iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054219

UUCD1 version

UUC-LoA-00903

Ensembl Protein ID

ENSLAFP00000026943.1

UniProt Accession

G3UGI5; G3UGI5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000027540.1	ENSLAFT00000028943.1	ENSLAFP00000026943.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.80e-13	50.5	106	153

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 106  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 153
           57899************************...***************9986 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

RRARSRASCG RGSCTAPRPG ACAFYWGPLS VHGAHERRSE PVGTFLVRDS RQNCFFALSV 60
KMASGPTSIR VHFQAGRFHL DGSRESFDCL FELLEHYVAA PRRLLGAPLR QRRVRPLQEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGGGCGC GGAGCAGAGC GAGCTGCGGC CGTGGCAGCT GCACGGCTCC TCGCCCCGGA 60
GCATGCGCGA GAGCCGCCCC GGAGCCCCCC CGCCGCCCCG CCCGCGGCGC CCAGCGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	96.72	2.00e-62	231.00
IUUC-Apl-003313	Anas platyrhynchos	71.32	1.00e-56	212.00
IUUC-Aca-005109	Anolis carolinensis	69.12	1.00e-51	195.00
IUUC-Ame-011550	Astyanax mexicanus	46.75	2.00e-37	148.00
IUUC-Bta-013411	Bos taurus	87.18	3.00e-72	264.00
IUUC-Cja-019595	Callithrix jacchus	87.18	3.00e-72	264.00
IUUC-Cfa-020563	Canis familiaris	86.54	1.00e-71	261.00
IUUC-Cpo-021374	Cavia porcellus	87.82	7.00e-73	266.00
IUUC-Csa-023333	Chlorocebus sabaeus	86.54	6.00e-72	263.00
IUUC-Dre-028507	Danio rerio	46.81	6.00e-35	140.00
IUUC-Dno-029406	Dasypus novemcinctus	85.90	1.00e-70	259.00
IUUC-Ete-032399	Echinops telfairi	86.54	2.00e-71	261.00
IUUC-Eca-033519	Equus caballus	85.26	5.00e-69	253.00
IUUC-Fal-036726	Ficedula albicollis	71.32	4.00e-57	213.00
IUUC-Gmo-039667	Gadus morhua	50.44	1.00e-24	105.00
IUUC-Gga-040970	Gallus gallus	71.32	1.00e-56	212.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.42	4.00e-28	117.00
IUUC-Ggo-045569	Gorilla gorilla	87.18	2.00e-72	265.00
IUUC-Hsa-046010	Homo sapiens	87.18	4.00e-72	263.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	87.18	6.00e-72	263.00
IUUC-Lch-050219	Latimeria chalumnae	64.39	6.00e-49	186.00
IUUC-Loc-052494	Lepisosteus oculatus	58.96	5.00e-44	170.00
IUUC-Mcc-054830	Macaca mulatta	86.54	6.00e-72	263.00
IUUC-Meu-056565	Macropus eugenii	78.68	9.00e-61	226.00
IUUC-Mga-060153	Meleagris gallopavo	70.07	7.00e-56	209.00
IUUC-Mmr-061365	Microcebus murinus	87.18	4.00e-72	263.00
IUUC-Mdo-062824	Monodelphis domestica	78.68	2.00e-60	224.00
IUUC-Mmu-064120	Mus musculus	85.90	1.00e-71	261.00
IUUC-Mpu-066839	Mustela putorius furo	87.18	3.00e-72	264.00
IUUC-Mlu-067829	Myotis lucifugus	86.54	4.00e-72	263.00
IUUC-Nle-069592	Nomascus leucogenys	83.33	1.00e-68	251.00
IUUC-Ont-072173	Oreochromis niloticus	41.45	2.00e-29	121.00
IUUC-Oan-073586	Ornithorhynchus anatinus	56.79	5.00e-17	80.10
IUUC-Ocu-073996	Oryctolagus cuniculus	87.18	3.00e-72	263.00
IUUC-Oba-075150	Oryza barthii	29.91	1.80e-01	28.90
IUUC-Oni-082023	Oryza nivara	38.24	1.40e+00	28.50
IUUC-Ola-087158	Oryzias latipes	42.04	9.00e-31	126.00
IUUC-Oga-088076	Otolemur garnettii	86.54	5.00e-72	263.00
IUUC-Ptr-091241	Pan troglodytes	87.18	3.00e-72	264.00
IUUC-Pan-091836	Papio anubis	86.54	4.00e-72	263.00
IUUC-Psi-093628	Pelodiscus sinensis	73.53	2.00e-57	214.00
IUUC-Pfo-097501	Poecilia formosa	41.45	1.00e-28	119.00
IUUC-Pab-098170	Pongo abelii	87.18	4.00e-72	263.00
IUUC-Pop-100072	Populus trichocarpa	30.95	2.70e-01	29.30
IUUC-Pva-102796	Pteropus vampyrus	87.18	3.00e-72	263.00
IUUC-Rno-105319	Rattus norvegicus	85.90	1.00e-71	261.00
IUUC-Sha-107201	Sarcophilus harrisii	78.68	4.00e-61	226.00
IUUC-Ssc-116004	Sus scrofa	87.18	7.00e-72	263.00
IUUC-Tgu-116836	Taeniopygia guttata	72.06	8.00e-57	213.00
IUUC-Tru-118090	Takifugu rubripes	40.13	1.00e-27	116.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.38	5.00e-24	103.00
IUUC-Vpa-130235	Vicugna pacos	87.18	4.00e-72	263.00
IUUC-Xtr-132610	Xenopus tropicalis	58.33	5.00e-51	193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence