iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013149

Ensembl Protein ID

ENSBTAP00000015449.5

UniProt Accession

O41515; Q6PZ01; MLP3B_BOVIN

Genbank Protein ID

AAS78585.1; AAI02892.1; AAB72082.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta

Genbank Nucleotide ID

AY570553; BC102891; U80885

Gene Name

MAP1LC3B; MAP1ALC3; MAP1LC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000011632.5	ENSBTAT00000015449.5	ENSBTAP00000015449.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	1.90e-48	163.1	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeek 87
           +r+e+v+ ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++l+kiir+rlql+a++a+fllvn  s+vsvs++++e+ye+ek
   Q: 15   QRVEDVRLIREQHPTKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGhSMVSVSTPICEVYESEK 103
           699*************************99****************************************99***************** PP
   S: 88   dedgflyvayaseetfG 104
           dedgfly++yas+etfG
   Q: 104  DEDGFLYMVYASQETFG 120
           ****************9 PP

Organism

Bos taurus

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Protein Sequence
(Fasta)

MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPICEVYE SEKDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAACTCGCC GCCCCCACCC AGCCTGCAGC GCCATGCCGT CCGAGAAAAC CTTCAAACAG 60
CGCCGAACCT TCGGTGGGTG CCGCGGGCCG GACGCTGTCT GAGGGCCGGC GGGGGCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0012505--C:endomembrane system
GO:0005874--C:microtubule
GO:0031090--C:organelle membrane
GO:0000045--P:autophagosome assembly
GO:0070257--P:positive regulation of mucus secretion

KEGG

bta:408001

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001523	Ailuropoda melanoleuca	97.62	7.00e-68	248.00
IUUC-Apl-004007	Anas platyrhynchos	89.08	1.00e-58	217.00
IUUC-Aca-004678	Anolis carolinensis	90.91	1.00e-61	228.00
IUUC-Cja-019405	Callithrix jacchus	99.20	6.00e-70	255.00
IUUC-Cfa-020120	Canis familiaris	97.62	1.00e-67	247.00
IUUC-Cpo-021922	Cavia porcellus	99.17	3.00e-67	246.00
IUUC-Csa-023961	Chlorocebus sabaeus	99.20	6.00e-70	255.00
IUUC-Cho-024909	Choloepus hoffmanni	88.99	2.00e-52	196.00
IUUC-Dre-028586	Danio rerio	92.62	2.00e-64	236.00
IUUC-Dno-029506	Dasypus novemcinctus	98.40	1.00e-68	251.00
IUUC-Dor-030793	Dipodomys ordii	96.00	1.00e-67	247.00
IUUC-Ete-032996	Echinops telfairi	97.22	5.00e-59	218.00
IUUC-Eca-034195	Equus caballus	98.40	3.00e-69	253.00
IUUC-Fca-035717	Felis catus	95.58	8.00e-59	218.00
IUUC-Fal-037169	Ficedula albicollis	86.29	4.00e-60	222.00
IUUC-Gmo-038732	Gadus morhua	89.17	2.00e-62	230.00
IUUC-Gga-041131	Gallus gallus	94.40	6.00e-67	245.00
IUUC-Gac-041441	Gasterosteus aculeatus	88.00	2.00e-63	233.00
IUUC-Ggo-044417	Gorilla gorilla	99.10	2.00e-61	226.00
IUUC-Hsa-046160	Homo sapiens	99.20	6.00e-70	255.00
IUUC-Itr-048601	Ictidomys tridecemlineatus	96.30	5.00e-57	212.00
IUUC-Lch-050631	Latimeria chalumnae	95.08	3.00e-66	243.00
IUUC-Loc-052865	Lepisosteus oculatus	95.83	1.00e-65	240.00
IUUC-Laf-053756	Loxodonta africana	96.83	2.00e-67	247.00
IUUC-Mcc-054698	Macaca mulatta	99.20	6.00e-70	255.00
IUUC-Meu-056702	Macropus eugenii	85.60	4.00e-58	216.00
IUUC-Mga-059558	Meleagris gallopavo	86.40	1.00e-60	224.00
IUUC-Mdo-062675	Monodelphis domestica	97.60	2.00e-68	249.00
IUUC-Mmu-063150	Mus musculus	94.40	2.00e-67	246.00
IUUC-Mpu-066210	Mustela putorius furo	89.60	3.00e-62	230.00
IUUC-Mlu-067216	Myotis lucifugus	90.40	1.00e-60	224.00
IUUC-Nle-069962	Nomascus leucogenys	99.20	6.00e-70	255.00
IUUC-Opr-070758	Ochotona princeps	94.55	3.00e-58	216.00
IUUC-Ont-072582	Oreochromis niloticus	93.33	6.00e-64	235.00
IUUC-Oan-072816	Ornithorhynchus anatinus	91.06	1.00e-61	227.00
IUUC-Ocu-073918	Oryctolagus cuniculus	87.80	2.00e-58	217.00
IUUC-Oga-088260	Otolemur garnettii	96.80	1.00e-68	251.00
IUUC-Oar-090154	Ovis aries	100.00	6.00e-71	258.00
IUUC-Ptr-091009	Pan troglodytes	99.20	6.00e-70	255.00
IUUC-Pan-091694	Papio anubis	99.20	6.00e-70	255.00
IUUC-Psi-093327	Pelodiscus sinensis	93.75	1.00e-58	217.00
IUUC-Pma-094489	Petromyzon marinus	84.17	2.00e-58	216.00
IUUC-Pfo-096338	Poecilia formosa	90.00	3.00e-61	226.00
IUUC-Pab-098381	Pongo abelii	99.19	1.00e-68	251.00
IUUC-Pca-100621	Procavia capensis	96.80	1.00e-68	250.00
IUUC-Pva-102563	Pteropus vampyrus	98.40	3.00e-69	252.00
IUUC-Rno-106063	Rattus norvegicus	95.20	1.00e-67	248.00
IUUC-Sha-107561	Sarcophilus harrisii	97.32	1.00e-59	221.00
IUUC-Sar-113048	Sorex araneus	96.59	2.00e-46	176.00
IUUC-Ssc-116253	Sus scrofa	100.00	6.00e-71	258.00
IUUC-Tgu-117120	Taeniopygia guttata	93.60	2.00e-66	243.00
IUUC-Tru-118140	Takifugu rubripes	92.50	2.00e-63	233.00
IUUC-Tsy-118793	Tarsius syrichta	98.20	9.00e-61	224.00
IUUC-Tbe-127594	Tupaia belangeri	96.40	2.00e-59	219.00
IUUC-Ttr-128932	Tursiops truncatus	100.00	6.00e-71	258.00
IUUC-Vpa-130747	Vicugna pacos	99.10	7.00e-62	228.00
IUUC-Xtr-132757	Xenopus tropicalis	93.55	8.00e-66	241.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence