iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053432

UUCD1 version

UUC-LoA-01077

Ensembl Protein ID

ENSLAFP00000001663.3

UniProt Accession

G3SPL4; G3SPL4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000001990.3	ENSLAFT00000001989.3	ENSLAFP00000001663.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-109	365.8	738	1068

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n p l++++++  +++++n++n  ++kge+++++  ++++lw+++ ++vsp++++ +++k++ +f g
   Q: 738  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnCYQNDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYVSPKDFKITIGKINDQFAG 824
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 825  YNQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 911
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 912  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 993
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 994  EnLDLSQYVIGPKNN---LKKYSLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVKS---SAAYILFYT 1068
           ***********9988...69*************************88888*******************...********8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MPAVASDPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES KLDRDEEKAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPSNIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCTG TGGCTTCAGA TCCTAAAGAG CTCTACCTCA GTTCTTCACT AAAAGACCTC 60
AATAAGAAGA CAGAAGTCAA ACCCGAGAAA ATAAGCACTA AGAAGTATGT ATCCTTTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	84.13	0.00e+00	1024.00
IUUC-Apl-003226	Anas platyrhynchos	71.29	0.00e+00	1450.00
IUUC-Aca-004936	Anolis carolinensis	60.60	0.00e+00	1199.00
IUUC-Ago-007959	Ashbya gossypii	36.16	6.00e-55	209.00
IUUC-Acl-008102	Aspergillus clavatus	31.04	2.00e-50	194.00
IUUC-Afl-008604	Aspergillus flavus	30.77	1.00e-49	191.00
IUUC-Afu-009001	Aspergillus fumigatus	31.39	2.00e-49	191.00
IUUC-Ani-009291	Aspergillus nidulans	30.86	3.00e-49	190.00
IUUC-Ang-009844	Aspergillus niger	31.67	9.00e-49	188.00
IUUC-Aor-010098	Aspergillus oryzae	30.77	9.00e-49	188.00
IUUC-Ate-010585	Aspergillus terreus	31.34	1.00e-48	188.00
IUUC-Ame-011029	Astyanax mexicanus	61.32	1.00e-70	259.00
IUUC-Bta-013008	Bos taurus	83.31	0.00e+00	987.00
IUUC-Bra-017228	Brassica rapa	39.40	7.00e-49	188.00
IUUC-Cel-018482	Caenorhabditis elegans	33.53	3.00e-51	196.00
IUUC-Cja-019173	Callithrix jacchus	86.34	0.00e+00	1033.00
IUUC-Cfa-021243	Canis familiaris	83.95	0.00e+00	1014.00
IUUC-Cpo-021522	Cavia porcellus	79.01	0.00e+00	1599.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.64	1.00e-80	293.00
IUUC-Csa-023616	Chlorocebus sabaeus	86.18	0.00e+00	1025.00
IUUC-Cho-024381	Choloepus hoffmanni	84.68	0.00e+00	780.00
IUUC-Cin-025287	Ciona intestinalis	49.87	3.00e-97	350.00
IUUC-Csv-026253	Ciona savignyi	48.16	5.00e-86	312.00
IUUC-Cne-026821	Cryptococcus neoformans	39.89	6.00e-74	273.00
IUUC-Dre-028440	Danio rerio	68.20	0.00e+00	723.00
IUUC-Dno-029039	Dasypus novemcinctus	84.47	0.00e+00	1036.00
IUUC-Dor-031043	Dipodomys ordii	95.69	9.00e-132	464.00
IUUC-Dse-031463	Dothistroma septosporum	28.07	2.00e-41	164.00
IUUC-Dme-032089	Drosophila melanogaster	46.28	2.00e-84	307.00
IUUC-Ete-033040	Echinops telfairi	72.99	0.00e+00	1346.00
IUUC-Eca-033449	Equus caballus	83.33	0.00e+00	1018.00
IUUC-Eeu-034693	Erinaceus europaeus	96.12	2.00e-131	463.00
IUUC-Fca-035794	Felis catus	97.05	0.00e+00	919.00
IUUC-Fal-037322	Ficedula albicollis	75.00	0.00e+00	867.00
IUUC-Gmo-038584	Gadus morhua	66.73	0.00e+00	659.00
IUUC-Gga-041188	Gallus gallus	89.37	0.00e+00	885.00
IUUC-Gac-041850	Gasterosteus aculeatus	72.98	0.00e+00	734.00
IUUC-Ggo-045565	Gorilla gorilla	86.34	0.00e+00	1033.00
IUUC-Hsa-046438	Homo sapiens	86.18	0.00e+00	1033.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	81.82	0.00e+00	1651.00
IUUC-Kpa-049321	Komagataella pastoris	33.51	5.00e-49	189.00
IUUC-Lch-050485	Latimeria chalumnae	84.46	0.00e+00	850.00
IUUC-Loc-052769	Lepisosteus oculatus	76.40	0.00e+00	761.00
IUUC-Mcc-055823	Macaca mulatta	86.18	0.00e+00	1033.00
IUUC-Meu-056099	Macropus eugenii	96.28	9.00e-163	567.00
IUUC-Mla-059089	Melampsora laricipopulina	40.18	2.00e-71	264.00
IUUC-Mga-059739	Meleagris gallopavo	89.16	0.00e+00	882.00
IUUC-Mvi-060559	Microbotryum violaceum	40.84	1.00e-76	281.00
IUUC-Mmr-061158	Microcebus murinus	84.42	0.00e+00	1012.00
IUUC-Mdo-061801	Monodelphis domestica	82.34	0.00e+00	948.00
IUUC-Mmu-063665	Mus musculus	77.80	0.00e+00	1570.00
IUUC-Mpu-066738	Mustela putorius furo	84.60	0.00e+00	1020.00
IUUC-Mlu-067307	Myotis lucifugus	82.17	0.00e+00	1025.00
IUUC-Nfi-068410	Neosartorya fischeri	31.11	8.00e-50	192.00
IUUC-Nle-069314	Nomascus leucogenys	86.50	0.00e+00	1037.00
IUUC-Opr-070378	Ochotona princeps	73.15	2.00e-175	609.00
IUUC-Ont-071545	Oreochromis niloticus	75.50	0.00e+00	759.00
IUUC-Oan-073537	Ornithorhynchus anatinus	78.09	0.00e+00	907.00
IUUC-Ocu-074193	Oryctolagus cuniculus	81.60	0.00e+00	978.00
IUUC-Ola-086622	Oryzias latipes	57.47	0.00e+00	1060.00
IUUC-Oga-088271	Otolemur garnettii	86.18	0.00e+00	1028.00
IUUC-Oar-090431	Ovis aries	83.96	0.00e+00	1001.00
IUUC-Ptr-091339	Pan troglodytes	79.41	0.00e+00	1690.00
IUUC-Pan-091783	Papio anubis	81.18	0.00e+00	757.00
IUUC-Psi-093187	Pelodiscus sinensis	64.86	7.00e-152	531.00
IUUC-Pma-094626	Petromyzon marinus	57.96	7.00e-141	493.00
IUUC-Pfo-096463	Poecilia formosa	74.70	0.00e+00	749.00
IUUC-Pab-097645	Pongo abelii	86.72	0.00e+00	1031.00
IUUC-Pva-103222	Pteropus vampyrus	84.57	0.00e+00	751.00
IUUC-Pgr-103408	Puccinia graminis	35.92	9.00e-54	205.00
IUUC-Ptt-103699	Puccinia triticina	46.15	3.00e-68	253.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.11	3.00e-50	194.00
IUUC-Rno-105510	Rattus norvegicus	78.19	0.00e+00	1603.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.71	6.00e-51	196.00
IUUC-Sha-106879	Sarcophilus harrisii	94.11	0.00e+00	931.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	35.63	5.00e-48	185.00
IUUC-Sar-113019	Sorex araneus	92.84	0.00e+00	872.00
IUUC-Sre-115031	Sporisorium reilianum	37.33	3.00e-68	253.00
IUUC-Ssc-116334	Sus scrofa	81.76	0.00e+00	1667.00
IUUC-Tgu-117062	Taeniopygia guttata	74.14	0.00e+00	868.00
IUUC-Tru-117908	Takifugu rubripes	74.70	0.00e+00	743.00
IUUC-Tsy-118867	Tarsius syrichta	77.40	0.00e+00	901.00
IUUC-Tni-120206	Tetraodon nigroviridis	55.78	0.00e+00	1039.00
IUUC-Tme-127144	Tuber melanosporum	39.72	1.00e-77	285.00
IUUC-Tbe-127877	Tupaia belangeri	82.49	9.00e-84	305.00
IUUC-Ttr-128580	Tursiops truncatus	84.04	0.00e+00	1008.00
IUUC-Uma-129340	Ustilago maydis	35.99	7.00e-71	262.00
IUUC-Vpa-130541	Vicugna pacos	80.77	0.00e+00	974.00
IUUC-Xtr-132161	Xenopus tropicalis	77.55	0.00e+00	782.00
IUUC-Xma-134271	Xiphophorus maculatus	74.70	0.00e+00	747.00
IUUC-Yli-134561	Yarrowia lipolytica	36.19	1.00e-59	225.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence