iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069261

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADFV01128402

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000079.2	ENSNLET00000000098.1	ENSNLEP00000000089.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.60e-80	270.8	177	490

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 177  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 261
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 262  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 334
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 335  STPFWPlspgsegnvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 421
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgk 305
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++
   Q: 422  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQ 490
           *******************5555555555554445555**************************97765 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS 60
CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKSKRHN LAIDLMYGGI YCFLCQDYIY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGACGCCCT CCACGAACCG GGAGATCGCA GCGCAGGCGG TCCGCAGCAG CTGCAGCTCG 60
GGGGCGGTGC CTGCCCCACA GCCTCCCCTC GGCGATCGCG CAGCCCCATC TTTGTCGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001343	Ailuropoda melanoleuca	92.76	0.00e+00	1014.00
IUUC-Apl-003433	Anas platyrhynchos	89.05	0.00e+00	899.00
IUUC-Aca-005347	Anolis carolinensis	85.00	0.00e+00	952.00
IUUC-Acl-008124	Aspergillus clavatus	29.67	7.00e-53	201.00
IUUC-Afu-008912	Aspergillus fumigatus	30.23	2.00e-50	193.00
IUUC-Ani-009168	Aspergillus nidulans	31.63	1.00e-53	204.00
IUUC-Ame-011253	Astyanax mexicanus	81.74	0.00e+00	785.00
IUUC-Bta-013303	Bos taurus	93.58	0.00e+00	1007.00
IUUC-Cja-019283	Callithrix jacchus	94.10	0.00e+00	831.00
IUUC-Cfa-021239	Canis familiaris	93.84	0.00e+00	921.00
IUUC-Cpo-022354	Cavia porcellus	93.71	0.00e+00	1027.00
IUUC-Csa-023145	Chlorocebus sabaeus	95.62	0.00e+00	1047.00
IUUC-Cho-024938	Choloepus hoffmanni	97.41	5.00e-67	248.00
IUUC-Cin-025109	Ciona intestinalis	57.82	1.00e-122	432.00
IUUC-Csv-026214	Ciona savignyi	53.58	5.00e-162	563.00
IUUC-Dre-027433	Danio rerio	89.32	0.00e+00	874.00
IUUC-Dno-030095	Dasypus novemcinctus	92.96	0.00e+00	914.00
IUUC-Dor-030481	Dipodomys ordii	97.11	7.00e-101	360.00
IUUC-Dme-032074	Drosophila melanogaster	48.30	2.00e-125	442.00
IUUC-Ete-033175	Echinops telfairi	78.91	0.00e+00	736.00
IUUC-Eca-033736	Equus caballus	93.60	0.00e+00	914.00
IUUC-Eeu-034814	Erinaceus europaeus	93.91	4.00e-133	468.00
IUUC-Fca-035861	Felis catus	94.24	0.00e+00	920.00
IUUC-Fal-037645	Ficedula albicollis	89.08	0.00e+00	884.00
IUUC-Gmo-038474	Gadus morhua	87.50	2.00e-155	541.00
IUUC-Gga-040624	Gallus gallus	88.00	0.00e+00	964.00
IUUC-Gac-042197	Gasterosteus aculeatus	82.24	0.00e+00	875.00
IUUC-Ggo-044409	Gorilla gorilla	95.43	0.00e+00	1045.00
IUUC-Hsa-046521	Homo sapiens	95.62	0.00e+00	1047.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	93.97	0.00e+00	1010.00
IUUC-Lch-050537	Latimeria chalumnae	89.96	0.00e+00	969.00
IUUC-Loc-052765	Lepisosteus oculatus	79.89	0.00e+00	856.00
IUUC-Lma-053105	Leptosphaeria maculans	33.20	3.00e-66	245.00
IUUC-Laf-053571	Loxodonta africana	93.60	0.00e+00	916.00
IUUC-Mcc-055166	Macaca mulatta	95.62	0.00e+00	1047.00
IUUC-Mga-059709	Meleagris gallopavo	89.05	0.00e+00	899.00
IUUC-Mvi-060530	Microbotryum violaceum	32.72	2.00e-54	206.00
IUUC-Mmr-060988	Microcebus murinus	94.27	0.00e+00	1033.00
IUUC-Mdo-063065	Monodelphis domestica	90.75	0.00e+00	977.00
IUUC-Mmu-063829	Mus musculus	93.90	0.00e+00	1032.00
IUUC-Mpu-066687	Mustela putorius furo	91.79	0.00e+00	994.00
IUUC-Nfi-068423	Neosartorya fischeri	30.23	4.00e-51	195.00
IUUC-Ncr-068809	Neurospora crassa	28.85	1.00e-52	201.00
IUUC-Opr-070469	Ochotona princeps	75.18	0.00e+00	635.00
IUUC-Ont-071961	Oreochromis niloticus	85.58	0.00e+00	920.00
IUUC-Oan-073565	Ornithorhynchus anatinus	82.46	0.00e+00	867.00
IUUC-Ocu-074435	Oryctolagus cuniculus	99.18	0.00e+00	1021.00
IUUC-Ola-086743	Oryzias latipes	84.08	0.00e+00	705.00
IUUC-Oga-089131	Otolemur garnettii	91.31	0.00e+00	1023.00
IUUC-Oar-089319	Ovis aries	93.80	0.00e+00	915.00
IUUC-Ptr-090783	Pan troglodytes	91.99	0.00e+00	927.00
IUUC-Pan-092927	Papio anubis	95.43	0.00e+00	1045.00
IUUC-Psi-093670	Pelodiscus sinensis	88.19	0.00e+00	899.00
IUUC-Pma-094323	Petromyzon marinus	66.39	0.00e+00	670.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.08	3.00e-55	209.00
IUUC-Pfo-096462	Poecilia formosa	85.85	0.00e+00	937.00
IUUC-Pab-097612	Pongo abelii	95.81	0.00e+00	1048.00
IUUC-Pva-102409	Pteropus vampyrus	76.00	0.00e+00	795.00
IUUC-Pte-104340	Pyrenophora teres	31.81	2.00e-59	223.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.20	2.00e-65	243.00
IUUC-Rno-105247	Rattus norvegicus	94.10	0.00e+00	1035.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.05	3.00e-48	186.00
IUUC-Sar-113174	Sorex araneus	76.67	0.00e+00	793.00
IUUC-Tgu-116938	Taeniopygia guttata	91.90	0.00e+00	908.00
IUUC-Tru-117622	Takifugu rubripes	85.11	0.00e+00	937.00
IUUC-Tsy-119431	Tarsius syrichta	81.84	0.00e+00	766.00
IUUC-Tni-120661	Tetraodon nigroviridis	86.94	0.00e+00	945.00
IUUC-Ttr-129006	Tursiops truncatus	81.14	0.00e+00	840.00
IUUC-Uma-129455	Ustilago maydis	31.74	3.00e-34	140.00
IUUC-Xtr-132444	Xenopus tropicalis	87.38	0.00e+00	958.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence