iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004454

UUCD1 version

UUC-AnC-00992

Ensembl Protein ID

ENSACAP00000015192.3

UniProt Accession

H9GMC8; H9GMC8_ANOCA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015395.3	ENSACAT00000015499.3	ENSACAP00000015192.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.20e-100	336.1	160	512
UBD/ZnF/ZnF_UBP	1.80e-25	88.9	27	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ ++  +l+++++k + +lw++++ a+sp++l+ +++
   Q: 160  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDNGVSLVEEFRKTLCALWQGSQAAFSPESLFYVVW 248
           7******************************888877666654444444445577777******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l++el+   n    ++   ++++  +   +   +  +++++ +F+g l++++ cl c+++s +++
   Q: 249  KIMPNFRGYQQQDAHEFMRYLLDHLHRELQGGFNGVSRSSVLLQENSGLSAGGRCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 337
           *****************************7755555555555555555566789999******************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 338  PFLDLSLDIPSQFRNKRSknqengptcTLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 424
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ f+ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+vl+   ++aY+lf
   Q: 425  KVDTYVEFPLRgLDMKCFLLEPENSRPENCLYDLAAVVVHHGsGVGSGHYTAYAAH-EGRWFHFNDSTVTLTDEETVLR---AKAYILF 509
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 510  YVE 512
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc++v+CGRyv+gHa+kHye++q+ +                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWICLTCSNVHCGRYVNGHAKKHYEDAQVSVpnhkkmekqekvqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MECPHLGASV CVAPAAAAFP PGSPSAWCCS VCRSNKSPWI CLTCSNVHCG RYVNGHAKKH 60
YEDAQVSVPN HKKMEKQEKV QHTVCMDCSS YSTYCYRCDD FVVNDTKFGL VQKVRELLQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGTGCC CGCACTTGGG AGCCAGCGTC TGCGTGGCGC CCGCCGCCGC CGCCTTCCCC 60
CCGGGCTCGC CCTCCGCCTG GTGCTGCAGC GGTGAGCAGA GAAGGGAAGG GCAGGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100554453

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	91.99	0.00e+00	864.00
IUUC-Apl-003358	Anas platyrhynchos	93.57	0.00e+00	849.00
IUUC-Ame-011544	Astyanax mexicanus	76.95	0.00e+00	721.00
IUUC-Bta-012738	Bos taurus	92.01	0.00e+00	847.00
IUUC-Cel-018186	Caenorhabditis elegans	37.08	2.00e-55	209.00
IUUC-Cja-018893	Callithrix jacchus	91.21	0.00e+00	852.00
IUUC-Cfa-020607	Canis familiaris	91.99	0.00e+00	847.00
IUUC-Cpo-021828	Cavia porcellus	89.84	0.00e+00	826.00
IUUC-Csa-023884	Chlorocebus sabaeus	93.53	0.00e+00	716.00
IUUC-Cho-024863	Choloepus hoffmanni	82.23	0.00e+00	729.00
IUUC-Dre-028452	Danio rerio	74.27	0.00e+00	726.00
IUUC-Dno-029531	Dasypus novemcinctus	91.70	0.00e+00	800.00
IUUC-Dor-030913	Dipodomys ordii	82.44	4.00e-163	567.00
IUUC-Ete-032611	Echinops telfairi	86.13	0.00e+00	793.00
IUUC-Eca-033622	Equus caballus	92.74	0.00e+00	806.00
IUUC-Eeu-035268	Erinaceus europaeus	87.73	0.00e+00	735.00
IUUC-Fca-035801	Felis catus	92.32	0.00e+00	836.00
IUUC-Fal-036749	Ficedula albicollis	93.37	0.00e+00	810.00
IUUC-Gmo-039598	Gadus morhua	75.63	0.00e+00	751.00
IUUC-Gga-040883	Gallus gallus	93.78	0.00e+00	815.00
IUUC-Gac-042235	Gasterosteus aculeatus	75.68	0.00e+00	721.00
IUUC-Ggo-044767	Gorilla gorilla	87.16	0.00e+00	770.00
IUUC-Hsa-046581	Homo sapiens	91.60	0.00e+00	879.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	91.41	0.00e+00	843.00
IUUC-Lch-049732	Latimeria chalumnae	88.52	0.00e+00	864.00
IUUC-Loc-052371	Lepisosteus oculatus	86.77	0.00e+00	842.00
IUUC-Laf-054565	Loxodonta africana	91.99	0.00e+00	847.00
IUUC-Mcc-055522	Macaca mulatta	91.80	0.00e+00	879.00
IUUC-Meu-056754	Macropus eugenii	81.20	4.00e-162	564.00
IUUC-Mga-060095	Meleagris gallopavo	92.04	2.00e-176	610.00
IUUC-Mmr-060839	Microcebus murinus	91.60	0.00e+00	843.00
IUUC-Mdo-062339	Monodelphis domestica	94.85	0.00e+00	708.00
IUUC-Mmu-063638	Mus musculus	90.62	0.00e+00	814.00
IUUC-Mpu-066647	Mustela putorius furo	94.15	0.00e+00	706.00
IUUC-Mlu-067921	Myotis lucifugus	91.49	0.00e+00	821.00
IUUC-Nle-069752	Nomascus leucogenys	91.80	0.00e+00	880.00
IUUC-Opr-070636	Ochotona princeps	79.49	0.00e+00	674.00
IUUC-Ont-071638	Oreochromis niloticus	76.65	0.00e+00	686.00
IUUC-Oan-073417	Ornithorhynchus anatinus	87.30	0.00e+00	823.00
IUUC-Ocu-074620	Oryctolagus cuniculus	91.60	0.00e+00	846.00
IUUC-Ola-087281	Oryzias latipes	78.87	3.00e-176	610.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.59	4.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	91.02	0.00e+00	874.00
IUUC-Oar-090132	Ovis aries	91.80	0.00e+00	847.00
IUUC-Ptr-090696	Pan troglodytes	92.55	0.00e+00	842.00
IUUC-Pan-092124	Papio anubis	91.60	0.00e+00	875.00
IUUC-Psi-093801	Pelodiscus sinensis	94.61	0.00e+00	707.00
IUUC-Pma-094472	Petromyzon marinus	71.05	2.00e-93	334.00
IUUC-Pfo-096330	Poecilia formosa	77.28	0.00e+00	743.00
IUUC-Pab-098191	Pongo abelii	91.60	0.00e+00	879.00
IUUC-Pca-100341	Procavia capensis	89.68	0.00e+00	657.00
IUUC-Pva-103177	Pteropus vampyrus	91.02	0.00e+00	834.00
IUUC-Rno-105048	Rattus norvegicus	89.69	0.00e+00	801.00
IUUC-Sha-107429	Sarcophilus harrisii	93.05	0.00e+00	814.00
IUUC-Sar-113024	Sorex araneus	91.54	0.00e+00	753.00
IUUC-Ssc-115749	Sus scrofa	91.17	1.00e-141	495.00
IUUC-Tgu-117277	Taeniopygia guttata	93.15	0.00e+00	842.00
IUUC-Tru-117844	Takifugu rubripes	77.09	0.00e+00	741.00
IUUC-Tsy-119456	Tarsius syrichta	89.81	0.00e+00	797.00
IUUC-Tni-120251	Tetraodon nigroviridis	73.45	0.00e+00	760.00
IUUC-Tbe-127423	Tupaia belangeri	84.96	0.00e+00	764.00
IUUC-Ttr-128401	Tursiops truncatus	86.07	0.00e+00	726.00
IUUC-Vpa-130549	Vicugna pacos	82.14	7.00e-152	529.00
IUUC-Xtr-131892	Xenopus tropicalis	80.58	0.00e+00	743.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence