Nle-070031 Nomascus leucogenys 98.57 0.00e+00 3465.00
IUUC-Opr-070551 Ochotona princeps 71.08 0.00e+00 1379.00
IUUC-Ont-072035 Oreochromis niloticus 57.78 0.00e+00 1967.00
IUUC-Ocu-074930 Oryctolagus cuniculus 90.54 0.00e+00 3170.00
IUUC-Oba-075295 Oryza barthii 38.54 6.00e-14 74.30
IUUC-Ogu-078497 Oryza glumaepatula 38.54 5.00e-14 74.70
IUUC-Oin-079343 Oryza indica 38.54 7.00e-14 74.30
IUUC-Oni-083099 Oryza nivara 38.54 6.00e-14 74.30
IUUC-Oru-084471 Oryza rufipogon 38.54 6.00e-14 74.30
IUUC-Osa-086106 Oryza sativa 37.59 1.00e-13 72.00
IUUC-Ola-086683 Oryzias latipes 57.48 0.00e+00 1917.00
IUUC-Oga-088017 Otolemur garnettii 90.23 0.00e+00 3155.00
IUUC-Oar-089557 Ovis aries 93.43 0.00e+00 3303.00
IUUC-Ptr-091366 Pan troglodytes 97.14 0.00e+00 3436.00
IUUC-Pan-092184 Papio anubis 99.77 0.00e+00 3445.00
IUUC-Psi-093720 Pelodiscus sinensis 79.23 0.00e+00 2716.00
IUUC-Ppa-095780 Physcomitrella patens 21.74 9.00e-25 110.00
IUUC-Pfo-097124 Poecilia formosa 57.15 0.00e+00 1932.00
IUUC-Pab-098586 Pongo abelii 98.63 0.00e+00 3461.00
IUUC-Pop-099184 Populus trichocarpa 44.21 1.00e-13 70.90
IUUC-Pca-100673 Procavia capensis 85.17 0.00e+00 1739.00
IUUC-Pva-102724 Pteropus vampyrus 88.71 0.00e+00 3088.00
IUUC-Pte-104174 Pyrenophora teres 23.19 1.00e-48 189.00
IUUC-Pyt-104431 Pyrenophora triticirepentis 22.98 2.00e-47 186.00
IUUC-Rno-105474 Rattus norvegicus 88.65 0.00e+00 2336.00
IUUC-Sha-106993 Sarcophilus harrisii 81.26 0.00e+00 2912.00
IUUC-Sar-113447 Sorex araneus 88.22 0.00e+00 2166.00
IUUC-Ssc-115768 Sus scrofa 90.47 0.00e+00 2960.00
IUUC-Tgu-116949 Taeniopygia guttata 73.34 0.00e+00 2492.00
IUUC-Tru-117782 Takifugu rubripes 56.31 0.00e+00 1923.00
IUUC-Tsy-119177 Tarsius syrichta 84.08 0.00e+00 2263.00
IUUC-Tni-120884 Tetraodon nigroviridis 53.11 0.00e+00 1755.00
IUUC-Tbe-128088 Tupaia belangeri 84.14 0.00e+00 1297.00
IUUC-Ttr-129062 Tursiops truncatus 88.37 0.00e+00 3086.00
IUUC-Vpa-130578 Vicugna pacos 86.87 0.00e+00 3003.00
IUUC-Xtr-132244 Xenopus tropicalis 61.27 0.00e+00 2108.00
Created Date 25-Jun-2017

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